Myxofibrosarcoma of the thyroid gland

AbstractIntroductionMyxofibrosarcoma of the thyroid is exceptional: a Medline search found a single case report. We report a new case which raised diagnostic and therapeutic problems.ObservationWe report the case of a 74-year-old woman who presented with swelling of the left thyroid lobe and ipsilateral cervical lymphadenopathy. Total thyroidectomy with cervical lymph-node dissection was performed. Histological analysis diagnosed myxofibrosarcoma. Evolution was marked by rapid local recurrence, and chemotherapy based on doxorubicin and ifosfamide was introduced.Discussion/conclusionHead and neck myxofibrosarcoma is rare. MRI is essential and should always precede treatment. Diagnosis is histological. There is elevated risk of local recurrence after resection, accompanied by worsening tumor grade, whence the need for accurate diagnosis, appropriate treatment and regular MRI follow-up

Prototypical Organic–Oxide Interface: Intramolecular Resolution of Sexiphenyl on In₂O₃(111)

The performance of an organic semiconductor device is critically determined by the geometric alignment, orientation, and ordering of the organic molecules. Although an organic multilayer eventually adopts the crystal structure of the organic material, the alignment and configuration at the interface with the substrate/electrode material are essential for charge injection into the organic layer. This work focuses on the prototypical organic semiconductor para-sexiphenyl (6P) adsorbed on In₂O₃(111), the thermodynamically most stable surface of the material that the most common transparent conducting oxide, indium tin oxide, is based on. The onset of nucleation and formation of the first monolayer are followed with atomically resolved scanning tunneling microscopy and noncontact atomic force microscopy (nc-AFM). Annealing to 200 °C provides sufficient thermal energy for the molecules to orient themselves along the high-symmetry directions of the surface, leading to a single adsorption site. The AFM data suggests an essentially planar adsorption geometry. With increasing coverage, the 6P molecules first form a loose network with a poor long-range order. Eventually, the molecules reorient into an ordered monolayer. This first monolayer has a densely packed, well-ordered (2 × 1) structure with one 6P per In₂O₃(111) substrate unit cell, that is, a molecular density of 5.64 × 10¹³ cm^–2

New Family of Cerium Halide Based Materials: CeX₃·ROH Compounds Containing Planes, Chains, and Tetradecanuclear Rings

Six members of a new family of cerium-halide-based materials with promising scintillation behavior have been synthesized in single crystal form, and their crystal structures were determined. Specifically, these new compounds are [(CeCl₃)₇(BuOH)₁₆(H₂O)₂]·(BuOH)₂ (<b>1</b>), (CeBr₃)₁₄(BuOH)₃₆ (<b>2</b>), [(CeCl₃)₇(1-PrOH)₁₆(H₂O)₂]·(1-PrOH)₂ (<b>3</b>), [(CeBr₃)₇(1-PrOH)₁₈]·(1-PrOH)₂ (<b>4</b>), [(CeCl₃)₆(iBuOH)₁₅]·(iBuOH)₂ (<b>5</b>), and CeCl₃(<i>sec-</i>BuOH)₂(H₂O) (<b>6</b>). Additionally, the scintillation ability of compound <b>1</b> was established. The structures of these cerium-halide-based materials consist of catenated tetradecanuclear rings that arrange themselves into three distinct structural motifs which contain the largest lanthanide-based ring structures reported to date; the different motifs are obtained by involving specific alcohols during synthesis. Specifically, <i>n</i>-butanol and <i>n</i>-propanol lead to 1-D chains of tetradecanuclear rings, and <i>iso</i>-butanol leads to 2-D parquet-patterned sheets of rectangular tetradecanuclear rings, while <i>sec</i>-butanol results in a zigzag 1-D chain structure. One of the compounds, [(CeCl₃)₆(iBuOH)₁₅]·(iBuOH)₂, has been shown to scintillate with a light yield of up to 1920 photons/MeV, and due to the presence of protons, it should be capable of detecting high energy neutrons without the necessity of prior thermalization. Furthermore, it also appears to be the first cerium-based compound that scintillates in spite of the fact that water coordinates to two of the Ce­(III) centers within the structure

New Family of Cerium Halide Based Materials: CeX₃·ROH Compounds Containing Planes, Chains, and Tetradecanuclear Rings

Six members of a new family of cerium-halide-based materials with promising scintillation behavior have been synthesized in single crystal form, and their crystal structures were determined. Specifically, these new compounds are [(CeCl₃)₇(BuOH)₁₆(H₂O)₂]·(BuOH)₂ (<b>1</b>), (CeBr₃)₁₄(BuOH)₃₆ (<b>2</b>), [(CeCl₃)₇(1-PrOH)₁₆(H₂O)₂]·(1-PrOH)₂ (<b>3</b>), [(CeBr₃)₇(1-PrOH)₁₈]·(1-PrOH)₂ (<b>4</b>), [(CeCl₃)₆(iBuOH)₁₅]·(iBuOH)₂ (<b>5</b>), and CeCl₃(<i>sec-</i>BuOH)₂(H₂O) (<b>6</b>). Additionally, the scintillation ability of compound <b>1</b> was established. The structures of these cerium-halide-based materials consist of catenated tetradecanuclear rings that arrange themselves into three distinct structural motifs which contain the largest lanthanide-based ring structures reported to date; the different motifs are obtained by involving specific alcohols during synthesis. Specifically, <i>n</i>-butanol and <i>n</i>-propanol lead to 1-D chains of tetradecanuclear rings, and <i>iso</i>-butanol leads to 2-D parquet-patterned sheets of rectangular tetradecanuclear rings, while <i>sec</i>-butanol results in a zigzag 1-D chain structure. One of the compounds, [(CeCl₃)₆(iBuOH)₁₅]·(iBuOH)₂, has been shown to scintillate with a light yield of up to 1920 photons/MeV, and due to the presence of protons, it should be capable of detecting high energy neutrons without the necessity of prior thermalization. Furthermore, it also appears to be the first cerium-based compound that scintillates in spite of the fact that water coordinates to two of the Ce­(III) centers within the structure