Volume 4, Number 6 - March 1924

Volume 4, Number 6 - March 1924. Contains 38 pages including covers and advertisements. Contents Keleher, James F., St. Thomas, Teacher of Teachers O\u27Reilly, J. C., A Vindication of the Fat Man Eldy, Francis, Query Ford, Earle F. and Lynch, James H., Not in the Act Keleher, James F., Lent Barry, T. Henry, The Observer The Hotchpotch Editorials Holohan, Edward V., College Chronicle Mitchell, Joseph V., Alumni Lynch, James H., Exchange Bradley, Howard F., Athletic

Volume 3, Number 4 - January 1923

Volume 3, Number 4 - January 1923. 49 pages including covers and advertisements. Contents Mitchell, J. R., Alma Mater Lynch, James H., Crime and Coueism K., J.F., A Song of the Reformed T., F. J., A Canoe Trip Keleher, James F., The Radical Influence in Modern Poetry Dwyer, Edward, Day by Day Simpson, V. G., The Snow Curran, Robert E., American Liberty Outraged Kielty, Francis, Bedtime Lucubrations Fitzgerald, John F., Oh! Lynch, James H., Wards of the Nation Observing Things Our Debators Editorials Simpson, V.G., Echoes of Christmas Chimes Said the Walrus to the Carpenter Palmer, John, Cycle of Years Mitchell, J. R., College Chronicle Olivier, Lucien, Exchang

Volume 4, Number 8 - May 1924

Volume 4, Number 8 - May 1924. 40 pages including covers and advertisements. Contents Vonnery, Francis, Death Callahan, Albert J., John Francis Walsh Fratus, Frederick J., Arthur Ernest Cannon Halloran, John J., Joseph Bernard Walsh Keleher, James F., Prayer Barry, T. Henry, The Observer The Hotchpotch Editorials Holohan, Edward V., College Chronicle Mitchell, Joseph V., Alumni Lynch, James H., Exchange Bradley, Howard F., Athletic

Volume 4, Number 4 - January 1924

Volume 4, Number 4 - January 1924. 46 pages including covers and advertisements. Contents Mitchell, Joseph V., Fantasy Donnelly, Thomas M., K-C at the Bat Vonnery, Francis, Resignation Lynch, James H., Just Dan\u27l Vonnery, Francis, Lament Barry, T. Henry, The Observer The Hotchpotch Editorials Holohan, Edward V., College Chronicle Mitchell, Joseph V., Alumni Lynch, James H., Exchange Bradley, Howard F., Athletic

A model-based assessment of the cost-utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients.

This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: Lynch syndrome is an autosomal dominant cancer predisposition syndrome caused by mutations in the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2. Individuals with Lynch syndrome have an increased risk of colorectal cancer, endometrial cancer, ovarian and other cancers. Lynch syndrome remains underdiagnosed in the UK. Reflex testing for Lynch syndrome in early-onset colorectal cancer patients is proposed as a method to identify more families affected by Lynch syndrome and offer surveillance to reduce cancer risks, although cost-effectiveness is viewed as a barrier to implementation. The objective of this project was to estimate the cost-utility of strategies to identify Lynch syndrome in individuals with early-onset colorectal cancer in the NHS. METHODS: A decision analytic model was developed which simulated diagnostic and long-term outcomes over a lifetime horizon for colorectal cancer patients with and without Lynch syndrome and for relatives of those patients. Nine diagnostic strategies were modelled which included microsatellite instability (MSI) testing, immunohistochemistry (IHC), BRAF mutation testing (methylation testing in a scenario analysis), diagnostic mutation testing and Amsterdam II criteria. Biennial colonoscopic surveillance was included for individuals diagnosed with Lynch syndrome and accepting surveillance. Prophylactic hysterectomy with bilateral salpingo-oophorectomy (H-BSO) was similarly included for women diagnosed with Lynch syndrome. Costs from NHS and Personal Social Services perspective and quality-adjusted life years (QALYs) were estimated and discounted at 3.5% per annum. RESULTS: All strategies included for the identification of Lynch syndrome were cost-effective versus no testing. The strategy with the greatest net health benefit was MSI followed by BRAF followed by diagnostic genetic testing, costing £5,491 per QALY gained over no testing. The effect of prophylactic H-BSO on health-related quality of life (HRQoL) is uncertain and could outweigh the health benefits of testing, resulting in overall QALY loss. CONCLUSIONS: Reflex testing for Lynch syndrome in early-onset colorectal cancer patients is predicted to be a cost-effective use of limited financial resources in England and Wales. Research is recommended into the cost-effectiveness of reflex testing for Lynch syndrome in other associated cancers and into the impact of prophylactic H-BSO on HRQoL.NIH

Volume 4, Number 9 - June 1924

Volume 4, Number 9 - June 1924. 73 pages including covers and advertisements. Contents Vonnery, Francis, June The Senior Class The Junior Class Lynch, James H., Mud in Your Eye Vonnery, Francis, Broken Moon The Sophomore Pre-Medical Class Barry, T. Henry, The Observer Vonnery, Francis, Light Love Griffin, William V., The Sophomore Class O\u27Neill, William H., The Freshman Class The Hotchpotch Editorials Holohan, Edward V., College Chronicle Mitchell, Joseph V., Alumni Lynch, James H., Exchange Bradley, Howard F., Athletic

Volume 5, Number 1 - October 1924

Volume 5, Number 1 - December 1924. 31 pages including covers and advertisements. Contents Carroll, Thomas P., A Night Prayer Address of John E. Doneley, M.D. Lynch, James H., Indian Summer O\u27Connor, W. Harold, Faltering Love C. Conlon, James, Columbus Curran, Robert E., Ignoring the Franchise Carroll, Thomas P., An Antique Shop Barry, T. Henry, The Observer The Hotchpotch Editorials Fitzpatrick, John J., College Chronicle Ford, Earl F., Alumni Conlon, James C., Exchange Norton, Vernon C., Athletic

Volume 4, Number 1 - October 1923

Volume 4, Number 1 - October 1923. 46 pages and inlcuding covers and advertisements. Contents: Dwyer, Francis L., Girl Overhead Singing Keleher, James F., Reality and Realism Vonnery, Francis, A Parting Farrell, Howard J., The Heart Speaketh Lynch, James H., The Legend of the Spree Barry, T. Henry, The Observer The Hotchpotch Editorials Holohan, Edward V., College Chronicle Mitchell, Joseph V., Alumni K., J. F., October 12, 1923 Lynch, James H., Exchanges Bradley, Howard F., Athletic

Volume 3, Number 6 - March 1923

Volume 3, Number 6 - March 1923. 38 pages including covers and advertisements. Contents Eldy, Francis, The Silver Crown Keliher, J. F., The Indubitable Thomas Gibbon, Charles A., Try It Dwyer, Francis L., Unusual Boppell, Leo J., A Real Short Story K., J. F., Spring of Life Lynch, James H., 135 Bedside Eldy, Francis, Silver Plated Said the Walrus to the Carpenter K., J. F., Filio Dominici Editorial K., J. F., Youth Mitchell, J., College Chronicle Simpson, V. F., Eternal Promise Olivier, L., Exchang

Volume 3, Number 9 - June 1923

Volume 3, Number 9- June 1923. 84 pages including covers and advertisements. Contents Keleher, James F., Prayer for the Class of 1923 Ashworth, Charles J., The Senior Class Curran, Robert E., The Pioneers Connor William J., The Junior Class Lynch, James H., The Wild Man from B Street Curran, Robert E., The Sophomore Class Redmond, Paul J., Said the Walrus to the Carpenter\u27 Grourke, John, Sometimes Barry, T. Henry, Observing Things Brickley, Arthur J., The Freshmen Class Lynch, James H., An Age of Specialists Dwyer, Francis L., Editorials\u27 Nagle, Edward J., A Bit of the Sea in Winter Holohan, Edward, Bdue-itis Mulvin, John, Colonial Days Olivier, Lucien, Exchanges Mitchell, Joseph V., College Chronicle Lynch, James H., Just-a-Thinking McCarthy, Justin Athletics Illustrations The Senior Class The Junior Class The Sophomore Class The Freshman Class The Alembic Staff The Cast of What\u27s What The Baseball Team The Football Squa