Statistical mapping of MTR abnormalities in five CIS patients (A–E) showing various extent of GM injury (range 2–73%).

<p>Statistical mapping of MTR abnormalities in five CIS patients (A–E) showing various extent of GM injury (range 2–73%).</p

Demographic and clinical characteristics of patients.

<p>ON: Optic Nerve, SC: Spinal Cord, B: Brainstem, H: Hemisphere.</p

Sensitivity of individual MTR statistical mapping analysis.

<p>MTR maps of 6 controls were decreased uniformly in MTR by 1 to 15%. Statistical mapping analyses of these modified MTR maps were then assessed and quantified using the predefined threshold showing presence of clusters for all subjects for a 4% decrease in MTR.</p