24,040 research outputs found
Numerical simulation of solid tumor blood perfusion and drug delivery during the âvascular normalization windowâ with antiangiogenic therapy
This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled
Dictionary Learning and Sparse Coding-based Denoising for High-Resolution Task Functional Connectivity MRI Analysis
We propose a novel denoising framework for task functional Magnetic Resonance
Imaging (tfMRI) data to delineate the high-resolution spatial pattern of the
brain functional connectivity via dictionary learning and sparse coding (DLSC).
In order to address the limitations of the unsupervised DLSC-based fMRI
studies, we utilize the prior knowledge of task paradigm in the learning step
to train a data-driven dictionary and to model the sparse representation. We
apply the proposed DLSC-based method to Human Connectome Project (HCP) motor
tfMRI dataset. Studies on the functional connectivity of cerebrocerebellar
circuits in somatomotor networks show that the DLSC-based denoising framework
can significantly improve the prominent connectivity patterns, in comparison to
the temporal non-local means (tNLM)-based denoising method as well as the case
without denoising, which is consistent and neuroscientifically meaningful
within motor area. The promising results show that the proposed method can
provide an important foundation for the high-resolution functional connectivity
analysis, and provide a better approach for fMRI preprocessing.Comment: 8 pages, 3 figures, MLMI201
Phonon arithmetic in a trapped ion system
Single-quantum level operations are important tools to manipulate a quantum state. Annihilation or creation of single particles translates a quantum state to another by adding or subtracting a particle, depending on how many are already in the given state. The operations are probabilistic and the success rate has yet been low in their experimental realization. Here we experimentally demonstrate (near) deterministic addition and subtraction of a bosonic particle, in particular a phonon of ionic motion in a harmonic potential. We realize the operations by coupling phonons to an auxiliary two-level system and applying transitionless adiabatic passage. We show handy repetition of the operations on various initial states and demonstrate by the reconstruction of the density matrices that the operations preserve coherences. We observe the transformation of a classical state to a highly non-classical one and a Gaussian state to a non-Gaussian one by applying a sequence of operations deterministically
Ge quantum dot arrays grown by ultrahigh vacuum molecular beam epitaxy on the Si(001) surface: nucleation, morphology and CMOS compatibility
Issues of morphology, nucleation and growth of Ge cluster arrays deposited by
ultrahigh vacuum molecular beam epitaxy on the Si(001) surface are considered.
Difference in nucleation of quantum dots during Ge deposition at low (<600 deg
C) and high (>600 deg. C) temperatures is studied by high resolution scanning
tunneling microscopy. The atomic models of growth of both species of Ge
huts---pyramids and wedges---are proposed. The growth cycle of Ge QD arrays at
low temperatures is explored. A problem of lowering of the array formation
temperature is discussed with the focus on CMOS compatibility of the entire
process; a special attention is paid upon approaches to reduction of treatment
temperature during the Si(001) surface pre-growth cleaning, which is at once a
key and the highest-temperature phase of the Ge/Si(001) quantum dot dense array
formation process. The temperature of the Si clean surface preparation, the
final high-temperature step of which is, as a rule, carried out directly in the
MBE chamber just before the structure deposition, determines the compatibility
of formation process of Ge-QD-array based devices with the CMOS manufacturing
cycle. Silicon surface hydrogenation at the final stage of its wet chemical
etching during the preliminary cleaning is proposed as a possible way of
efficient reduction of the Si wafer pre-growth annealing temperature.Comment: 30 pages, 11 figure
Highly efficient and reliable high power InGaN/GaN LEDs with 3D patterned step-like ITO and wavy sidewalls
Nitride-based high power LEDs with finger-like SiO2 current blocking layer (CBL), three-dimensional (3D) patterned step-like ITO double layers and wavy sidewalls were fabricated. The finger-like SiO2 CBL beneath finger-like p-electrode was designed to prevent current crowding effect, thereby facilitating uniform current spreading over the entire chip. In addition, 3D patterned step-like ITO double layers, including alternating 230ânm thick patterned upper step ITO layer and 100ânm thick lower step ITO layer, were formed by combining photolithography and aqua regia etchant. We showed that the top light extraction efficiency of high power LEDs can be significantly enhanced by taking 3D patterned step-like ITO. The light output power of high power LEDs with 3D patterned step-like ITO double layers is 13.9% higher than that of LEDs with smooth ITO layer. High-power LEDs with wavy sidewalls was fabricated by an optimized mask design in conjunction with dry etching process based on Cl2/BCl3 to improve light extraction efficiency at the horizontal direction. We demonstrated that light output power of high power LEDs with wavy sidewalls can be improved by 11% as compared to LEDs with flat sidewalls
Infrared stability of ABJ-like theories
We consider marginal deformations of the superconformal ABJM/ABJ models which
preserve N=2 supersymmetry. We determine perturbatively the spectrum of fixed
points and study their infrared stability. We find a closed line of fixed
points which is IR stable. The fixed point corresponding to the ABJM/ABJ models
is stable under marginal deformations which respect the original SU(2)xSU(2)
invariance, while deformations which break this group destabilize the theory
which then flows to a less symmetric fixed point. We discuss the addition of
flavor degrees of freedom. We prove that in general a flavor marginal
superpotential does not destabilize the system in the IR. An exception is
represented by a marginal coupling which mixes matter charged under different
gauge sectors. Finally, we consider the case of relevant deformations which
should drive the system to a strongly coupled IR fixed point recently
investigated in arXiv:0909.2036 [hep-th].Comment: 1+11 pages, 4 figures; v2: minor correction
Exact factorization of the time-dependent electron-nuclear wavefunction
We present an exact decomposition of the complete wavefunction for a system
of nuclei and electrons evolving in a time-dependent external potential. We
derive formally exact equations for the nuclear and electronic wavefunctions
that lead to rigorous definitions of a time-dependent potential energy surface
(TDPES) and a time-dependent geometric phase. For the molecular ion
exposed to a laser field, the TDPES proves to be a useful interpretive tool to
identify different mechanisms of dissociation.Comment: 4 pages, 2 figure
Positive Semidefiniteness and Positive Definiteness of a Linear Parametric Interval Matrix
We consider a symmetric matrix, the entries of which depend linearly on some
parameters. The domains of the parameters are compact real intervals. We
investigate the problem of checking whether for each (or some) setting of the
parameters, the matrix is positive definite (or positive semidefinite). We
state a characterization in the form of equivalent conditions, and also propose
some computationally cheap sufficient\,/\,necessary conditions. Our results
extend the classical results on positive (semi-)definiteness of interval
matrices. They may be useful for checking convexity or non-convexity in global
optimization methods based on branch and bound framework and using interval
techniques
Excitonic ferromagnetism in the hexaborides
A ferromagnet with a small spontaneous moment but with a high Curie
temperature can be obtained by doping an excitonic insulator made from a spin
triplet exciton condensate. Such a condensate can occur in a semimetal with a
small overlap or a semiconductor with a small bandgap. We propose that it is
responsible for the unexpected ferromagnetism in the doped hexaboride material
Ca_{1-x}La_xB_6.Comment: 4 pages, 3 figure
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