Enantioselective Construction of Spirocyclic Oxindole Derivatives with Multiple Stereocenters via an Organocatalytic Michael/Aldol/Hemiacetalization Cascade Reaction

An efficient organocatalytic Michael/aldol/hemiacetalization cascade reaction for construction of enantioenriched spirocyclic oxindoles fused with tetrahydropyrane has been developed. The desired highly functionalized 5′,6′-dihydro-2′<i>H</i>,4′<i>H</i>-spiro­[indoline-3,3′-pyran]-2-one derivatives containing multiple stereogenic centers were obtained in moderate to high chemical yields and with high stereoselectivities

Enantioselective Construction of Spirocyclic Oxindole Derivatives with Multiple Stereocenters via an Organocatalytic Michael/Aldol/Hemiacetalization Cascade Reaction

An efficient organocatalytic Michael/aldol/hemiacetalization cascade reaction for construction of enantioenriched spirocyclic oxindoles fused with tetrahydropyrane has been developed. The desired highly functionalized 5′,6′-dihydro-2′<i>H</i>,4′<i>H</i>-spiro­[indoline-3,3′-pyran]-2-one derivatives containing multiple stereogenic centers were obtained in moderate to high chemical yields and with high stereoselectivities