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Hierarchical Assembly of DNA Nanostructures Based on Four-Way Toehold-Mediated Strand Displacement
Because of its attractive
cost and yield, hierarchical assembly,
in which constituent structures of lower hierarchy share a majority
of components, is an appealing approach to scale up DNA self-assembly.
A few strategies have already been investigated to combine preformed
DNA nanostructures. In this study, we present a new hierarchical assembly
method based on four-way toehold-mediated strand displacement to facilitate
the combination of preformed DNA structural units. Employing such
a method, we have constructed a series of higher-order structures
composed of 5, 7, 9, 11, 13, and 15 preformed units respectively