Characteristics of the cohorts included in this analysis of the genetics of fish consumption.

<p>Characteristics of the cohorts included in this analysis of the genetics of fish consumption.</p

Regional association plot.

<p>The figures display–log10 p-values for SNPs within the locus of highest significance for the analysis of fish consumption (top panel) and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) consumption (bottom panel). The degree of linkage disequilibrium (r²) is displayed in gradients of gray from dark (low linkage) to light (high linkage).</p

Interrogation of best SNPs with the smallest p-value within known EA loci in AA for trait WHR ratio adjusted for BMI.

<p>The index SNPs are from Heid et al, Nature Genetics 2010 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen.1003681-Heid1" target="_blank">[17]</a>. Note that <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t003" target="_blank"><b>Tables 3</b></a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t004" target="_blank"><b>4</b></a> show different information for the same loci (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t003" target="_blank"><b>Table 3</b></a> for index SNP and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t004" target="_blank"><b>Table 4</b></a> for best SNPs with the smallest p-value).</p>1<p>effect allele/other allele.</p>2<p>effect allele frequency.</p>3<p>number of independent (typed) SNPs interrogated in AA sample.</p>4<p>Bonferroni p-value threshold (0.05/N³).</p>5<p>HapMAP LD information.</p>6<p>one-side test p-value.</p>7<p>P_2GC: double GC-corrected p-value.</p

SNPs associated with waist-related trait at p<5.0E-6 in Stage 1.

1<p>effect allele/other allele.</p>2<p>effect allele frequency.</p>3<p>one-side test p-value.</p>4<p>P_2GC: double GC-corrected p-value.</p

Regional association plots for <i>LHX2</i> and <i>RREB1</i> in GIANT consortium with participants of European ancestry.

<p>The blue arrow points to the index SNPs identified from the samples of African ancestry and red arrow points to the best SNPs in GIANT consortium samples of European ancestry.</p

Examination of index SNPs within known loci in EA in AA for trait WHR ratio adjusted for BMI.

<p>The index SNPs is from Heid et al, Nature Genetics 2010 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen.1003681-Heid1" target="_blank">[17]</a>.</p>1<p>effect allele/other allele.</p>2<p>effect allele frequency.</p>3<p>Significance classification refers to the interrogation results of best SNP in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t004" target="_blank"><b>Table 4</b></a>.</p>4<p>p-value of heterogeneity test of beta between EA and AA samples.</p

Cross-trait associations for novel loci from Stage1 + Stage 2 in participants of African ancestry.

1<p>effect allele/other allele.</p>2<p>effect size based on Stage 1 and Stage 2 combined sample.</p

Study sample characteristics.

<p>Study sample characteristics.</p

Regional association plots based on single GC-corrected p-value for <i>LHX2</i> and <i>RREB1</i>, Stage 1 only.

<p>MAF = minor allele frequency. The p-values for the index SNP rs2075064 in <i>LHX2</i> loci are 5.5E-8, 0.03, and 2.2E-8 for Stage 1, Stage 2 and joint analysis. The p-values for the index SNP rs6931262 at <i>RREB1</i> loci are 5.3E-8, 0.02 and 2.5E-8 for Stage 1, Stage 2 and joint analysis. The double GC-corrected p-value for the joint analysis are 6.5E-8, 5.7E-8 and 1.8E-6 for rs2075064, rs6931262 and rs1294410, respectively.</p

Regional association plots for all confirmed loci from the GIANT locus interrogation.

<p>Each figure is centered by the index SNP (big red) with rs-number and p-value information (stage 1 only); another big rectangle is the best SNP in African Americans, with information including MAF = minor allele frequency; linkage disequilibrium information in HapMap YRI and CEU<i>; P_D, P_F, and P_J</i> are the single GC-corrected p-value obtained from discovery cohorts only, follow-up cohorts and joint discovery and follow-up data, respectively. Double GC-corrected p-value can be found in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t004" target="_blank"><b>Table 4</b></a>.</p