Vitamin B12 measurements across neurodegenerative disorders.

Background:Vitamin B12 deficiency causes a number of neurological features including cognitive and psychiatric disturbances, gait instability, neuropathy, and autonomic dysfunction. Clinical recognition of B12 deficiency in neurodegenerative disorders is more challenging because it causes defects that overlap with expected disease progression. We sought to determine whether B12 levels at the time of diagnosis in patients with Parkinson's disease (PD) differed from those in patients with other neurodegenerative disorders. Methods:We performed a cross-sectional analysis of B12 levels obtained around the time of diagnosis in patients with PD, Multiple System Atrophy (MSA), Dementia with Lewy Bodies (DLB), Alzheimer's disease (AD), Progressive Supranuclear Palsy (PSP), Frontotemporal Dementia (FTD), or Mild Cognitive Impairment (MCI). We also evaluated the rate of B12 decline in PD, AD, and MCI. Results:In multivariable analysis adjusted for age, sex, and B12 supplementation, we found that B12 levels were significantly lower at time of diagnosis in patients with PD than in patients with PSP, FTD, and DLB. In PD, AD, and MCI, the rate of B12 decline ranged from - 17 to - 47 pg/ml/year, much greater than that reported for the elderly population. Conclusions:Further studies are needed to determine whether comorbid B12 deficiency affects progression of these disorders

Impact of Climate Variations on Soybean Yield in Eastern Arkansas: 1960-2014

Climate is the major factor affecting crop production; therefore, various agro-meteorological indicators have been frequently used to evaluate the impact of climate on crop production. In this study, we examined the temporal variations of agrometeorological indicators (growing degree days, total precipitation, dry spells and drought indices) during 1960-2014 and their impact on soybean yields in East Arkansas. Results show an increasing trend in growing degree days (GDDs) and dry spells, though the total precipitation during the soybean growing season remained nearly unchanged during the study period. Generally, GDDs and dry spells show a strong correlation with yields. We also evaluated drought variability based on different drought indices, including the Palmer Drought Severity Index (PDSI), the Standardized Precipitation Index (SPI) and the Standardized Precipitation-Evapotranspiration Index (SPEI). The drought indices are all negatively correlated to soybean yields. Overall, the one month SPEI showed the strongest impact on yields. After regression analysis, Dry spells and Total precipitation were the only significant factors in the General Linear Model (GLM)

Radiotracers for SPECT imaging: Current scenario and future prospects

Single photon emission computed tomography (SPECT) has been the cornerstone of nuclear medicine and today it is widely used to detect molecular changes in cardiovascular, neurological and oncological diseases. While SPECT has been available since the 1980s, advances in instrumentation hardware, software and the availability of new radiotracers that are creating a revival in SPECT imaging are reviewed in this paper. The biggest change in the last decade has been the fusion of CT with SPECT, which has improved attenuation correction and image quality. Advances in collimator design, replacement of sodium iodide crystals in the detectors with cadmium zinc telluride (CZT) detectors as well as advances in software and reconstruction algorithms have all helped to retain SPECT as a much needed and used technology. Today, a wide spectrum of radiotracers is available for use in cardiovascular, neurology and oncology applications. The development of several radiotracers for neurological disorders is briefly described in this review, including [ 123I]FP-CIT (DaTSCAN ™) available for Parkinson's disease. In cardiology, while technetium-99m labeled tetrofosmin and technetium-99m labeled sestamibi have been well known for myocardial perfusion imaging, we describe a recently completed multicenter clinical study on the use of [ 123I]mIBG (AdreView ™) for imaging in chronic heart failure patients. For oncology, while bone scanning has been prevalent, newer radiotracers that target cancer mechanisms are being developed. Technetium-99m labeled RGD peptides have been reported in the literature that can be used for imaging angiogenesis, while technetium-99m labeled duramycin has been used to image apoptosis. While PET/CT is considered to be the more advanced technology particularly for oncology applications, SPECT continues to be the modality of choice and the workhorse in many hospitals and nuclear medicine centers. The cost of SPECT instruments also makes them more attractive in developing countries where the cost of a scan is still prohibitive for many patients

Mineral content of red skinned potatoes of Eastern India

Potato tuber colour is an important factor that influences consumer preferences. Eastern plain region of India contributes about 50% of total potato acreage and production. Consumers in this region generally prefer red skinned varieties. Growing awareness for nutrient rich food can create a niche market for nutritious potatoes. Potato is crop of choice for mineral biofortification owing to better mineral bioavailability due to its high ascorbic acid and minimal phytate content. Iron and zinc are the essentially required minerals for good health. Considering the nutritional importance of these elements and wider prevalence of their deficiency in Indian sub-continent, thirteen Eastern regions red skinned advanced hybrids and varieties were evaluated to find the genetic diversity for iron and zinc content. A significant wide range of contents was observed for both the elements. High heritability of both mineral suggests feasibility of selecting genotypes for breeding nutrient rich varieties. Identified genotypes can be utilised as parental lines for future breeding programme and can be released as nutrient rich potato variety

Analysing the Adoption Barriers of Low-Carbon Operations: A Step Forward for Achieving Net-Zero Emissions

In November 2021, the 26th United Nations Climate Change Conference (COP26) was held in Glasgow, UK, the global leaders from nearly 200 countries stressed taking immediate action on the climate issue and how to ensure global net-zero emissions by 2030. It is possible to accelerate the transition to low-carbon energy systems, the present study seeks to identify and analyse key barriers to Low Carbon Operations (LCO) in emerging economies. A critical literature review was undertaken to recognise the barriers linked to the adoption of LCO. To validate these barriers, an empirical study with a dataset of 127 respondents from the Indian automobile industry was conducted. The validated barriers were analysed using Best Worst Method (BWM) and Decision-Making Trial and Evaluation Laboratory (DEMATEL) techniques. BWM is used to determine the priority ranking of barriers, while the DEMATEL method is employed to elucidate the cause-effect inter-relationships among the listed barriers. The results suggest that ‘Economic’ is the most influential category of barriers followed by ‘Infrastructure’ and ‘Operational’. The results also show that the barriers ‘Economic’, ‘Environmental’, ‘Infrastructure’ and ‘Organizational Governance’ belong to the cause group. Some significant managerial implications are recommended to overcome these barriers and to assist firms in the successful adoption of LCO and achieving net-zero emissions. The work was carried out in the automotive industry in India but provides findings that may have wider applicability in other developing countries and beyond

Role of male behavior in cervical carcinogenesis among women with one lifetime sexual partner

Background: The role of male behavior in the genesis of cervical cancer was examined. In India, where the incidence of cervical cancer is among the highest in the world, promiscuity among women is virtually unknown. In this study, the authors investigated the role of male behavior in cervical carcinogenesis among Indian women who had one lifetime sexual partner. Methods: A case-control study was used. Results. Premarital sexual relationships (relative risk [RR], 1.9; confidence interval, 1.2-3.2) and extramarital sexual relationships (RR, 2.7; confidence interval, 1.5-4.9) of husbands were risk factors. When husbands had sexual relationships both before and during the marriage, their wives' risk of getting cervical cancer increased by 6.9 (CI, 2.3-20.7). Risk also increased with husbands having three or more extramarital sexual partners (RR, 3.05; CI, 1.25-12.6). Sexual contact with prostitutes before or after marriage, however, did not increase the risk. History of sexually transmitted disease before marriage (RR, 2.9) or after marriage (RR, 5.9) was an important risk factor, which persisted after controlling for other factors. Sexual abstinence for 40 or more days after a wife's giving birth or having an abortion provided protection. Sex with uncircumcised men or men circumcised after age 1 year increased the risk of cervical cancer (RR, 4.1). Bidi smoking (bidi is a cheap smoking stick of 4-8 cm, consisting of a rolled piece of dried temburni leaf [Diospyres melanoxylon] containing 0.15-0.25 g of coarsely ground tobacco) for more than 20 years was a significant risk factor (RR = 2.4), whereas cigarette smoking was not a risk factor. Conclusions: Male sexual partners play a role in cervical carcinogenesis

Achieving Circularity is a Distant Dream: Entrepreneurial Barriers to Circular Business Models in SMEs of Emerging Economies

Purpose: Circularity has acted as an essential phenomenon for Small and Medium Enterprises (SMEs) in emerging economies, pressuring entrepreneurs to its adoption in their businesses. During the adoption and implementation of circularity, entrepreneurs or circular entrepreneurs (to be precise) are facing various challenges to its effective functioning. However, the scholarly literature has offered limited research into this phenomenon. Thus, the purpose of this research is to identify the various barriers and sub-barriers for circular entrepreneurs to adopt circularity in SMEs of emerging economies. Design/methodology/approach: A combined qualitative and quantitative approach was employed to achieve the objectives of the study. In the first stage, through an extensive literature review, a list of barriers was identified and in the second stage, a deductive approach was employed to finalize the barriers. Finally, Best-Worst Method (BWM), a multi-criteria decision-making (MCDM) method, was used to analyze the significant importance of the barriers. Findings: The findings of the study suggested the ‘financial barrier’ as the first-ranked barrier in the adoption of Circular Business Models (CBMs), followed by the ‘regulatory and operational barriers’ as the top second and third barriers. In terms of sub-barriers, ‘lack of access to funding and capital’ has been identified as the top sub-barrier in the adoption of CBM, followed by ‘excessive regulations and red tape’ and ‘challenges due to ambiguity of the concept’. Practical implications: To transition from a circular to a linear business approach considerably quicker and smoother, entrepreneurs may utilize the findings of this study as a blueprint for the steps to overcome the barriers in a linear to a circular transition. Originality: This research differentiates from other studies due it solicited input directly from the people who are most familiar with the challenges of making the transition from linear to CBM, i.e. the entrepreneurs themselves

Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis

Ebola virus VP35 inhibits alpha/beta interferon production and functions as a viral polymerase cofactor. Previously, the 8-kDa cytoplasmic dynein light chain (LC8) was demonstrated to interact with VP35, but the functional consequences were unclear. Here we demonstrate that the interaction is direct and of high affinity and that binding stabilizes the VP35 N-terminal oligomerization domain and enhances viral RNA synthesis. Mutational analysis demonstrates that VP35 interaction is required for the functional effects of LC8

Cancer Research UK procedures in manufacture and toxicology of radiotracers intended for Pre-phase I positron emission tomography studies in cancer patients

Radiolabelled compounds formulated for injection (radiopharmaceuticals), are increasingly being employed in drug development studies. These can be used in tracer amounts for either pharmacokinetic or pharmacodynamic studies. Such radiotracer studies can also be carried out early in man, even prior to conventional Phase I clinical testing. The aim of this document is to describe procedures for production and safety testing of oncology radiotracers developed for imaging by positron emission tomography in cancer patients. We propose strategies for overcoming the inability to produce compounds in sufficient quantities via the radiosynthetic routes for full chemical characterisation and toxicology testing including (i) independent confirmation as far as possible that the stable compound associated with the radiopharmaceutical is identical to the non-labelled compound, (ii) animal toxicity studies with ⩾10 times (typically 100 times) the intended tracer dose in humans scaled by body surface area, and (iii) patient monitoring during the radiotracer positron emission tomography clinical trial

Total Productive Maintenance and Industry 4.0 in a Sustainability Context: Exploring the Mediating Effect of Circular Economy

The purpose of this research is to establish a conceptual model to understand the impact of Total Productive Maintenance (TPM) and Industry 4.0 (I4.0) on the transition of a Circular Economy (CE). Also, the paper explores the combined impact of TPM, I4.0, and CE on the sustainability performance (SP) of manufacturing firms. The conceptual model is proposed using the dynamic capability view (DCV) and empirically validated by partial least squares-structural equation modelling (PLS-SEM) using 304 responses from Indian manufacturing firms. The results suggest that I4.0 positively impacts TPM, CE, and SP, also showing TPM's positive impact on CE and SP. In addition, CE has a positive influence on the SP of manufacturing firms. Furthermore, CE partially mediates the relationship between I4.0 and SP with TPM and SP. The study also identifies TPM, I4.0, and CE as a new bundle of dynamic capabilities to deliver SP in manufacturing firms. The present research adds to the knowledge and literature on DCV by identifying the importance of CE in the settings of I4.0 and TPM, especially in the context of sustainability. Also, the current study offers a new set of dynamic capabilities and provides some significant future recommendations for researchers and practitioners