Overview of integration of visceral leishmaniasis as an AIDS-defining condition in WHO guidelines.

<p>AIDS: Acquired Immunodeficiency Syndrome; ART: antiretroviral treatment; NTD: neglected tropical diseases; VL: visceral leishmaniasis; WHO: World Health Organization.</p

Cumulative incidence of lipoatrophy.

<p>Kaplan-Meier curve showing the proportion of patients substituting stavudine due to lipoatrophy.</p

Diagnostic performance at different cut-offs of the clinical prediction scores to identify virological failure using an independent dataset.

<p>CPS: clinical prediction score; PPV: positive predictive value; % VL done: percentage of patients that would undergo targeted VL testing; LHR: likelihood ratio.</p

Factors associated with advanced HIV at enrolment in HIV care, Phnom Penh, Cambodia (2003–2013).

<p>CI: confidence interval; OR: adjusted odds ratio (adjusted for all variables in the table); VCT: voluntary counselling and testing</p><p>^aData are shown stratified per period since there were statistically significant interactions between period and age group, and between period and enrolment referral source.</p><p>Associations with a <i>P</i>-value < 0.05 are written in bold</p><p>^bOverall P value for age: (2003–2006); <0.001 (2007–2010); <0.001 (2011–2013)</p><p>^cP value for trend for age: 0.231 (2003–2006); <0.001 (2007–2010); <0.001 (2011–2013)</p><p>^dOverall P value for enrolment referral source: <0.001 (2003–2006); 0.0043 (2007–2010); 0.032 (2011–2013)</p><p>Factors associated with advanced HIV at enrolment in HIV care, Phnom Penh, Cambodia (2003–2013).</p

Evolution in the median CD4 count at enrolment into HIV care, Phnom Penh, Cambodia (2003–2013).

<p>Evolution in the median CD4 count at enrolment into HIV care, Phnom Penh, Cambodia (2003–2013).</p

Risk factors for severe toxicity related to stavudine.

<p>aHR: adjusted hazard ratio, CI: confidence interval, WHO: world health organization, BMI: body mass index, NNRTI: non-nucleoside reverse transcriptase inhibitor; EFV: efavirenz; NVP: nevirapine; TB: tuberculosis; ART: antiretroviral treatment.</p

Baseline characteristics of adult patients initiating stavudine-containing antiretroviral treatment (N = 2581).

<p>IQR: interquartile range, WHO: world health organization, ART: antiretroviral therapy.</p>a<p>From 2006, stavudine was prescribed as 30 mg bid, irrespective of body weight. Prior to that, 40 mg bid was given for individuals with a body weight >60 kg.</p

Content and diagnostic performance of the simplified clinical prediction scores to identify virological failure^a.

<p>ART: antiretroviral treatment; AUROC: area under the receiver-operating characteristic curve; CPS: clinical prediction score; PPE: papular pruritic eruption; VAS: visual analogue scale.</p>a<p>differences between CPSs in the score of some predictors relate to the fact that the weight of each remaining predictor was recalculated after removing of specific predictors (<i>eg</i> after removing hemoglobin in CPS2 vs CPS1).</p>b<p>over a period of six months prior to viral load measurement.</p>c<p>over a period of one month prior to viral load measurement.</p

Evolution in the proportion of individuals enrolling with WHO clinical stage IV, Phnom Penh, Cambodia (2003–2013).

<p>Evolution in the proportion of individuals enrolling with WHO clinical stage IV, Phnom Penh, Cambodia (2003–2013).</p

Characteristics of adults enrolling into HIV care stratified by period, Phnom Penh, Cambodia (2003–2013; N = 5642).

<p>IQR: interquartile range; VCT: voluntary counselling and testing; WHO: World Health Organization</p><p>Characteristics of adults enrolling into HIV care stratified by period, Phnom Penh, Cambodia (2003–2013; N = 5642).</p