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Beyond the ‘sham’ critique and the narrative of humanitarianism: A rejoinder to Jochen von Bernstorff
Abstract
We are very grateful to Professor von Bernstorff for taking the trouble to read and comment on our article,1 which is a segment of a larger research project. His feedback will be invaluable in taking this project successfully to its next stage. While we could not address each and every aspect of his critique, the following response addresses four elements: the assertion that we argued that international humanitarian law (IHL) is merely a sham; his description of our historical approach as focused on the domestic; the ramifications of our historical analysis for future interpretation of IHL; and the challenge of one’s Vorverständnis to historical research.</jats:p
Novel application of query-based qualitative predictors for characterization of solvent accessible residues in conjunction with protein sequence homology. Proceedings of the 22nd International Workshop on Database and Expert Systems Applications
Coarse-graining protein energetics in sequence variables
We show that cluster expansions (CE), previously used to model solid-state
materials with binary or ternary configurational disorder, can be extended to
the protein design problem. We present a generalized CE framework, in which
properties such as energy can be unambiguously expanded in the amino-acid
sequence space. The CE coarse grains over nonsequence degrees of freedom (e.g.,
side-chain conformations) and thereby simplifies the problem of designing
proteins, or predicting the compatibility of a sequence with a given structure,
by many orders of magnitude. The CE is physically transparent, and can be
evaluated through linear regression on the energies of training sequences. We
show, as example, that good prediction accuracy is obtained with up to pairwise
interactions for a coiled-coil backbone, and that triplet interactions are
important in the energetics of a more globular zinc-finger backbone.Comment: 10 pages, 3 figure
Identification of a novel cell type in peripheral lymphoid organs of mice: III. Functional properties in vivo
[No abstract available
Hormonal adaptations to different training intensities during the preparation of elite judokas for competition
Many efforts are made to quantify objectively the balance between training load and the athlete’s tolerance. The aim of the present study was to evaluate the balance between anabolic (i.e. testosterone and IGF-I) and catabolic (i.e. cortisol) hormones in elite judokas during their preparations (4 months) for the European championships. Five healthy elite Israeli judokas (four male, one female, age range 17–26 years) were tested at baseline, after two months of moderate training, after another one month of intense training, after one month of tapering down prior to the competition, and during the week after the championships. Hormonal level remained relatively unchanged during period of moderate training. Circulating levels of IGF-I and testosterone decreased and the cortisol/testosterone ratio increased during intense training. However, only the decrease in circulating IGF-I level reached statistical significance. Both levels of IGF-I and testosterone increased significantly, and the cortisol/testosterone ratio decreased significantly following tapering down, prior to the championships, compared to the levels during intense training. Changes in the balance of anabolic and catabolic hormones during the training season may help elite athletes and assist their coaches in their preparation for the competition
How well-proportioned are lens and prism spaces?
The CMB anisotropies in spherical 3-spaces with a non-trivial topology are
analysed with a focus on lens and prism shaped fundamental cells. The
conjecture is tested that well proportioned spaces lead to a suppression of
large-scale anisotropies according to the observed cosmic microwave background
(CMB). The focus is put on lens spaces L(p,q) which are supposed to be oddly
proportioned. However, there are inhomogeneous lens spaces whose shape of the
Voronoi domain depends on the position of the observer within the manifold.
Such manifolds possess no fixed measure of well-proportioned and allow a
predestined test of the well-proportioned conjecture. Topologies having the
same Voronoi domain are shown to possess distinct CMB statistics which thus
provide a counter-example to the well-proportioned conjecture. The CMB
properties are analysed in terms of cyclic subgroups Z_p, and new point of view
for the superior behaviour of the Poincar\'e dodecahedron is found
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