Costs of the SBI intervention, per person.

<p>Costs of the SBI intervention, per person.</p

Incremental costs and effects of SBI compared to current practice scenario for the target population.

<p>Incremental costs and effects of SBI compared to current practice scenario for the target population.</p

Costs per QALY gained for different fractions of effect maintained in long run.

<p>Costs per QALY gained for different fractions of effect maintained in long run.</p

Impact of the SBI. Estimates and their 95% confidence interval (between brackets).

*<p>Derived from the annual General Public Health and Lifestyle Survey (Dutch initials: POLS) conducted by Statistics Netherlands.</p

Estimates of total incremental costs and effects due to SBI intervention and their 95% confidence interval (between brackets).

a<p>Discounted with 1.5%.</p>b<p>Discounted with 4%.</p>c<p>QALYs and life years gained discounted with 1.5% and costs discounted with 4%.</p>*<p>Only SBI costs included.</p

Summary of assumptions and input data.

a<p>Pooled estimate from all studies selected and described in Bertholet et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005696#pone.0005696-Bertholet1" target="_blank">[10]</a>. A logistic random effects regression analyses with only a constant was carried to obtain the effect estimate and the uncertainty surrounding it.</p>b<p>Pooled estimate from all studies selected and described in the systematic review by Fiellin et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005696#pone.0005696-Fiellin1" target="_blank">[12]</a>. A logistic random effects regression analyses with only a constant was carried to obtain the effect estimate and the uncertainty surrounding it.</p>c<p>Bertholet et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005696#pone.0005696-Bertholet1" target="_blank">[10]</a>.</p

Cost-effectiveness acceptability curve for alcohol SBI scenario.

<p>Cost-effectiveness acceptability curve for alcohol SBI scenario.</p

Additional file 1: of Chronic obstructive pulmonary disease, bronchial asthma and allergic rhinitis in the adult population within the commonwealth of independent states: rationale and design of the CORE study

“Study questionnaires used in the CORE study” contains description of the patient-reported questionnaires used in the CORE study. (DOCX 16 kb