A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections

Teicoplanin is a glycopeptide antibiotic commonly used to treat Gram-positive bacterial infections in the clinic. The aim of this study was to provide a therapeutic reference for the clinical application and dosage regimen adjustment of teicoplanin by identifying factors associated with its plasma trough concentration (Ctrough). A retrospective study was performed on patients with suspected or documented Gram-positive infections who were hospitalized from November 2017 to January 2020 and treated with teicoplanin while undergoing routine therapeutic drug monitoring (TDM). A total of 112 Ctrough trough measurements were obtained from 72 patients were included in this study. SPSS software was used for correlation analysis and receiver operator characteristic curve (ROC) analysis. The Ctrough for teicoplanin showed statistically significant relationships (P<0.05) with PLT, Scr, CLcr, eGFR, BUN and Cys-C. ROC curve analysis revealed that CLcr and eGFR were more sensitive and specific for Ctrough compared to the other factors. These findings should be considered in the clinical application of teicoplanin and for its dosage adjustment

Poly[diaqua­(μ2-oxalato-κ4 O 1,O 2:O 1′,O 2′)(μ2-pyrazine-2-carboxyl­ato-κ4 N 1,O:O,O′)neodymium(III)]

In the title complex, [Nd(C5H3N2O2)(C2O4)(H2O)2]n, the NdIII atom is ten-coordinated by one N atom and three O atoms from two pyrazine-2-carboxyl­ate ligands, four O atoms from two oxalate ligands and two water mol­ecules in a distorted bicapped square-anti­prismatic geometry. The two crystallographically independent oxalate ligands, each lying on an inversion center, act as bridging ligands, linking Nd atoms into an extended zigzag chain. Neighboring chains are linked by the pyrazine-2-carboxyl­ate ligands into a two-dimensional layerlike network in the (10) plane. The layers are further connected by O—H⋯O and O—H⋯N hydrogen bonds, forming a three-dimensional supra­molecular network

Hemi(4,4′-bipyridinium) hexa­fluorido­phosphate bis­(4-amino­benzoic acid) 4,4′-bipyridine monohydrate

In the title compound, 0.5C10H10N2 2+·PF6 −·C10H8N2·2C7H7NO2·H2O, the cation is located on a center of symmetry. The crystal structure is determined by a complex three-dimensional network of inter­molecular O—H⋯O, O—H⋯N, N—H⋯N and N—H⋯F hydrogen bonds. π–π stacking inter­actions between neighboring pyridyl rings are also present; the centroid–centroid distance is 3.643 (5) Å. The hexa­fluoridophosphate anion is disordered over two positions with site-occupancy factors of ca 0.6 and 0.4

Comparison between Limbal and Pars Plana Approaches Using Microincision Vitrectomy for Removal of Congenital Cataracts with Primary Intraocular Lens Implantation

Purpose. To compare the surgical outcomes of limbal versus pars plana vitrectomy using the 23-gauge microincision system for removal of congenital cataracts with primary intraocular lens implantation. Methods. We retrospectively reviewed all eyes that underwent cataract removal through limbal or pars plana incision. Main outcome measures included visual outcomes and complications. Results. We included 40 eyes (26 patients) in the limbal group and 41 eyes (30 patients) in the pars plana group. The mean age was 46 months. There was no significant difference in best-corrected visual acuity between the two groups (P=0.64). Significantly, more eyes had at least one intraoperative complication in the limbal group than in the pars plana group (P=0.03) that were mainly distributed at 1.5–3 years of age (P=0.01). The most common intraoperative complications were iris aspiration, iris prolapse, and iris injury. More eyes in the limbal group had postoperative complications and required additional intraocular surgery, but the difference was not significant (P=0.19). Conclusions. The visual results were encouraging in both approaches. We recommend the pars plana approach for lower incidence of complications. The limbal approach should be reserved for children older than 3 years of age and caution should be exercised to minimize iris disturbance

Poly[[aqua­(μ2-oxalato)(μ2-2-oxido­pyridinium-3-carboxylato)holmium(III)] monohydrate]

In the title complex, {[Ho(C2O4)(C6H4NO3)(H2O)]·(H2O)}n, the HoIII ion is coordinated by three O atoms from two 2-oxidopyridinium-3-carboxylate ligands, four O atoms from two oxalate ligands and one water mol­ecule in a distorted bicapped trigonal-prismatic geometry. The 2-oxidopyridin­ium-3-carboxylate and oxalate ligands link the HoIII ions into a layer in (100). These layers are further connected by inter­molecular O—H⋯O hydrogen bonds involving the coordinated water mol­ecules to assemble a three-dimensional supra­molecular network. The uncoordin­ated water mol­ecule is involved in N—H⋯O and O—H⋯O hydrogen bonds within the layer

Poly[bis­(4,4′-bipyridine)(μ3-4,4′-dicarboxybiphenyl-3,3′-di­carboxyl­ato)iron(II)]

In the polymeric title complex, [Fe(C16H8O8)(C10H8N2)2]n, the iron(II) cation is coordinated by four O atoms from three different 4,4′-dicarboxybiphenyl-3,3′-di­carboxyl­ate ligands and two N atoms from two 4,4′-bipyridine ligands in a distorted octa­hedral geometry. The 4,4′-dicarboxybiphenyl-3,3′-di­carboxyl­ate ligands bridge adjacent cations, forming chains parallel to the c axis. The chains are further connected by inter­molecular O—H⋯N hydrogen bonds, forming two-dimensional supra­molecular layers parallel to (010)

Poly[(6-carboxy­picolinato-κ3 O 2,N,O 6)(μ3-pyridine-2,6-dicarboxyl­ato-κ5 O 2,N,O 6:O 2′:O 6′)dysprosium(III)]

In the title complex, [Dy(C7H3NO4)(C7H4NO4)]n, one of the ligands is fully deprotonated while the second has lost only one H atom. Each DyIII ion is coordinated by six O atoms and two N atoms from two pyridine-2,6-dicarboxyl­ate and two 6-carboxy­picolinate ligands, displaying a bicapped trigonal-prismatic geometry. The average Dy—O bond distance is 2.40 Å, some 0.1Å longer than the corresponding Ho—O distance in the isotypic holmium complex. Adjacent DyIII ions are linked by the pyridine-2,6-dicarboxyl­ate ligands, forming a layer in (100). These layers are further connected by π–π stacking inter­actions between neighboring pyridyl rings [centroid–centroid distance = 3.827 (3) Å] and C—H⋯O hydrogen-bonding inter­actions, assembling a three-dimensional supra­molecular network. Within each layer, there are other π–π stacking inter­actions between neighboring pyridyl rings [centroid–centroid distance = 3.501 (2) Å] and O—H⋯O and C—H⋯O hydrogen-bonding inter­actions, which further stabilize the structure