19 research outputs found
Risk factors and early outcomes of acute renal injury after thoracic aortic endograft repair for type B aortic dissection
Coronary artery disease as an independent predictor of short-term and long-term outcomes in patients with type-B aortic dissection undergoing thoracic endovascular repair
Background and aimsPrevious studies reported a high prevalence of concomitant coronary artery disease (CAD) in patients with Type B aortic dissection (TBAD). However, there is too limited data on the impact of CAD on prognosis in patients with TBAD. The present study aimed to assess the short-term and long-term impact of CAD on patients with acute or subacute TBAD undergoing thoracic endovascular aortic repair (TEVAR).MethodsWe retrospectively evaluated 463 patients with acute or subacute TBAD undergoing TEVAR from a prospectively maintained database from 2010 to 2017. CAD was defined before TEVAR by coronary angiography. Multivariable logistic and cox regression analyses were performed to evaluate the relationship between CAD and the short-term as well as long-term outcomes.ResultsAccording to the results of coronary angiography, the 463 patients were divided into the following two groups: CAD group (N = 148), non-CAD group (N = 315). In total, 12 (2.6%) in-hospital deaths and 54 (12%) all-cause deaths following a median follow-up of 48.1 months were recorded. Multivariable analysis revealed that CAD was an independent predictor of in-hospital major adverse clinical events (MACE) (odd ratio [OR], 2.33; 95% confidence interval [CI], 1.07â5.08; p = 0.033), long-term mortality [hazard ratio (HR), 2.11, 95% CI, 1.19â3.74, P = 0.011] and long-term MACE (HR, 1.95, 95% CI, 1.26â3.02, P = 0.003). To further clarify the relationship between the severity of CAD and long-term outcomes, we categorized patients into three groups: zero-vessel disease, single-vessel disease and multi-vessel disease. The long-term mortality (9.7 vs. 14.4 vs. 21.2%, P = 0.045), and long-term MACE (16.8 vs. 22.2 vs. 40.4%, P = 0.001) increased with the number of identified stenosed coronary vessels. Multivariable analysis indicated that, multi-vessel disease was independently associated with long-term mortality (HR, 2.38, 95% CI, 1.16â4.89, P = 0.018) and long-term MACE (HR, 2.79, 95% CI, 1.65â4.73, P = 0.001), compared with zero-vessel disease.ConclusionsCAD was associated with short-term and long-term worse outcomes in patients with acute or subacute TBAD undergoing TEVAR. Furthermore, the severity of CAD was also associated with worse long-term prognosis. Therefore, CAD could be considered as a useful independent predictor for pre-TEVAR risk stratification in patients with TBAD
Integrating oculomics with genomics reveals imaging biomarkers for preventive and personalized prediction of arterial aneurysms
Application of rapid artificial cardiac pacing in thoracic endovascular aortic repair in aged patients
Post-implantation Syndrome After Thoracic Endovascular Aortic Repair for Type B Aortic Dissection:Â AÂ Single-center Experience with 646 Cases
Association between triglyceride glucoseâbody mass index and hypertension in Chinese adults: A crossâsectional study
Abstract The triglyceride glucoseâbody mass index (TyGâBMI) has been considered an alternative marker of insulin resistance (IR). This crossâsectional study was designed to mainly investigate the association between TyGâBMI, triglyceride glucose combined with body mass index, and hypertension in Chinese adults. The relationship between TyGâBMI and hypertension was examined by multivariate logistic regression and restricted cubic spline model. Multiple logistic regression models were also performed to examine the associations between the individual components of TyGâBMI (BMI, TyG index, TG and FBG) and hypertension. The incremental ability of TyGâBMI versus its individual components for hypertension discrimination was evaluated by Câstatistic and net reclassification index. Subgroup analysis was performed to examine potential interactions. A total of 92,545 participants (38.9% men, mean age 53.7 years) were included for final analysis. Logistic regression models showed TyGâBMI and its individual components were all significantly associated with the odds of hypertension (p for trend < .001). The restricted cubic spline regression manifested a linear association between TyGâBMI and hypertension (p for nonâlinear = .062). The addition of TyGâBMI, in comparison with each individual component, exhibited the maximum incremental value for the discrimination of hypertension on the basis of base model (Câstatistic: 0.679, 95% CI: 0.675â0.683 for base model vs. 0.695, 95% CI: 0.691â0.699 for base model + TyGâBMI; net reclassification index: 0.226, 95% CI: 0.215â0.234). TyGâBMI was significantly associated with the odds of hypertension and can be a better discriminator of hypertension
Advancing Construction 3D Printing with Predictive Interlayer Bonding Strength: A Stacking Model Paradigm
To enhance the quality stability of 3D printing concrete, this study introduces a novel machine learning (ML) model based on a stacking strategy for the first time. The model aims to predict the interlayer bonding strength (IBS) of 3D printing concrete. The base models incorporate SVR, KNN, and GPR, and subsequently, these models are stacked to create a robust stacking model. Results from 10-fold cross-validation and statistical performance evaluations reveal that, compared to the base models, the stacking model exhibits superior performance in predicting the IBS of 3D printing concrete, with the R2 value increasing from 0.91 to 0.96. This underscores the efficacy of the developed stacking model in significantly improving prediction accuracy, thereby facilitating the advancement of scaled-up production in 3D printing concrete
Molecular Dynamics Simulation Study on Two-Component Solubility Parameters of Carbon Nanotubes and Precisely Tailoring the Thermodynamic Compatibility between Carbon Nanotubes and Polymers
Feasibility and safety of Stanford A aortic dissection complete endovascular repair system in a porcine model
Abstract Background Acute type A aortic dissection (ATAAD) is a catastrophic disease with high morbidity and mortality. Although open surgery is still the gold standard for the treatment of ATAAD, some patients, with advanced age and multiple comorbidities, can only receive medical management alone. Nowadays, thoracic aortic endovascular repair (TEVAR) provides a potential treatment option for the patient with ATAAD, but traditional stent grafts (SGs), which are not designed for the ATAAD, are inapplicable to the unique anatomy of the aortic arch. Therefore, we innovatively created the BRIDGE system (Chuangxin Medical, Shenzhen, China), a complete endovascular reconstruction system designed to treat ATAAD. This study aimed to evaluate the feasibility and safety of the novel Stanford A aortic dissection complete endovascular reconstruction system in a porcine model. Method The BRIDGE system consists of the type A stent system and the type C stent system. Between November 2020 and March 2021, three white swine were utilized in the study. The BRIDGE system was deployed via the transcatheter approach under angiographic guidance. The swine(nâ=â3) treated with our system were evaluated using angiography before sacrifice 1-month after implantation, which was followed by gross specimen evaluation and histological examination of harvested tissues. Result The acute procedure success rate was 100% (3/3). The immediate post-procedural angiography showed that both type A SGs and type C SGs were deployed in satisfactory locations, with patency of the supra-aortic trunk and no endoleak. The cumulative mortality of 30-day was 0% without any adverse events. No device migration or leakage was observed angiographically, before sacrifice. The gross observation confirmed a type A SG covered part of the entry of anonyma. Favorable endothelialization, no thrombogenesis, and slight inflammatory infiltration of the tissues around the device were confirmed by microscopic examinations in all pigs. Conclusion It was feasible and secure to use Stanford A aortic dissection complete endovascular reconstruction system to implement a transcatheter endovascular repair in a porcine model. With this novel system, treating acute type A aortic dissection may be more efficient and secure in human