Volume 5. Article 5. Stomatopoda of the Bingham Oceanographic Collection.

https://elischolar.library.yale.edu/bulletin_yale_bingham_oceanographic_collection/1115/thumbnail.jp

James River Sediment Study: Operation Agnes Final Report

Bottom sediment samples were collected from the James River in Virginia and analyzed to evaluate the effects of tropical storm Agnes (summer, 1972) upon the sediment chemistry . The results of these analyses, frcm hereon called post Agnes data, were compared with data from a similar study carried out during the summer of 1971 ( pre-Agnes data ), reported under contract no. DACW-65-71-C-00~7 . The post Agnes samples encompass three distinct shoaling areas involving a total of 34. 75 nautical miles of the James River . The first area extending from mile 24. 75 to 33. 50 can be considered os the · Oligohaline James River estuary; the second and third areas extending from nautical mile 36.50 to 4o .75 and 57.00 to 59 . 50 respectively are considered part of the lower tidal fresh water James

Comparison of Ionospheric delays between VLBI and GNSS

editorial reviewedVLBI is a differential technique observing at multiple frequencies. Thus, it can independently provide ionospheric delays. GNSS can supply precise ionospheric delays as well, often with comparable or even better spatial coverage. In this presentation, we compare the VLBI differential ionosphere from two sites with multiple VLBI antennas with the co-located GNSS ionospheric calibrations. In S/X VLBI, a linear combination of X-band and S-band delays is used to provide a calibrated group delay measurement that is free of ionospheric effects to first order. In contrast, the VGOS system is designed to provide group delay and ionospheric delay through a simultaneous fit to measurements in 4 frequency bands distributed over a wide frequency range. The CONT17 VGOS data have been calibrated in terms of ionosphere in advance and thus directly provide TEC for each observation. In this work, we compare the extracted ionospheric delays from dual frequency observations of GNSS with the ones from dual frequency S/X VLBI and from co-located VGOS stations in the CONT17 experiment to better understand how well VLBI can contribute to the study of the ionosphere. Since both source structure and ionosphere effects on geodetic VLBI data analysis are dispersive, in the future we will introduce an optimal match for VLBI and GNSS and compare ionospheric delays obtained from different radio sources to help to improve the modeled structure effect

Radio source position offsets among various radio frames and Gaia

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Structure effects in broadband VGOS data

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Comparison between time series of closure analysis and source positions since 1980

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Evaluation of VLBI Observations with Sensitivity and Robustness Analyses

Very Long Baseline Interferometry (VLBI) plays an indispensable role in the realization of global terrestrial and celestial reference frames and in the determination of the full set of the Earth Orientation Parameters (EOP). The main goal of this research is to assess the quality of the VLBI observations based on the sensitivity and robustness criteria. Sensitivity is defined as the minimum displacement value that can be detected in coordinate unknowns. Robustness describes the deformation strength induced by the maximum undetectable errors with the internal reliability analysis. The location of a VLBI station and the total weights of the observations at the station are most important for the sensitivity analysis. Furthermore, the total observation number of a radio source and the quality of the observations are important for the sensitivity levels of the radio sources. According to the robustness analysis of station coordinates, the worst robustness values are caused by atmospheric delay effects with high temporal and spatial variability. During CONT14, it is determined that FORTLEZA, WESTFORD, and TSUKUB32 have robustness values changing between 0.8 and 1.3 mm, which are significantly worse in comparison to the other stations. The radio sources 0506-612, NRAO150, and 3C345 have worse sensitivity levels compared to other radio sources. It can be concluded that the sensitivity and robustness analysis are reliable measures to obtain high accuracy VLBI solutions

P53 Codon 72 (Arg72Pro) Polymorphism and Prostate Cancer Risk: Association between Disease Onset and Proline Genotype

The tumor suppressor gene p53 plays an important role in the stress response of the cell and is mutated in 50% of all human tumors. The p53 Arg72Pro single-nucleotide polymorphism (SNP) was found to be associated with an increased risk of various malignancies. Biochemical and biological differences between the 2 polymorphic variants of wild-type P53 might lead to distinct susceptibility to HPV- and non-HPV-induced tumors. For prostate cancer, only limited data are available, especially in the Caucasian pop-ulation. Therefore, we determined the distribution of the Arg72Pro SNP in a Caucasian case-control study including 118 prostate cancer patients and 194 male controls without any malignancy using restriction fragment length polymorphism analysis. A subset of 33 tumors was tested for HPV infection, and no HPV DNA was found. Cases and controls showed similar distributions of alleles in the SNP (p = 0.720). Regarding the onset of the disease, patients diagnosed at ≤60 years of age and older patients (>60 years of age) showed a significant difference in genotype distribution (p = 0.035); there was also an increased occurrence of risk allele Pro72 in cases aged ≤60 years (p = 0.045). A subset of 64 prostate tumors was stained immunohistochemically for P53. 5 of 64 prostate tumors (7.8%) were positive for P53 expression, indicating integrity of the protein in the majority of cases. Genotype distribution showed no association with the Gleason score or additional histopathological characteristics. This study shows that the overall risk of prostate cancer was not associated with Arg72Pro SNP and HPV infection in our cohort. However, disease onset might be modulated by the p53 Pro72 allele, suggesting an important role of apoptosis regulation in prostate carcinogenesis

Treatment of Refractory Cardiac Arrest by Controlled Reperfusion of the Whole Body:A Multicenter, Prospective Observational Study

Background: Survival following cardiac arrest (CA) remains poor after conventional cardiopulmonary resuscitation (CCPR) (6–26%), and the outcomes after extracorporeal cardiopulmonary resuscitation (ECPR) are often inconsistent. Poor survival is a consequence of CA, low-flow states during CCPR, multi-organ injury, insufficient monitoring, and delayed treatment of the causative condition. We developed a new strategy to address these issues. Methods: This all-comers, multicenter, prospective observational study (69 patients with in- and out-of-hospital CA (IHCA and OHCA) after prolonged refractory CCPR) focused on extracorporeal cardiopulmonary support, comprehensive monitoring, multi-organ repair, and the potential for out-of-hospital cannulation and treatment. Result: The overall survival rate at hospital discharge was 42.0%, and a favorable neurological outcome (CPC 1+2) at 90 days was achieved for 79.3% of survivors (CPC 1+2 survival 33%). IHCA survival was very favorable (51.7%), as was CPC 1+2 survival at 90 days (41%). Survival of OHCA patients was 35% and CPC 1+2 survival at 90 days was 28%. The subgroup of OHCA patients with pre-hospital cannulation showed a superior survival rate of 57.1%. Conclusions: This new strategy focusing on repairing damage to multiple organs appears to improve outcomes after CA, and these findings should provide a sound basis for further research in this area.</p

Treatment of Refractory Cardiac Arrest by Controlled Reperfusion of the Whole Body:A Multicenter, Prospective Observational Study

Background: Survival following cardiac arrest (CA) remains poor after conventional cardiopulmonary resuscitation (CCPR) (6–26%), and the outcomes after extracorporeal cardiopulmonary resuscitation (ECPR) are often inconsistent. Poor survival is a consequence of CA, low-flow states during CCPR, multi-organ injury, insufficient monitoring, and delayed treatment of the causative condition. We developed a new strategy to address these issues. Methods: This all-comers, multicenter, prospective observational study (69 patients with in- and out-of-hospital CA (IHCA and OHCA) after prolonged refractory CCPR) focused on extracorporeal cardiopulmonary support, comprehensive monitoring, multi-organ repair, and the potential for out-of-hospital cannulation and treatment. Result: The overall survival rate at hospital discharge was 42.0%, and a favorable neurological outcome (CPC 1+2) at 90 days was achieved for 79.3% of survivors (CPC 1+2 survival 33%). IHCA survival was very favorable (51.7%), as was CPC 1+2 survival at 90 days (41%). Survival of OHCA patients was 35% and CPC 1+2 survival at 90 days was 28%. The subgroup of OHCA patients with pre-hospital cannulation showed a superior survival rate of 57.1%. Conclusions: This new strategy focusing on repairing damage to multiple organs appears to improve outcomes after CA, and these findings should provide a sound basis for further research in this area.</p