2 research outputs found
Multicomponent Synthesis of Polyphenols and Their In Vitro Evaluation as Potential \u3b2-Amyloid Aggregation Inhibitors
While plant polyphenols possess a variety of biological properties, exploration of chemical
diversity around them is still problematic. Here, an example of application of the Ugi multicomponent
reaction to the combinatorial assembly of artificial, yet \u201cnatural-like\u201d, polyphenols is presented. The
synthesized compounds represent a second-generation library directed to the inhibition of \u3b2-amyloid
protein aggregation. Chiral enantiopure compounds, and polyphenol-\u3b2-lactam hybrids have been
prepared too. The biochemical assays have highlighted the importance of the key pharmacophores in
these compounds. A lead for inhibition of aggregation of truncated protein A\u3b2pE3-42 was selected