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Additional file 3. FTIR spectra and photo of Chit-DC-FITC. (A) FTIR spectra of Chit-DC and Chit-DC-FITC. (B) Fluorescence spectra and a photo of FITC-labeled amphiphilic chitosan derivatives

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Additional file 4. Effects of chronic treatment of Scu or Scu-loaded nanoparticles on body weight and blood-glucose in STZ-induced diabetic rats. (A) The changes of body weight of rats. (B) The changes of blood-glucose in rats. STZ was administrated to the DM group, DM +Chit-DC group, DM + Scu group, DM + Chit-DC-Scu group, and DM + Chit-DC-VB12-Scu group at week 8(n = 8)

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Additional file 2. Synthesis of FITC-labelled amphiphilic chitosan derivatives: (A) the Chit-DC-FITC derivative and (B) the Chit-DC-B12-FITC derivative

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Additional file 1. 1H NMR spectra of (a) deoxycholic acid (DMSO-d6), (b) Chit-DC (D2O), (c) Chit-DC-VB12 (D2O) and (d) vitamin B12 (D2O)