Representative 3D images and mammograms from two different patients.

<p>Left column: sample number 6 (fibrosis, sclerosing adenosis, normal ductal hyperplasia, intraductal papilloma), only spherical MC classified as no suspicious MC; right column: sample number 25 (DCIS high grade), fine linear MC. CC indicates craniocranialcaudal view and MLO indicates mediolateral oblique view.</p

Representative 3D images from different biopsies.

<p>Benign (group A: A–C) lesions, unclear biological potential lesions (group B: D–F) and malignant (group C: G–I) lesions: A (sample number 1, fine pleomorphic), B (sample number 6, no suspicious MC), C (sample number 7, no suspicious MC), D (sample number 15, coarse heterogeneous), E (sample number 16, fine pleomorphic), F (sample number 20, fine linear), G (sample number 22, fine linear), H (sample number 25, fine linear) and I (sample number 24, fine pleomorphic). For more details concerning the different samples, compare sample numbers in Tables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0169349#pone.0169349.t001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0169349#pone.0169349.t002" target="_blank">2</a>.</p

Overview of different morphological parameters including mean number, volume (μm³) and SMI of MC for all different groups (benign: including B-classification B1 and B2; unclear malignant potential: including B-classification B3 and B4; malignant lesions: including B-classification B5).

<p>Error bars indicate the standard error of the mean (SEM).</p

Morphological parameters including object volume (μm³x10⁵) and the structure model index (±SD) of every specimen.

<p>Morphology: fl: fine linear, fp: fine pleomorphic, ch: coarse heterogeneous, ns: no suspicious MC, 1 indicating presence and 0 indicating absence of the respective type of microcalcification.</p