Plasma and urine metabolites significantly associated with the serum osteocalcin concentration.

<p>Plasma and urine metabolites significantly associated with the serum osteocalcin concentration.</p

General characteristics of the study population.

<p>General characteristics of the study population.</p

Corrected p-values (false discovery rate; FDR) from linear regression analyses with osteocalcin concentration as exposure and plasma (left upper panel) or urine (right lower panel) metabolites as outcomes.

<p>Models were adjusted for age, sex, waist circumference and physical activity. The upper right panel contains results for metabolites present in both fluids. Within each panel the dotted lines denote the significance threshold of FDR<0.05. Metabolites are colored if they are significantly associated in plasma (blue), urine (orange) or in both (red), respectively. Metabolites marked with a diamond exceed the plotting range. Metabolites highlighted by increased point size and darker colors persisted significant even after further adjustment for hormone intake, estimated glomerular filtration rate and smoking behavior. Corresponding beta estimates and FDR-values can be found in supplemental Tables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0184721#pone.0184721.t001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0184721#pone.0184721.t002" target="_blank">2</a>. Metabolites numbered with 1 to 7 are named in the lower left panel. Triangles indicate the direction of the association in plasma or urine, with ▲ indicating positive associations.</p