Insulin secretion in the grafted diabetic rats.

<p>Data represent the mean ± SEM of 7 to 8 rats per experimental group. The inset represents the area under the insulinemic curve during the entire ivGTT timecourse (*p<0.05 by Student's t-test). The insulin levels in the STZ rats were not detectable by this method.</p

The composition of the normal- and low-protein diets.

<p>*The mixtures of salts and vitamins that were used in the manufacturing of the diet followed the recommendations of the AIN 93 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030685#pone.0030685-deOliveira1" target="_blank">[13]</a>. Values are presented as g/100 g of diet.</p

The effect of maternal protein restriction on adult rats.

<p>Data represent the mean ± SEM obtained from 30–45 animals per experimental group. Significant differences were determined using Student's t-test with *p<0.001.</p

The effect of the islet grafts on the fasting and non-fasting glycemia of diabetic rats.

<p>The graph shows the effect of grafted islets on fed and fasting plasma glucose levels. Data represent the mean ± SEM of 7 to 8 rats per group. The following letters represent significant differences between all fed groups and all fasting groups by one-way ANOVA where p<0.05 is indicated by (a) control, (b) diabetic (STZ), (c) T NP and (d) T LP.</p

The effects of maternal protein restriction on the glucose and insulin homeostasis of adult rats.

<p>Data represent the mean ± SEM of a minimum of 7 rats per experimental group. <b>A</b>) glucose concentrations for the entire ivGTT timecourse. Inset shows the glycemia AUC for the ivGTT. <b>B</b>) insulin concentrations for the entire ivGTT timecourse. Inset shows the insulinemia AUC for the ivGTT timecourse (*p<0.05, **p<0.01 by Student's t-test).</p

The effect of the islet grafts on the non-fasting glycemia of diabetic rats.

<p>The graph shows the islet grafts' effects on the fed blood glucose concentrations during the 3 days after the islets' transplantation. Data represent the mean ± SEM of 7 to 8 rats per experimental group. The following letters represent significant differences between the groups on the indicated days: (a) control, (b) diabetic (STZ), (c) T NP and (d) T LP (p<0.05 by one-way ANOVA).</p

Glucose-induced insulin secretion from isolated pancreatic islets.

<p>The graph shows the effect of maternal protein restriction on insulin secretion from islets that were stimulated by glucose. The bars represent the mean ± SEM of 6 NP and 7 LP rats (*p<0.05 by Student's t-test).</p

The effect of the islet grafts on the retroperitoneal fat accumulation of diabetic rats.

<p>The graph shows the effect of grafted islets on the retroperitoneal fat pad. Data represent the mean ± SEM of 7 to 8 rats per group. The following letters represent significant differences between all experimental groups by a one-way ANOVA with p<0.05 indicated by (a) control, (b) diabetic (STZ), (c) T NP and (d) T LP.</p