Theory of weakly nonlinear self sustained detonations

We propose a theory of weakly nonlinear multi-dimensional self sustained detonations based on asymptotic analysis of the reactive compressible Navier-Stokes equations. We show that these equations can be reduced to a model consisting of a forced, unsteady, small disturbance, transonic equation and a rate equation for the heat release. In one spatial dimension, the model simplifies to a forced Burgers equation. Through analysis, numerical calculations and comparison with the reactive Euler equations, the model is demonstrated to capture such essential dynamical characteristics of detonations as the steady-state structure, the linear stability spectrum, the period-doubling sequence of bifurcations and chaos in one-dimensional detonations and cellular structures in multi- dimensional detonations

Comment on ``Casimir force in compact non-commutative extra dimensions and radius stabilization''

We call attention to a series of mistakes in a paper by S. Nam [JHEP 10 (2000) 044, hep-th/0008083].Comment: 6 pages, LaTeX, uses JHEP.cl

Immune Checkpoint Blockade and Immune Monitoring

The concept of immunological surveillance, a monitoring process in which the immune system detects and destroys by several effector mechanisms, virally infected and neoplastic transformed cells in the body, was developed more than 50 years ago. Based on current research, it is clear that the immune system can recognize and eliminate transformed cells. An increasing number of studies has investigated the immune system in cancer patients and how it is prone to immunosuppression, due in part to the decrease of lymphocyte proliferation and cytotoxic activity. Such weakened immune system is then unable to fully accomplish its role in immunological surveillance, allowing nascent transformed cells to escape the selective pressure of the immune system. The main goal of cancer immunotherapy has been to reawaken the immune system from a suppressive slumber to enable it to attack cancer cells once again. As the results from the last 10 years attest, cancer immunotherapy is the best strategy to restore the activity of the immune system and unleash its potential to destroy cancer cells in cancer patients. This chapter aims to discuss the recent findings on immune monitoring studies and the use of immune checkpoint inhibition in cancer immunotherapy

Non universality of entanglement convertibility

Recently, it has been suggested that operational properties connected to quantum computation can be alternative indicators of quantum phase transitions. In this work we systematically study these operational properties in 1D systems that present phase transitions of different orders. For this purpose, we evaluate the local convertibility between bipartite ground states. Our results suggest that the operational properties, related to non-analyticities of the entanglement spectrum, are good detectors of explicit symmetries of the model, but not necessarily of phase transitions. We also show that thermodynamically equivalent phases, such as Luttinger liquids, may display different convertibility properties depending on the underlying microscopic model.Comment: 5 pages + references, 4 figures - improved versio

Noncommutative geometry for three-dimensional topological insulators

We generalize the noncommutative relations obeyed by the guiding centers in the two-dimensional quantum Hall effect to those obeyed by the projected position operators in three-dimensional (3D) topological band insulators. The noncommutativity in 3D space is tied to the integral over the 3D Brillouin zone of a Chern-Simons invariant in momentum-space. We provide an example of a model on the cubic lattice for which the chiral symmetry guarantees a macroscopic number of zero-energy modes that form a perfectly flat band. This lattice model realizes a chiral 3D noncommutative geometry. Finally, we find conditions on the density-density structure factors that lead to a gapped 3D fractional chiral topological insulator within Feynman's single-mode approximation.Comment: 41 pages, 3 figure

Theory of weakly nonlinear self-sustained detonations

We propose a theory of weakly nonlinear multidimensional self-sustained detonations based on asymptotic analysis of the reactive compressible Navier-Stokes equations. We show that these equations can be reduced to a model consisting of a forced unsteady small-disturbance transonic equation and a rate equation for the heat release. In one spatial dimension, the model simplifies to a forced Burgers equation. Through analysis, numerical calculations and comparison with the reactive Euler equations, the model is demonstrated to capture such essential dynamical characteristics of detonations as the steady-state structure, the linear stability spectrum, the period-doubling sequence of bifurcations and chaos in one-dimensional detonations and cellular structures in multidimensional detonations