Development of a panoramic third generation IRST: initial study and experimental work

The paper introduces the analysis carried out by Selex ES (SE) for the development of a third generation IRST system based on large format MWIR sensors, separable in blue and red bands. In the feasibility study, physical constraints have been evaluated relying on different optics and scanning options. The goal is a system based on distributed heads to cover 360 with a resolution better than 0.3 mrad and high frame rate that allow to take advantage of the typical atmospheric phenomena of the maritime environment as scintillation and super and sub refraction. Two critical aspects were investigated: (i) the setting of an adequate scanning mechanism to assure a high frame rate and (ii) the stitching of the collected images while maintaining the bit-depth so as to avoid abrupt changes of SNR at the seams between two subsequent images

A comparative analysis of dynamic range compression techniques in IR images for maritime applications

Modern thermal cameras acquire IR images with a high dynamic range because they have to sense with high thermal resolution the great temperature changes of monitored scenarios in specific surveillance applications. Initially developed for visible light images and recently extended for display of IR images, high dynamic range compression (HDRC) techniques aim at furnishing plain images to human operators for a first intuitive comprehension of the sensed scenario without altering the features of IR images. In this context, the maritime scenario represents a challenging case to test and develop HDRC strategies since images collected for surveillance at sea are typically characterized by high thermal gradients among the background scene and classes of objects at different temperatures. In the development of a new IRST system, Selex ES assembled a demonstrator equipped with modern thermal cameras and planned a measurement campaign on a maritime scenario so as to collect IR sequences in different operating conditions. This has led to build up a case record of situations suitable to test HDRC techniques. In this work, a survey of HDRC approaches is introduced pointing out advantages and drawbacks with focus on strategies specifically designed to display IR images. A detailed analysis of the performance is discussed in order to address the task of visualization with reference to typical issues of IR maritime images, such as robustness to the horizon effect and displaying of very warm objects and flat areas

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy compared to the ADH-1 peptide, a N-cadherin antagonist that is in early clinical trials in EOC patients