24 research outputs found
Combinatorial formulas for Kazhdan-Lusztig polynomials with respect to W-graph ideals
In \cite{y1} Yin generalized the definition of -graph ideal in
weighted Coxeter groups and introduced the weighted Kazhdan-Lusztig polynomials
, where is a subset of simple
generators . In this paper, we study the combinatorial formulas for those
polynomials, which extend the results of Deodhar \cite{v3} and Tagawa
\cite{h1}.Comment: 16 page
Systematic Review and Meta-Analysis of Artemisinin Based Therapies for the Treatment and Prevention of Schistosomiasis
<div><h3>Background</h3><p>Chemotherapy based on repeated doses of praziquantel is still the most effective control strategy against Schistosomiasis, however artemisinin derivatives emerged as a family of compounds with schistomicide activity. The aim of the present work is to compare the efficacy of artemisinin-based therapies in the treatment and prophylaxis of human schistosomiasis. The design of this work involved a quantitative systematic review and meta-analysis.</p> <h3>Methodology/Principal Findings</h3><p>Retrieval of published studies was carried out through an electronic search of the PubMed (MEDLINE), EMBASE, Cochrane Library and CINAHL databases. This included reports comparing the therapeutic efficacy of artesunate alone, artesunate <em>plus</em> sulfadoxine-pyrimethamine and a combination of artemisinin derivatives <em>plus</em> praziquantel against praziquantel alone on different types of schistosomiasis. Moreover, studies on artesunate and artemether used as preventive drugs were also analyzed against placebo. The primary outcome measure for schistosomiasis treatment was âparasitological cureâ, whereas for the prophylaxis the outcome evaluated was âinfection rateâ. Our results show that patients treated with artesunate alone have significantly lower cure rates than those treated with praziquantel (ORâ=â0.27 (95% C.I. 0.13â0.53; p<0.001)) and that the combined therapy of artesunate <em>plus</em> sulfadoxine-pyrimethamine is also significantly less effective than praziquantel treatment (ORâ=â0.14 (95% C.I. 0.02â0.92; pâ=â0.04)). However, the combination of an artemisinin derivatives <em>plus</em> praziquantel showed a higher cure rate than praziquantel monotherapy with ORâ=â2.07 (95% C.I. 1.27â3.36; pâ=â0.003). Finally, chemoprophylaxis with either artesunate (RRâ=â0.11 (95% C.I. 0.06â0.22; p<0.001)) or artemether (RRâ=â0.25 (95% C.I. 0.16â0.40; p<0.001)) was significantly better than a placebo in both cases.</p> <h3>Conclusions/Significance</h3><p>This meta-analysis confirms that artemisinin derivatives used in combination with praziquantel have the potential to increase the cure rates in schistosomiasis treatment, but not artesunate alone. It is also confirmed that repeated doses of artemisinin derivatives play a prophylactic role, significantly reducing the incidence of <em>Schistosoma japonicum</em> infections compared with placebo.</p> </div
Forest plot of the random-effects subgroup meta-analysis comparing parasitological cure by artesunate <i>plus</i> sulfadoxine/pyrimethamine <i>vs.</i> praziquantel.
<p>Points represent odds ratios with their corresponding 95% C.I. Intermediate diamonds are combined odds ratios for each subgroup and the diamond at the bottom is the overall combined odds ratio. The vertical line emphasizes an odds ratioâ=â1 (no difference) and the dashed vertical line shows the value of the overall combined odds ratio. The original reports are labeled with author name, year and location (for details see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045867#pone-0045867-t003" target="_blank">table 3</a>).</p
Forest plot of fixed-effect subgroup meta-analysis comparing parasitological cure after treatment with an artemisinin derivative <i>plus</i> praziquantel <i>vs.</i> praziquantel.
<p>Points represent odds ratios with their corresponding 95% C.I. Intermediate diamonds are combined odds ratios for each subgroup and the diamond at the bottom is the overall combined odds ratio. The vertical line emphasizes an odds ratioâ=â1 (no difference) and the dashed vertical line shows the value of the overall combined odds ratio. The original reports are labeled with author name, year and location (for details see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045867#pone-0045867-t002" target="_blank">table 2</a>).</p
Artemether prophylaxis <i>vs.</i> placebo in schistosomiasis due to <i>S. haematobium</i>, <i>S. mansoni</i> and <i>S. japonicum</i>.
1<p>ART: artemether (6 mg/kg); n.d: data not described.</p
Artemisinin derivatives + praziquantel <i>vs.</i> praziquantel in the treatment of schistosomiasis.
1<p>PZQ (praziquantel 40 mg/kg once);</p>2<p>ART (artesunate 4 mg/kg/day, given once per day over 3 days);</p>3<p>ART (artesunate 4 mg/kg) daily for three consecutive days;</p>4<p>ART (artesunate 200mg) on the first day and (100 mg) daily for a further 4 days;</p>5<p>PZQ (praziquantel 1 day, 3Ă20 mg/kg);</p>6<p>ART (artemether 6 mg/kg once);<sup> 7</sup>PZQ (praziquantel 6 days, 3Ă20 mg/kg). n.d: data not described.</p
Meta-analysis comparing artesunate <i>vs</i>. placebo for chemoprophylaxis against schistosomiasis japonica.
<p>The mid-points of the lines represent the relative risk and the end-points of the lines show the corresponding 95% C.I. The diamond at the bottom is the overall relative risk. The vertical line emphasizes an relative riskâ=â1 (no difference) and the dashed vertical line shows the value of the overall relative risk. Relative risk <1 indicates a protective effect of artesunate. The original reports are labeled with author name, year, and location, number of dosis and interval of administration (for details see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045867#pone-0045867-t004" target="_blank">table 4</a>).</p
Forest plot of a random-effects subgroup meta-analysis comparing parasitological cure by artesunate as monotherapy <i>vs.</i> praziquantel.
<p>Points represent odds ratios with their corresponding 95% C.I. Intermediate diamonds are combined odds ratios for each subgroup and the diamond at the bottom is the overall combined odds ratio. The vertical line emphasizes an odds ratioâ=â1 (no difference) and the dashed vertical line shows the value of the overall combined odds ratio. The original reports are labeled with author name, year and location (for details see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045867#pone-0045867-t001" target="_blank">table 1</a>).</p
Flow diagram showing the selection process of studies included in the meta-analysis.
<p>Flow diagram showing the selection process of studies included in the meta-analysis.</p
Subgroup meta-analysis comparing Artemether <i>vs</i>. placebo for chemoprophylaxis against schistosomiasis.
<p>The mid-points of the lines represent the relative risk and the end-points of the lines show the corresponding 95% C.I. Intermediate diamond symbols are combined relative risks for each subgroup and the diamond at the bottom is the overall combined relative risk. The vertical line emphasizes an relative riskâ=â1 (no difference) and the dashed vertical line shows the value of the overall relative risk. Relative risk <1 indicates a protective effect of artemether. The original reports are labeled as follows: author name, year, and location, number of dosis and interval of administration, for details see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045867#pone-0045867-t005" target="_blank">table 5</a>.</p