"Ontological Representation of Constraints for Geographical Reasoning"

We describe a framework that supports multiple types of constraint-based reasoning tasks on a geographic domain, by exploiting a semantic representation of the domain itself and of its constraints. Our approach is based on an abstract graph representation of a geographical area and of its relevant properties, for performing the reasoning tasks. As a test-bed, we consider the domain of Ecological Networks (ENs), which describe the structure of existing real ecosystems and help planning their expansion, conservation and improvement by introducing constraints on land use. While some previous work has been done about supporting the verification of compliance of fully specified ENs, we aim at taking a significant step further, by addressing the automatic suggestion of suitable aggregations of land patches into elements of the EN. This automated generation of EN elements is relevant to support the human planner in the design of public policies for land use because it leverages automated tools to carry out a possibly lengthy and error-prone task

[1,2,3]triazolo[4,5-<i>H</i>]chinoloni: una nuova classe di promettenti chemioterapici antitubercolari

Alcuni acidi triazolo[4,5-h] e [4,5-f]chinoloncarbossilici angolari, sintetizzati in precedenza come antiinfettivi del tratto urinario, hanno mostrato interessanti valori di MIC90 nei confronti di M. tuberculosis H37Rv. Allo scopo di approfondire le nostre conoscenze sui rapporti struttura-attività di questa classe, abbiamo pertanto preparato una nuove serie di derivati

Periprosthetic knee infection: treatment options

Infection is one of the most catastrophic complication following total knee arthroplasty (TKA) and represents the second most common cause of TKA failure. Treatment of a patient with periprosthetic joint infection (PJI) could require often costly and prolonged hospital stays, weeks or months of antibiotic therapy, and multiple surgical procedures. The best management is still highly debating, whereas many treatment options are available. These include suppressive antibiotics, arthroscopic irrigation and debridement, open debridement with insert exchange, single-stage reimplantation and two-stage reimplantation. The choice of the treatment depends on many variables, including integrity of implant, timing of the infection, host factors (age, health, immunologic status), virulence of the infecting organism and wishes of the patient. The aim of this review is to provide a comprehensive understaning of the different options for knee PJIs