Patient characteristics.

<p>LDH = Lactate Dehydrogenase, UNL = Upper Normal Limit, ECOG PS = Eastern Cooperative Oncology Group Performance Status</p><p>Patient characteristics.</p

Multivariable analysis with all factors included in the model.

<p>LDH = lactate dehydrogenase, CT+B = chemotherapy +bevacizumab, CT = chemotherapy, PFS = progression-free survival, HR = Hazard Ratios</p><p>*not adjusted, OS = overall survival, UNL = upper normal limit</p><p>Multivariable analysis with all factors included in the model.</p

LDH and response rate.

<p>LDH = Lactate Dehydrogenase, UNL = Upper Normal Limit, CR = Complete Response, PR = Partial Response, SD = Stable Disease, PD = Progressive Disease</p><p>LDH and response rate.</p

Patient characteristics.

<p>LDH = Lactate Dehydrogenase, UNL = Upper Normal Limit, ECOG PS = Eastern Cooperative Oncology Group Performance Status</p><p>Patient characteristics.</p

PFS and OS according to LDH.

<p>PFS and OS according to LDH.</p

PFS and OS according to treatment as a function of LDH.

<p>PFS and OS according to treatment as a function of LDH.</p

Progression-free survival and overall survival as a function of LDH in CT+B and CT only arms.

<p>LDH = Lactate Dehydrogenase, CT+B = Chemotherapy +Bevacizumab, CT = Chemotherapy, PFS = Progression-Free Survival, HR = Hazard Ratios</p><p>* = not adjusted, OS = Overall Survival, UNL = Upper Normal Limit Interaction test PFS: p = 0.066; Interaction test OS: p = 0.114</p><p>Progression-free survival and overall survival as a function of LDH in CT+B and CT only arms.</p

Consort flowchart.

<p>Consort flowchart.</p

PFS and OS according to LDH in CT+B and CT only arms.

<p>PFS and OS according to LDH in CT+B and CT only arms.</p

Local-regional treatments.

<p>AST: adjuvant systemic therapy</p><p>Local-regional treatments.</p