Student representation and the relationship between student leaders and political Parties: The case of Makerere University

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Transport properties of quantum dots with hard walls

Quantum dots are fabricated in a Ga[Al]As-heterostructure by local oxidation with an atomic force microscope. This technique, in combination with top gate voltages, allows us to generate steep walls at the confining edges and small lateral depletion lengths. The confinement is characterized by low-temperature magnetotransport measurements, from which the dots' energy spectrum is reconstructed. We find that in small dots, the addition spectrum can qualitatively be described within a Fock-Darwin model. For a quantitative analysis, however, a hard-wall confinement has to be considered. In large dots, the energy level spectrum deviates even qualitatively from a Fock-Darwin model. The maximum wall steepness achieved is of the order of 0.4 meV/nm.Comment: 9 pages, 5 figure

Transport properties of quantum dots with hard walls

Quantum dots are fabricated in a Ga[Al]As-heterostructure by local oxidation with an atomic force microscope. This technique, in combination with top gate voltages, allows us to generate steep walls at the confining edges and small lateral depletion lengths. The confinement is characterized by low-temperature magnetotransport measurements, from which the dots' energy spectrum is reconstructed. We find that in small dots, the addition spectrum can qualitatively be described within a Fock-Darwin model. For a quantitative analysis, however, a hard-wall confinement has to be considered. In large dots, the energy level spectrum deviates even qualitatively from a Fock-Darwin model. The maximum wall steepness achieved is of the order of 0.4 meV/nm.Comment: 9 pages, 5 figure

In-plane gate single-electron transistor in Ga[Al]As fabricated by scanning probe lithography

A single-electron transistor has been realized in a Ga[Al]As heterostructure by oxidizing lines in the GaAs cap layer with an atomic force microscope. The oxide lines define the boundaries of the quantum dot, the in-plane gate electrodes, and the contacts of the dot to source and drain. Both the number of electrons in the dot as well as its coupling to the leads can be tuned with an additional, homogeneous top gate electrode. Pronounced Coulomb blockade oscillations are observed as a function of voltages applied to different gates. We find that, for positive top-gate voltages, the lithographic pattern is transferred with high accuracy to the electron gas. Furthermore, the dot shape does not change significantly when in-plane voltages are tuned.Comment: 4 pages, 3 figure

The dance of the positives and negatives of life: Student wellbeing in the context of #FeesMustFall-related violence

Violence has become a regular occurrence in the context of the South African student movement. However, to date there are no studies that investigate student wellbeing in the context of student movement violence. How are violence and wellbeing experienced in the context of the student movement? What resources do students draw upon to protect or restore their wellbeing during and in the aftermath of violence? This article discusses students’ experiences of violence and wellbeing and particularly the resources that fostered their psychological wellbeing during and after experiences of violence related to the #FeesMustFall protests of 2015/16. The study used a photovoice methodology and worked with groups of former student activists from four universities in South Africa. Student psychological functioning in the midst of adverse circumstances is demonstrated in their ability to make meaning of their experiences by inventing knowledge spaces; creating spaces of inner harmony; having a sense of purpose; and protecting symbolic spaces of hope. It is also shown in their courage to challenge spaces of oppression. This study suggests that the co-production of social space for functioning occurs through an important psychological process of meaning-making that provides direction for student movement activities. Given our findings, it is recommended for student affairs and counselling services to  m,./=-09864 facilitate the co-creation of spaces of knowledge and spaces of safety, spaces where students can experience being wanted and connected, and spaces where they can make sense of their experiences in the unfamiliar and potentially alienating higher education space. &nbsp

Precision Upsilon Spectroscopy from Nonrelativistic Lattice QCD

The spectrum of the Upsilon system is investigated using the Nonrelativistic Lattice QCD approach to heavy quarks and ignoring light quark vacuum polarization. We find good agreement with experiment for the Upsilon(1S), Upsilon(2S), Upsilon(3S) and for the center of mass and fine structure of the chi_b states. The lattice calculations predict b-bbar D-states with center of mass at (10.20 +/- 0.07 +/- 0.03)GeV. Fitting procedures aimed at extracting both ground and excited state energies are developed. We calculate a nonperturbative dispersion mass for the Upsilon(1S) and compare with tadpole-improved lattice perturbation theory.Comment: 8 pages, latex, SCRI-94-57, OHSTPY-HEP-T-94-00

537Microparticles and exosomes differentially impact on endothelial cell function in coronary artery disease

Background and Purpose: Microparticles (MPs) and exosomes are released by cells using different mechanisms. Thus, quantitative as well as qualitative changes of both particle populations, MPs and exosomes, in patients with coronary artery disease (CAD) might reflect an altered activation status of the endothelium, platelets and leukocytes. Moreover, they might exert differential effects on the target organs, such as the endothelium. Yet, alterations in both populations have not been studied side-by-side so far. The aim of the study was to compare the impact of MPs and exosomes from healthy subjects and CAD patients on endothelial cell (EC) functional characteristics. Methods: MPs and exosomes were isolated by stepwise filtration and ultracentrifugation from citrate-plasma and verified by electron microscopy and dynamic light scattering. MP and exosome fractions, as well as the vehicle (PBS), were added to human arterial ECs and EC apoptosis, number, size, capacity for in vitro-reendothelialisation after scratching, expression of adhesion molecules ICAM-1 and VCAM-1 were assessed. In parallel, platelet-, endothelial- and leukocyte-derived MPs were quantified. In a separate sub-study, the same parameters were assessed in plasma of CAD patients undergoing standard medical rehabilitation or an exercise-based cardiac rehabilitation programme. Results: MPs of healthy, but not of CAD patients supported in vitro re-endothelialisation, while exosomes had no influence. Exercise, but not standard rehabilitation improved CAD MP capacity to support in vitro rehabilitation. This was negatively correlated to the number of leukocyte- and endothelial-derived MPs, but not total or platelet MPs. EC number was negatively affected by exposure to CAD MPs. ANCOVA analysis identified disease, but not the particle type as influencing factor. Instead, apoptotic cell death was influenced by particle type, but not by the disease, and was not altered in rehabilitation. Similarly, ICAM-1 and VCAM-1 expression were enhanced on ECs after incubation with exosomes, but not with MPs, with no effect of disease or rehabilitation. Conclusion: MPs and exosomes differentially affect endothelial cell function and underlie differential modulation in disease and rehabilitation. Those findings might in the future help to optimize and monitor cardiovascular therap

Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.

Tumor antigen-specific CD4(+) T cells generally orchestrate and regulate immune cells to provide immune surveillance against malignancy. However, activation of antigen-specific CD4(+) T cells is restricted at local tumor sites where antigen-presenting cells (APCs) are frequently dysfunctional, which can cause rapid exhaustion of anti-tumor immune responses. Herein, we characterize anti-tumor effects of a unique human CD4(+) helper T-cell subset that directly recognizes the cytoplasmic tumor antigen, NY-ESO-1, presented by MHC class II on cancer cells. Upon direct recognition of cancer cells, tumor-recognizing CD4(+) T cells (TR-CD4) potently induced IFN-γ-dependent growth arrest in cancer cells. In addition, direct recognition of cancer cells triggers TR-CD4 to provide help to NY-ESO-1-specific CD8(+) T cells by enhancing cytotoxic activity, and improving viability and proliferation in the absence of APCs. Notably, the TR-CD4 either alone or in collaboration with CD8(+) T cells significantly inhibited tumor growth in vivo in a xenograft model. Finally, retroviral gene-engineering with T cell receptor (TCR) derived from TR-CD4 produced large numbers of functional TR-CD4. These observations provide mechanistic insights into the role of TR-CD4 in tumor immunity, and suggest that approaches to utilize TR-CD4 will augment anti-tumor immune responses for durable therapeutic efficacy in cancer patients

Quenched Approximation Artifacts: A study in 2-dimensional QED

The spectral properties of the Wilson-Dirac operator in 2-dimensional QED responsible for the appearance of exceptional configurations in quenched simulations are studied in detail. The mass singularity structure of the quenched functional integral is shown to be extremely compicated, with multiple branch points and cuts. The connection of lattice topological charge and exactly real eigenmodes is explored using cooling techniques. The lattice volume and spacing dependence of these modes is studied, as is the effect of clover improvement of the action. A recently proposed modified quenched approximation is applied to the study of meson correlators, and the results compared with both naive quenched and full dynamical calculations of the same quantity.Comment: 34 pages (Latex) plus 9 embedded figures; title change