The 3d left ventricular geometry integrated in myocardial wall stress estimation is more sensitive than end diastolic mass/volume ratio to characterize afterload-related left ventricular remodeling

POSTER PRESENTATIONInternational audienc

Evaluation of aortic valve stenosis from Phase-Contrast Magnetic Resonance data using a new automated segmentation and analysis method: Comparison against Doppler Echocardiography

International audiencen.

Age-related changes in tricuspid inflow: comparison between phase contrast MR imaging and Doppler echocardiography

International audiencen.

Age-related variations in left ventricular diastolic parameters assessed automatically from phase-contrast cardiovascular magnetic resonance data: comparison against doppler echocardiography

International audienceRelationship with age and comparison of phase-contrast- CMR and Doppler-echocardiography derived left ventricular diastolic function parameters in asymptomatic individuals with preserved ejection fraction

Measuring aortic distensibility with cmr using central pressures estimated in the magnet: comparison with carotid and peripheral pressures

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Automated left ventricular diastolic function evaluation from phase-contrast cardiovascular magnetic resonance and comparison with Doppler echocardiography

International audienceBACKGROUND: Early detection of diastolic dysfunction is crucial for patients with incipient heart failure. Although this evaluation could be performed from phase-contrast (PC) cardiovascular magnetic resonance (CMR) data, its usefulness in clinical routine is not yet established, mainly because the interpretation of such data remains mostly based on manual post-processing. Accordingly, our goal was to develop a robust process to automatically estimate velocity and flow rate-related diastolic parameters from PC-CMR data and to test the consistency of these parameters against echocardiography as well as their ability to characterize left ventricular (LV) diastolic dysfunction. RESULTS: We studied 35 controls and 18 patients with severe aortic valve stenosis and preserved LV ejection fraction who had PC-CMR and Doppler echocardiography exams on the same day. PC-CMR mitral flow and myocardial velocity data were analyzed using custom software for semi-automated extraction of diastolic parameters. Inter-operator reproducibility of flow pattern segmentation and functional parameters was assessed on a sub-group of 30 subjects. The mean percentage of overlap between the transmitral flow segmentations performed by two independent operators was 99.7 ± 1.6%, resulting in a small variability ( 0.71) and receiver operating characteristic (ROC) analysis revealed their ability to separate patients from controls, with sensitivity > 0.80, specificity > 0.80 and accuracy > 0.85. Slight superiority in terms of correlation with echocardiography (r = 0.81) and accuracy to detect LV abnormalities (sensitivity > 0.83, specificity > 0.91 and accuracy > 0.89) was found for the PC-CMR flow-rate related parameters. CONCLUSIONS: A fast and reproducible technique for flow and myocardial PC-CMR data analysis was successfully used on controls and patients to extract consistent velocity-related diastolic parameters, as well as flow rate-related parameters. This technique provides a valuable addition to established CMR tools in the evaluation and the management of patients with diastolic dysfunction