Parallax and Kinematics of PSR B0919+06 from VLBA Astrometry and Interstellar Scintillometry

Results are presented from a long-term astrometry program on PSR B0919+06 using the NRAO Very Long Baseline Array. With ten observations (seven epochs) between 1994--2000, we measure a proper motion of 18.35 +/- 0.06 mas/yr in RA, 86.56 +/- 0.12 mas/yr in Dec, and a parallax of 0.83 +/- 0.13 mas (68% confidence intervals). This yields a pulsar distance of 1.21 +/- 0.19 kpc, making PSR B0919+06 the farthest pulsar for which a trigonometric parallax has been obtained, and the implied pulsar transverse speed is 505 +/- 80 km/s. Combining the distance estimate with interstellar scintillation data spanning 20 years, we infer the existence of a patchy or clumpy scattering screen along the line of sight in addition to the distributed electron density predicted by models for the Galaxy, and constrain the location of this scattering region to within about 250 parsecs of the Sun. Comparison with the lines of sight towards other pulsars in the same quadrant of the Galaxy permits refinement of our knowledge of the local interstellar matter in this direction.Comment: 12 pages, includes 4 figures and 3 tables, uses AASTeX 5 (included); ApJ submitte

HD 178892 - a cool Ap star with extremely strong magnetic field

We report a discovery of the Zeeman resolved spectral lines, corresponding to the extremely large magnetic field modulus =17.5 kG, in the cool Ap star HD 178892. The mean longitudinal field of this star reaches 7.5 kG, and its rotational modulation implies the strength of the dipolar magnetic component Bp>=23 kG. We have revised rotation period of the star using the All Sky Automated Survey photometry and determined P=8.2478 d. Rotation phases of the magnetic and photometric maxima of the star coincide with each other. We obtained Geneva photometric observation of HD 178892 and estimated Teff=7700+/-250 K using photometry and the hydrogen Balmer lines. Preliminary abundance analysis reveals abundance pattern typical of rapidly oscillating Ap stars.Comment: Accepted by Astronomy & Astrophysics; 4 pages, 4 figure

Parallax of PSR J1744-1134 and the Local Interstellar Medium

We present the annual trigonometric parallax of PSR J1744-1134 derived from an analysis of pulse times of arrival. The measured parallax, pi = 2.8+/-0.3 mas ranks among the most precisely determined distances to any pulsar. The parallax distance of 357+/-39 pc is over twice that derived from the dispersion measure using the Taylor & Cordes model for the Galactic electron distribution. The mean electron density in the path to the pulsar, n_e = (0.0088 +/- 0.0009) cm^{-3}, is the lowest for any disk pulsar. We have compared the n_e for PSR J1744-1134 with those for another 11 nearby pulsars with independent distance estimates. We conclude that there is a striking asymmetry in the distribution of electrons in the local interstellar medium. The electron column densities for pulsars in the third Galactic quadrant are found to be systematically higher than for those in the first. The former correlate with the position of the well known local HI cavity in quadrant three. The excess electrons within the cavity may be in the form of HII clouds marking a region of interaction between the local hot bubble and a nearby superbubble.Comment: revised version accepted for publication in ApJ Letters; reanalysis of uncertainty in parallax measure and changes to fig

Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following ischemic stroke

CD163 is a scavenger receptor expressed on innate immune cell populations which can be shed from the plasma membrane via the metalloprotease ADAM17 to generate a soluble peptide with lympho-inhibitory properties. The purpose of this study was to investigate CD163 as a possible effector of stroke-induced adaptive immune system suppression. Liquid biopsies were collected from ischemic stroke patients (n = 39), neurologically asymptomatic controls (n = 20), and stroke mimics (n = 20) within 24 hours of symptom onset. Peripheral blood ADAM17 activity and soluble CD163 levels were elevated in stroke patients relative to non-stroke control groups, and negatively associated with post-stroke lymphocyte counts. Subsequent in vitro experiments suggested that this stroke-induced elevation in circulating soluble CD163 likely originates from activated monocytic cells, as serum from stroke patients stimulated ADAM17-dependant CD163 shedding from healthy donor-derived monocytes. Additional in vitro experiments demonstrated that stroke-induced elevations in circulating soluble CD163 can elicit direct suppressive effects on the adaptive immune system, as serum from stroke patients inhibited the proliferation of healthy donor-derived lymphocytes, an effect which was attenuated following serum CD163 depletion. Collectively, these observations provide novel evidence that the innate immune system employs protective mechanisms aimed at mitigating the risk of post-stroke autoimmune complications driven by adaptive immune system overactivation, and that CD163 is key mediator of this phenomenon

Machine-Learning Approach Identifies a Pattern of Gene Expression in Peripheral Blood that can Accurately Detect Ischaemic Stroke

Early and accurate diagnosis of stroke improves the probability of positive outcome. The objective of this study was to identify a pattern of gene expression in peripheral blood that could potentially be optimised to expedite the diagnosis of acute ischaemic stroke (AIS). A discovery cohort was recruited consisting of 39 AIS patients and 24 neurologically asymptomatic controls. Peripheral blood was sampled at emergency department admission, and genome-wide expression profiling was performed via microarray. A machine-learning technique known as genetic algorithm k-nearest neighbours (GA/kNN) was then used to identify a pattern of gene expression that could optimally discriminate between groups. This pattern of expression was then assessed via qRT-PCR in an independent validation cohort, where it was evaluated for its ability to discriminate between an additional 39 AIS patients and 30 neurologically asymptomatic controls, as well as 20 acute stroke mimics. GA/kNN identified 10 genes (ANTXR2, STK3, PDK4, CD163, MAL, GRAP, ID3, CTSZ, KIF1B and PLXDC2) whose coordinate pattern of expression was able to identify 98.4% of discovery cohort subjects correctly (97.4% sensitive, 100% specific). In the validation cohort, the expression levels of the same 10 genes were able to identify 95.6% of subjects correctly when comparing AIS patients to asymptomatic controls (92.3% sensitive, 100% specific), and 94.9% of subjects correctly when comparing AIS patients with stroke mimics (97.4% sensitive, 90.0% specific). The transcriptional pattern identified in this study shows strong diagnostic potential, and warrants further evaluation to determine its true clinical efficacy

ASCA Observations of the Thermal Composite Supernova Remnant 3C 391

We present the results from ASCA observations of the centrally enhanced supernova remnant 3C 391 (G31.9+0.0). We use the ASCA SIS data to carry out an investigation of the spatial and spectral properties of the X-ray emission from this remnant. The collisional equilibrium ionization and non-equilibrium ionization spectral fits indicate that the hot gas within the remnant has basically reached ionization equilibrium. The variation of the hydrogen column density across the remnant is in agreement with the presence of a molecular cloud to the northwest. The comparisons of hydrogen column and X-ray hardness between the NW and SE portions of the remnant support a scenario in which the SNR has broken out of a dense region into an adjacent region of lower density. The mean density within the SNR is observed to be much lower than the immediate ambient cloud density. This and the centrally brightened X-ray morphology can be explained either by the evaporation of engulfed cloudlets or by a radiative stage of evolution for the remnant.Comment: 23 pages, 3 figures, accepted for the v563 ApJ 12/10/01 issu

Ultraviolet Imaging Polarimetry of the Large Magellanic Cloud. II. Models

Motivated by new sounding-rocket wide-field polarimetric images of the Large Magellanic Cloud, we have used a three-dimensional Monte Carlo radiation transfer code to investigate the escape of near-ultraviolet photons from young stellar associations embedded within a disk of dusty material (i.e. a galaxy). As photons propagate through the disk, they may be scattered or absorbed by dust. Scattered photons are polarized and tracked until they escape to be observed; absorbed photons heat the dust, which radiates isotropically in the far-infrared, where the galaxy is optically thin. The code produces four output images: near- UV and far-IR flux, and near-UV images in the linear Stokes parameters Q and U. From these images we construct simulated UV polarization maps of the LMC. We use these maps to place constraints on the star + dust geometry of the LMC and the optical properties of its dust grains. By tuning the model input parameters to produce maps that match the observed polarization maps, we derive information about the inclination of the LMC disk to the plane of the sky, and about the scattering phase function g. We compute a grid of models with i = 28 deg., 36 deg., and 45 deg., and g = 0.64, 0.70, 0.77, 0.83, and 0.90. The model which best reproduces the observed polarization maps has i = 36 +2/-5 degrees and g ~0.7. Because of the low signal-to-noise in the data, we cannot place firm constraints on the value of g. The highly inclined models do not match the observed centro-symmetric polarization patterns around bright OB associations, or the distribution of polarization values. Our models approximately reproduce the observed ultraviolet photopolarimetry of the western side of the LMC; however, the output images depend on many input parameters and are nonunique.Comment: Accepted to AJ. 20 pages, 7 figure

Microphysical and thermodynamic phase analyses of Arctic low-level clouds measured above the sea ice and the open ocean in spring and summer

Abstract. Airborne in situ cloud measurements were carried out over the northern Fram Strait between Greenland and Svalbard in spring 2019 and summer 2020. In total, 811 min of low-level cloud observations were performed during 20 research flights above the sea ice and the open Arctic ocean with the Polar 5 research aircraft of the Alfred Wegener Institute. Here, we combine the comprehensive in situ cloud data to investigate the distributions of particle number concentration N, effective diameter Deff, and cloud water content CWC (liquid and ice) of Arctic clouds below 500 m altitude, measured at latitudes between 76 and 83∘ N. We developed a method to quantitatively derive the occurrence probability of their thermodynamic phase from the combination of microphysical cloud probe and Polar Nephelometer data. Finally, we assess changes in cloud microphysics and cloud phase related to ambient meteorological conditions in spring and summer and address effects of the sea ice and open-ocean surface conditions. We find median N from 0.2 to 51.7 cm−3 and about 2 orders of magnitude higher N for mainly liquid clouds in summer compared to ice and mixed-phase clouds measured in spring. A southerly flow from the sea ice in cold air outbreaks dominates cloud formation processes at temperatures mostly below −10 ∘C in spring, while northerly warm air intrusions favor the formation of liquid clouds at warmer temperatures in summer. Our results show slightly higher N in clouds over the sea ice compared to the open ocean, indicating enhanced cloud formation processes over the sea ice. The median CWC is higher in summer (0.16 g m−3) than in spring (0.06 g m−3), as this is dominated by the available atmospheric water content and the temperatures at cloud formation level. We find large differences in the particle sizes in spring and summer and an impact of the surface conditions, which modifies the heat and moisture fluxes in the boundary layer. By combining microphysical cloud data with thermodynamic phase information from the Polar Nephelometer, we find mixed-phase clouds to be the dominant thermodynamic cloud phase in spring, with a frequency of occurrence of 61 % over the sea ice and 66 % over the ocean. Pure ice clouds exist almost exclusively over the open ocean in spring, and in summer the cloud particles are most likely in the liquid water state. The comprehensive low-level cloud data set will help us to better understand the role of clouds and their thermodynamic phase in the Arctic radiation budget and to assess the performance of global climate models in a region of the world with the strongest anthropogenic climate change. </jats:p

Comprehensive study of the magnetic stars HD 5797 and HD 40711 with large chromium and iron overabundances

We present the results of a comprehensive study of the chemically peculiar stars HD 5797 and HD 40711. The stars have the same effective temperature, Teff = 8900 K, and a similar chemical composition with large iron (+1.5 dex) and chromium (+3 dex) overabundances compared to the Sun. The overabundance of rare-earth elements typically reaches +3 dex. We have measured the magnetic field of HD 5797. The longitudinal field component Be has been found to vary sinusoidally between -100 and +1000 G with a period of 69 days. Our estimate of the evolutionary status of the stars suggests that HD 5797 and HD 40711, old objects with an age t \approx 5 \times 108 yr, are near the end of the core hydrogen burning phase.Comment: 26 pages, 5 Encapsulated Postscript figure