29 research outputs found
Representative examples of putative causes of death identified with minimally invasive autopsy sampling.
<p>A) Meningoencephalitis (hematoxylin and eosin, 200x); B) <i>Pneumocysttis jiroveci</i> pneumonia (hematoxylin and eosin, 200x); C) <i>Cryptococcus neoformans</i> infecting the lung (PAS metenamine silver stain, 200x); D) Kaposi’s sarcoma involving the lung (hematoxylin and eosin, 100x).</p
Representative image of the samples obtained from the central nervous system (A), liver (B), bone marrow (C) and lungs/heart and kidney (D) in the minimally invasive autopsy procedure.
<p>Representative image of the samples obtained from the central nervous system (A), liver (B), bone marrow (C) and lungs/heart and kidney (D) in the minimally invasive autopsy procedure.</p
Type and main characteristics of the different needles used in the minimally invasive autopsy procedure for each particular biopsy, puncture sites and number of samples to be obtained.
<p><sup>#</sup> Becton Dickinson, FranklinLakes, NJ, USA</p><p><sup>##</sup>KAI Europe GMBH, Solingen, Germany</p><p>* BARD Biopsy Systems, Tempe, AZ; USA</p><p>**Mana-Tech Ltd, Staffordshire, UK</p><p>*** HS Hospital Service S.P.A, Rome, Italy</p><p>The organ tissues are presented in the order in which the samples were collected.</p
Age, sex, HIV status and pathological and microbiological diagnoses obtained in the 30 minimally invasive autopsies (MIA) performed in the pilot study.
<p>M: male; F: female</p><p>* necrosis and hemorrhage in the cerebral parenchyma with negative stains for microorganisms</p><p><sup>#</sup> etiological agent detected in the pathology sample by immunohistochemistry or special stains</p><p>HBV: hepatitis B virus</p><p>HHV-8: human herpes virus 8</p><p>** minimal perivascular inflammatory infiltrate in CNS parenchyma after immunohistochemical analysis against CD45.</p><p>Age, sex, HIV status and pathological and microbiological diagnoses obtained in the 30 minimally invasive autopsies (MIA) performed in the pilot study.</p
Procedures for the collection of cerebrospinal fluid (A), peripheral blood (B), liver (C), lung (D), spleen (E), and the central nervous system biopsy (F) (designed by Xabier Sagasta).
<p>Procedures for the collection of cerebrospinal fluid (A), peripheral blood (B), liver (C), lung (D), spleen (E), and the central nervous system biopsy (F) (designed by Xabier Sagasta).</p
Median area of tissue for histological evaluation obtained from each organ in mm<sup>2</sup>.
<p>Median area of tissue for histological evaluation obtained from each organ in mm<sup>2</sup>.</p
Sensitivity, specificity, and positive and negative predictive values and percentage of false-positive and false-negative diagnoses and cases correctly classified by the minimally invasive autopsy.
<p>Sensitivity, specificity, and positive and negative predictive values and percentage of false-positive and false-negative diagnoses and cases correctly classified by the minimally invasive autopsy.</p
Strength of the evidence of the autopsy findings identified in the complete diagnostic autopsy and the minimally invasive autopsy.
<p>Strength of the evidence of the autopsy findings identified in the complete diagnostic autopsy and the minimally invasive autopsy.</p
Level of certainty of the diagnosis of cause of death obtained by combination of the strength of the evidence of the pathological and microbiological findings.
<p>Level of certainty of the diagnosis of cause of death obtained by combination of the strength of the evidence of the pathological and microbiological findings.</p
Overall study plan showing the procedures performed in the study, the investigators involved, and site and timing of each procedure.
<p>CDA, complete diagnostic autopsy; MIA, minimally invasive autopsy.</p