Potential link between caffeine consumption and pediatric depression: A case-control study

<p>Abstract</p> <p>Background</p> <p>Early-onset depressive disorders can have severe consequences both from developmental and functional aspects. The etiology of depressive disorders is complex and multi-factorial, with an intricate interaction among environmental factors and genetic predisposition. While data from studies on adults suggest that caffeine is fairly safe, effects of caffeine in children, who are in period of rapid brain development, are currently unknown. Furthermore, systematic research addressing the relationship between depressive symptoms in children and caffeine consumption is lacking.</p> <p>The present study examined the effects of caffeine consumption on depressed mood in children with depression and non-depressed participants.</p> <p>Methods</p> <p>Children and adolescents (n = 51) already enrolled in an ongoing longitudinal study, aged 9-12 years, were assessed for depressive symptoms with the Children Depressive Inventory (CDI). Psychopathological symptoms were assessed with the Child Behavioral Checklist (CBCL) and eating habits were assessed with the Nutrition-Behavior Inventory (NBI) <abbrgrp><abbr bid="B1">1</abbr></abbrgrp>. The children were compared to control children without psychopathology attending public schools in a Southern Brazilian city.</p> <p>Results</p> <p>Participants with CDI scores ≥ 15 (mean = 19; S.D. = 4) also had high NBI scores (mean = 52; S.D. = 19, p < 0.001) suggestive of a relationship between depressive symptoms and environmental factors, in this case nutrition/behavior. Additional linear regression adjusted statistical analysis, considering the factors of consumption of sweets and caffeine individually, showed that caffeine, but not sweets, was associated with depressive symptoms.</p> <p>Conclusions</p> <p>These findings indicate that depressed children consume more caffeinated drinks than non-depressed children. Nonetheless while a strong association between depressive symptoms and caffeine consumption among children was found, further research should investigate whether or not this association is due to a cause and effect relationship.</p

Yield and water use efficiency of cowpea under water deficit

ABSTRACT The state of Pará is the main regional producer of cowpea, but its yield is still low compared to other states of the Northern region such as Amazonas and Tocantins, due to the management adopted and the water regime during the cycle, since its cultivation is conducted on a rainfed basis. The objective of this study was to evaluate how water deficit imposed during reproductive stage interferes in the yield of cowpea and in its water use efficiency under the climatic conditions of Castanhal, Pará, Brazil, for agricultural planning purposes. The experiment was carried out in Castanhal, northeastern region of the Pará state during the dry season of 2014, 2015 and 2016. The experimental design was randomized blocks with six blocks and four treatments, corresponding to different irrigation depths in the reproductive stage, defined as 100, 50, 25 and 0% of the crop evapotranspiration. Water use efficiency (WUE) was determined by the ratio between total grain yield and total water used in each treatment. Maximum water availability led to an average increase in yield of 58% compared to the treatment without irrigation. Water depths below 260 mm limited yield to values lower than 1,000 kg ha-1. The cultivar adopted had WUE of 4.63 kg ha-1 mm-1, in response to the higher levels of water supply, but showed WUE of 4.31 kg ha-1 mm-1 under water depth of 50% of water demand