19,171 research outputs found
Pituitary-adrenal axis in Prader Willi syndrome
Purpose: Prader Willi syndrome (PWS) is a rare genetic condition that has concurrent endocrinological insufficiencies. The presence of growth hormone deficiency has been well documented, but adrenal insufficiency (AI) is not widely reported. A review was conducted to investigate its prevalence and relevance in PWS in both adults and children. Methodology: A literature review was performed with the search terms “Prader-Willi syndrome” and “adrenal insufficiency”. Results: The review found studies disagree on the prevalence and method of investigation of AI in PWS. Case studies demonstrate that patients with PWS are at risk of premature death, often secondary to respiratory infections. The possibility that this may be the result of the inability to mount an effective cortisol response has been studied, with some evidence confirming AI in PWS patients. Most reports agreed AI is present in PWS, however, Farholt et al. showed no HPA axis dysfunction in adults, suggesting that perhaps it is rare in adults, and children should be the focus of further studies. Conclusion: AI is present in some patients with PWS. Further research is required to ensure optimal treatment can be implemented and to prevent premature deaths related to adrenal insufficiency. Clinicians should have a low threshold for testing the adrenal axis and considering treatment for adrenal insufficiency in PWS patients
Clustering of spectra and fractals of regular graphs
We exhibit a characteristic structure of the class of all regular graphs of
degree d that stems from the spectra of their adjacency matrices. The structure
has a fractal threadlike appearance. Points with coordinates given by the mean
and variance of the exponentials of graph eigenvalues cluster around a line
segment that we call a filar. Zooming-in reveals that this cluster splits into
smaller segments (filars) labeled by the number of triangles in graphs. Further
zooming-in shows that the smaller filars split into subfilars labelled by the
number of quadrangles in graphs, etc. We call this fractal structure,
discovered in a numerical experiment, a multifilar structure. We also provide a
mathematical explanation of this phenomenon based on the Ihara-Selberg trace
formula, and compute the coordinates and slopes of all filars in terms of
Bessel functions of the first kind.Comment: 10 pages, 5 figure
Relativistic general-order coupled-cluster method for high-precision calculations: Application to Al+ atomic clock
We report the implementation of a general-order relativistic coupled-cluster
method for performing high-precision calculations of atomic and molecular
properties. As a first application, the static dipole polarizabilities of the
ground and first excited states of Al+ have been determined to precisely
estimate the uncertainty associated with the BBR shift of its clock frequency
measurement. The obtained relative BBR shift is -3.66+-0.44 for the 3s^2
^1S_0^0 --> 3s3p ^3P_0^0 transition in Al+ in contrast to the value obtained in
the latest clock frequency measurement, -9+-3 [Phys. Rev. Lett. 104, 070802
(2010)]. The method developed in the present work can be employed to study a
variety of subtle effects such as fundamental symmetry violations in atoms.Comment: 4 pages, 3 tables, submitte
Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications
The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone induces genomic and non-genomic effects respectively. AR is widely distributed in several tissues, including vascular endothelial and smooth muscle cells. Androgens are essential for many developmental and physiological processes, especially in male reproductive tissues. It is now clear that androgens have multiple actions besides sex differentiation and sexual maturation and that many physiological systems are influenced by androgens, including regulation of cardiovascular function [nitric oxide (NO) release, Ca2+ mobilization, vascular apoptosis, hypertrophy, calcification, senescence and reactive oxygen species (ROS) generation]. This review focuses on evidence indicating that interplay between genomic and non-genomic actions of testosterone may influence cardiovascular function
A simple interpretation of quantum mirages
In an interesting new experiment the electronic structure of a magnetic atom
adsorbed on the surface of Cu(111), observed by STM, was projected into a
remote location on the same surface. The purpose of the present paper is to
interpret this experiment with a model Hamiltonian, using ellipses of the size
of the experimental ones, containing about 2300 atoms. The charge distribution
for the different wavefunctions is analyzed, in particular, for those with
energy close to the Fermi energy of copper Ef. Some of them show two symmetric
maxima located on the principal axis of the ellipse but not necessarily at the
foci. If a Co atom is adsorbed at the site where the wavefunction with energy
has a maximum and the interaction is small, the main effect of the
adsorbed atom will be to split this particular wavefunction in two. The total
charge density will remain the same but the local density of states will
present a dip at Ef at any site where the charge density is large enough. We
relate the presence of this dip to the observation of quantum mirages. Our
interpretation suggests that other sites, apart from the foci of the ellipses,
can be used for projecting atomic images and also indicates the conditions for
other non magnetic adsorbates to produce mirages.Comment: 3 pages, 3 Fig
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HoloCam: A subsea holographic camera for recording marine organisms and particles
The HoloCam system is a major component of a multi-national multi-discipline project known as HoloMar (funded by the European Commission under the MAST III initiative). The project is concerned with the development of pulsed laser holography to analyse and monitor the populations of living organisms and inanimate particles within the world's oceans. We describe here the development, construction and evaluation of a prototype underwater camera, the purpose of which is to record marine organisms and particles, in-situ. Recording using holography provides several advantages over conventional sampling methods in that it allows non-intrusive, non-destructive, high-resolution imaging of large volumes (up to 10^5 cm^3) in three dimensions. The camera incorporates both in-line and off-axis holographic techniques, which allows particles from a few micrometres to tens of centimetres to be captured. In tandem with development of the HoloCam, a dedicated holographic replay system and an automated data extraction and image processing facility are being developed. These will allow, optimisation of the images recorded by the camera, identification of species and particle concentration plotting
Higher physical fitness levels are associated with less language decline in healthy ageing
Healthy ageing is associated with decline in cognitive abilities such as
language. Aerobic fitness has been shown to ameliorate decline in some
cognitive domains, but the potential benefits for language have not been
examined. In a cross-sectional sample, we investigated the relationship between
aerobic fitness and tip-of-the-tongue states. These are among the most frequent
cognitive failures in healthy older adults and occur when a speaker knows a
word but is unable to produce it. We found that healthy older adults indeed
experience more tip-of-the-tongue states than young adults. Importantly, higher
aerobic fitness levels decrease the probability of experiencing
tip-of-the-tongue states in healthy older adults. Fitness-related differences
in word finding abilities are observed over and above effects of age. This is
the first demonstration of a link between aerobic fitness and language
functioning in healthy older adults
Eliminating the d=5 proton decay operators from SUSY GUTs
A general analysis is made of the question whether the d=5 proton decay
operators coming from exchange of colored Higgsinos can be completely
eliminated in a natural way in supersymmetric grand unified models. It is shown
that they can indeed be in SO(10) while at the same time naturally solving the
doublet-triplet splitting problem, having only two light Higgs doublets, and
using no more than a single adjoint Higgs field. Accomplishing all of this
requires that the vacuum expectation value of the adjoint Higgs field be
proportional to the generator I_{3R} rather than to B-L, as is usually assumed.
It is shown that such models can give realistic quark and lepton masses. We
also point out a new mechanism for solving the \mu problem in the context of
SO(10) SUSY GUTs.Comment: 24 pages in LaTeX, with 3 figure
Deficiency in clonogenic endometrial mesenchymal stem cells in obese women with reproductive failure – a pilot study
The mechanisms of obesity associated reproductive complications remain poorly understood. Endometrial mesenchymal stem-cells are critical for cyclic renewal and uterine function. Recently, W5C5+ cells, with high clonogenicity, capable of producing endometrial stroma in vivo, have been described. We sought to investigate the abundance and cloning efficiency of W5C5+ and W5C5− endometrial cells in relation to Body Mass Index, age and reproductive outcome.
Design
W5C5+ and W5C5− cells were purified from mid-luteal endometrial biopsies (n = 54) by magnetic bead separation and subjected to in vitro colony-forming assays.
Results
First trimester pregnancy losses were significantly higher in obese subjects (n = 12) compared to overweight (n = 20) and subjects with normal Body Mass Index (n = 22) (P0.05).
Conclusions
Our observations suggest that the regenerative capacity and plasticity of the endometrium of obese women is suboptimal, which in turn may account for the increased risk of reproductive complications associated with obesity
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