The influence of ANOS1 gene on the survival of patients with colorectal cancer.

<p>The influence of ANOS1 gene on the survival of patients with colorectal cancer.</p

The continuous increase in the expression level of ANOS1 gene during the progression of colorectal cancer; however, the methylation level continues to decrease as colorectal cancer progresses in patients.

<p>The continuous increase in the expression level of ANOS1 gene during the progression of colorectal cancer; however, the methylation level continues to decrease as colorectal cancer progresses in patients.</p

Associations between tertiles of genetic risk score and type 2 diabetes risk in HPFS.

<p>Associations between tertiles of genetic risk score and type 2 diabetes risk in HPFS.</p

As shown in the figure for the protein interaction between ANOS1 and CTHRC1, they might interact with each other via YWHAE.

<p>As shown in the figure for the protein interaction between ANOS1 and CTHRC1, they might interact with each other via YWHAE.</p

The underlying molecular mechanism through which ANOS1 participates in the regulation of Wnt signaling pathway.

<p>The underlying molecular mechanism through which ANOS1 participates in the regulation of Wnt signaling pathway.</p

The enrichment of biological processes in the high expression group of ANOS1 gene.

<p>The enrichment of biological processes in the high expression group of ANOS1 gene.</p

Associations of SNPs in <i>TPMRSS6</i>, <i>HFE</i>, and <i>TF</i> genes with the risk T2D in NHS and HPFS.

*<p>Adjusted for age, BMI (<23.0, 23.0–24.9, 25.0–29.9, 30.0–34.9, or ≥35.0 kg/m² ), family history of diabetes (yes, no), smoking (never, past, current), alcohol (nondrinker or drinker [0.1–4.9, 5.0–9.9, 10.0–14.9 or ≥15.0 g/day]), menopausal status [pre- or post-menopausal (never, past, or current hormone use); women only], quintiles of physical activity (metabolic equivalent task hours/wk for men in HPFS, hours/wk for women in NHS), and quintiles of energy adjusted P:S ratio, <i>trans</i>-fat and cereal fiber intakes.</p

Risk factor characteristics of T2D cases and controls at baseline in NHS and HPFS^*.

*<p>Values are means (SD) unless otherwise indicated. BMI  =  body mass index; PMH  =  post-menopausal hormone.</p>†<p>Test of differences between cases and controls: χ2 for categorical and T-tests for continuous variables.</p>‡<p>Metabolic equivalent task hours/wk for men in HPFS and hours/wk for women in NHS.</p

Associations between body iron status and the SNPs in <i>TPMRSS6</i>, <i>HFE</i>, and <i>TF</i> genes in NHS.

*<p>the first allele of each SNP is effect allele.</p

Clinical characteristics of the participants by gender.

<p>Data are means ± standard deviations for the continuous variables and percentage for the categorical variables.</p