DNA Immunization for HIV Vaccine Development

DNA vaccination has been studied in the last 20 years for HIV vaccine research. Significant experience has been accumulated in vector design, antigen optimization, delivery approaches and the use of DNA immunization as part of a prime-boost HIV vaccination strategy. Key historical data and future outlook are presented. With better understanding on the potential of DNA immunization and recent progress in HIV vaccine research, it is anticipated that DNA immunization will play a more significant role in the future of HIV vaccine development

Latent Semantic Learning with Structured Sparse Representation for Human Action Recognition

This paper proposes a novel latent semantic learning method for extracting high-level features (i.e. latent semantics) from a large vocabulary of abundant mid-level features (i.e. visual keywords) with structured sparse representation, which can help to bridge the semantic gap in the challenging task of human action recognition. To discover the manifold structure of midlevel features, we develop a spectral embedding approach to latent semantic learning based on L1-graph, without the need to tune any parameter for graph construction as a key step of manifold learning. More importantly, we construct the L1-graph with structured sparse representation, which can be obtained by structured sparse coding with its structured sparsity ensured by novel L1-norm hypergraph regularization over mid-level features. In the new embedding space, we learn latent semantics automatically from abundant mid-level features through spectral clustering. The learnt latent semantics can be readily used for human action recognition with SVM by defining a histogram intersection kernel. Different from the traditional latent semantic analysis based on topic models, our latent semantic learning method can explore the manifold structure of mid-level features in both L1-graph construction and spectral embedding, which results in compact but discriminative high-level features. The experimental results on the commonly used KTH action dataset and unconstrained YouTube action dataset show the superior performance of our method.Comment: The short version of this paper appears in ICCV 201

Content Creator versus Brand Advertiser? The Effect of Inserting Advertisements in Videos on Influencers Engagement

Influencer advertising has become an indispensable component of online marketing due to the exponential growth of social influencers and their influence. Whereas the effectiveness of using influencer endorsements is well studied from the brand or company perspective, how the commercial endorsements affect influencers themselves is an important yet unrevealed question. We empirically examine the instantaneous (measured using live comment sentiment) and longer-term (measured using video feedback and follower number change) influence of inserting advertisements in videos on influencers’ reputation. We further investigate how this effect can be moderated when influencers demonstrate stronger endorsement by showing their faces during advertisements. Our result suggests that inserting advertisements have a negative impact on both instantaneous and longer-term viewer engagement; advertisements with influencers’ face showing moderate the negative effect of advertisements on viewers’ instantaneous response, while the different impact between advertisements with/out influencers showing their faces is not significant in the longer term