594 research outputs found
Calibrating "Cheap Signals" in Peer Review without a Prior
Peer review lies at the core of the academic process, but even
well-intentioned reviewers can still provide noisy ratings. While ranking
papers by average ratings may reduce noise, varying noise levels and systematic
biases stemming from ``cheap'' signals (e.g. author identity, proof length) can
lead to unfairness. Detecting and correcting bias is challenging, as ratings
are subjective and unverifiable. Unlike previous works relying on prior
knowledge or historical data, we propose a one-shot noise calibration process
without any prior information. We ask reviewers to predict others' scores and
use these predictions for calibration. Assuming reviewers adjust their
predictions according to the noise, we demonstrate that the calibrated score
results in a more robust ranking compared to average ratings, even with varying
noise levels and biases. In detail, we show that the error probability of the
calibrated score approaches zero as the number of reviewers increases and is
significantly lower compared to average ratings when the number of reviewers is
small
Plasmonic nano-resonator enhanced one-photon luminescence from single gold nanorods
Strong Stokes and anti-Stokes one-photon luminescence from single gold
nanorods is measured in experiments. It is found that the intensity and
polarization of the Stokes and anti-Stokes emissions are in strong correlation.
Our experimental observation discovered a coherent process in light emission
from single gold nanorods. We present a theoretical mode, based on the concept
of cavity resonance, for consistently understanding both Stokes and anti-Stokes
photoluminescence. Our theory is in good agreement of all our measurements.Comment: 14 pages, 7 figures, 2 table
Effect of anti-CIRP antibody on inflammatory response, tumor formation and abdominal aortic aneurysm in rats
Purpose: To investigate the effect of anti-cold induced RNA binding protein (CIRP) antibody on inflammation, tumor formation and abdominal aortic aneurysm in rats.Methods: Thirty healthy male Wistar rats were assigned to pseudo-operation, abdominal aortic aneurysm model, and anti-CIRP groups, with 10 in each group. The levels of CIRP, TNF- α, monocyte giant cytokine chemokine-1 (MCP-1), Toll-like receptor 4 (TLR4)) and nuclear factor kappaB (NF- κB)were determined compared among the groups.Results: At both 2 and 4 weeks, the expression of CIRP protein in the model group was significantly higher than that in the sham operation group (p < 0.05). At these two time-points, tumor formation and maximum diameter were higher in anti-CIRP and model control rats than in pseudo-operation rats. After 4 weeks of treatment, the protein expressions of TNF- α, MCP-1, TLR4 and NF-κB were higher in anti-CIRP and model control rats than in pseudo-operation rats, but were lower than model control values (p < 0.05).Conclusion: CIRP expression is significantly increased in abdominal aortic aneurysm tissue and serum, and is involved in the onset and progress of abdominal aortic aneurysm. Anti-CIRP antibody therapy effectively suppresses tumorigenesis, and inhibits tumor wall inflammatory reaction viaTLR4/NF-κB pathway. This finding provides a clue and new strategy for the clinical management of abdominal aortic aneurysm.
Keywords: CIRP, Abdominal aortic tumor wall, Inflammatory reaction, Protein expression, Tumor bod
Highly sensitive magnetic properties and large linear magnetoresistance in antiferromagnetic CrxSe(0.875\lex\le1)single crystals
CrxSe (x\le1) is a class of quasi-layered binary compounds with potential
applications in spintronics due to its intriguing antiferromagnetic properties.
In this work, CrxSe single crystals with high Cr content (x=0.87, 0.91 and
0.95) were grown, and their magnetic and transport properties were investigated
in detail. It is found that with small increase of Cr content, the N\'eel
temperature (TN) of the samples can dramatically increase from 147 K to 257 K,
accompanied with obvious changes in the magnetic anisotropy and hysteresis. The
phenomena of field-induced spin-flop transitions were unveiled in these alloys,
indicating their comparatively low anisotropy. The magnetoresistance (MR) of
the three compounds showed positive dependence at low temperatures and
particularly, non-saturated linear positive MR was observed in Cr0.91Se and
Cr0.95Se, with a large value of 16.2% achieved in Cr0.91Se (10K, 9T). The
calculated Fermi surface and MR showed that the quasi-linear MR is a product of
carrier compensation. Our work revealed highly sensitive magnetic and transport
properties in the Cr-Se compounds, which can lay foundation when constructing
further antiferromagnetic spintronic devices based on them
FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration
AbstractUnconventional myosin VIIA (Myo7a) has been known to associate with hereditary deafness. Here we present a novel function of Myo7a by identifying that Myo7a directly interacts with integrin β5 subunit and regulates cell adhesion and motility in an integrin-dependent manner. We found that Myo7a bound to the cytoplasmic tail of integrin β5. Further, we pinpointed an integrin-binding domain at F3 of the first FERM domain and F1 of the second FERM domain. Functionally, Myo7a-induced cell adhesion and migration were mediated by integrin αvβ5. These findings indicated that Myo7a interacts with integrin β5 and selectively promotes integrin αvβ5-mediated cell migration
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