Therapy of cancer by insect cells containing recombinant baculovirus encoding genes

Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that express cytokines. Such compositions may be administered by, for example, direct intratumoral injection into tumors in mammals, resulting in tumor reduction or recission. Another aspect of the claimed invention concerns methods of promoting resistance to the reoccurence of tumors in mammals who have undergone such tumor recission. In a specific aspect of the claimed invention, the mammals are human subjects presenting with various forms of cancer.Board of Regents, University of Texas Syste

AIDing Contraception: HIV and Recent Trends in Abortion Rates

Since the onset of HIV/AIDS awareness in the early 1980s, much attention has centered around the substantial negative effects of the disease throughout the world. This paper provides evidence of a secondary effect the disease has had on sexual behavior in the United States. Using a difference-in-differences estimation framework and state level data, we show that the perceived threat of HIV resulted in a drop in unwanted pregnancies, as demonstrated by a lower incidence of abortions. Our results suggest that each additional reported case of HIV per 1,000 individuals resulted in 85.5 fewer abortions per 1,000 live births.

The impact of organizational stigmatization on the operational risk and performance of overseas subsidiaries: empirical evidence from Chinese multinational enterprises

This study used the global database of events, language, and tone of international public opinion big data to measure organizational stigmatization against China. It then used an econometric model to investigate the impact of organizational stigmatization on the operational risk and performance of overseas subsidiaries of Chinese multinational enterprises. The results show that: (1) organizational stigmatization increases overseas subsidiaries’ operational risk and reduces their operational performance, which is more evident in overseas subsidiaries of state-owned enterprises; (2) the host country’s political stability weakens the organizational stigmatization’s positive impact on overseas subsidiaries’ operational risk. The geographical distance between the home and host countries strengthens organizational stigmatization’s positive impact on overseas subsidiaries’ operational risk; (3) the host country’s political stability and the geographical distance between the home and host countries have no moderating effect on organizational stigmatization and overseas subsidiaries’ operational performance; and (4) organizational stigmatization by the host country reduces overseas subsidiaries’ operational performance via the channel of operational risk. This study innovates the measurement method of organizational stigmatization and lays the foundation for investigating the microeconomic impact of organizational stigmatization from the perspective of overseas subsidiaries