A Guide for Hiring Mature Employees at Ascentria

This paper will explore existing literature on aspects of an intergenerational workplace in a nonprofit organization and provide recommendations for recruiting and retaining older employees for a human service organization, Ascentria Care Alliance, in Worcester, MA. The paper will review research on trends in the nonprofit industry, a comprehensive breakdown of generational workplace values, reasons people are returning to work and effective marketing strategies that appeal to older generations. Marketing strategies specifically will explore best practices for website design, social media usage, and job descriptions. Additionally, this paper will research case studies of nonprofits with successful intergenerational workforce initiatives, as well as best practices for human resource management. The research concludes that the most effective ways for Ascentria to connect with older employees is by creating a culture of respect in the workplace, targeted marketing approaches, specific benefit programs, and community partnerships

Expression and evolutionary divergence of the non-conventional olfactory receptor in four species of fig wasp associated with one species of fig

<p>Abstract</p> <p>Background</p> <p>The interactions of fig wasps and their host figs provide a model for investigating co-evolution. Fig wasps have specialized morphological characters and lifestyles thought to be adaptations to living in the fig's syconium. Although these aspects of natural history are well documented, the genetic mechanism(s) underlying these changes remain(s) unknown. Fig wasp olfaction is the key to host-specificity. The <it>Or83b</it> gene class, an unusual member of olfactory receptor family, plays a critical role in enabling the function of conventional olfactory receptors. Four <it>Or83b</it> orthologous genes from one pollinator (PFW) (<it>Ceratosolen solmsi</it>) and three non-pollinator fig wasps (NPFWs) (<it>Apocrypta bakeri, Philotrypesis pilosa </it>and <it>Philotrypesis </it>sp.) associated with one species of fig (<it>Ficus hispida</it>) can be used to better understand the molecular mechanism underlying the fig wasp's adaptation to its host. We made a comparison of spatial tissue-specific expression patterns and substitution rates of one orthologous gene in these fig wasps and sought evidence for selection pressures.</p> <p>Results</p> <p>A newly identified <it>Or83b </it>orthologous gene was named <it>Or2</it>. Expressions of <it>Or2 </it>were restricted to the heads of all wingless male fig wasps, which usually live in the dark cavity of a fig throughout their life cycle. However, expressions were widely detected in the antennae, legs and abdomens of all female fig wasps that fly from one fig to another for oviposition, and secondarily pollination. Weak expression was also observed in the thorax of PFWs. Compared with NPFWs, the <it>Or2 </it>gene in <it>C. solmsi </it>had an elevated rate of substitutions and lower codon usage. Analyses using Tajima's <it>D</it>, Fu and Li's <it>D* </it>and <it>F* </it>tests indicated a non-neutral pattern of nucleotide variation in all fig wasps. Unlike in NPFWs, this non-neutral pattern was also observed for synonymous sites of <it>Or2 </it>within PFWs.</p> <p>Conclusion</p> <p>The sex- and species-specific expression patterns of <it>Or2 </it>genes detected beyond the known primary olfactory tissues indicates the location of cryptic olfactory inputs. The specialized ecological niche of these wasps explains the unique habits and adaptive evolution of <it>Or2 </it>genes. The <it>Or2 </it>gene in <it>C. solmsi </it>is evolving very rapidly. Negative deviation from the neutral model of evolution reflects possible selection pressures acting on <it>Or2 </it>sequences of fig wasp, particularly on PFWs who are more host-specific to figs.</p

Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1

Candida albicans is an opportunistic fungal pathogen of humans that resides commensally on epithelial surfaces, but can cause inflammation when pathogenic. Resolvins are a class of anti-inflammatory lipids derived from omega-3 polyunsaturated fatty acids (PUFA) that attenuate neutrophil migration during the resolution phase of inflammation. In this report we demonstrate that C. albicans biosynthesizes resolvins that are chemically identical to those produced by human cells. In contrast to the trans-cellular biosynthesis of human Resolvin E1 (RvE1), RvE1 biosynthesis in C. albicans occurs in the absence of other cellular partners. C. albicans biosynthesis of RvE1 is sensitive to lipoxygenase and cytochrome P450 monoxygenase inhibitors. We show that 10nM RvE1 reduces neutrophil chemotaxis in response to IL-8; 1nM RvE1 enhanced phagocytosis of Candida by human neutrophils, as well as intracellular ROS generation and killing, while having no direct affect on neutrophil motility. In a mouse model of systemic candidiasis, RvE1 stimulated clearance of the fungus from circulating blood. These results reveal an inter-species chemical signaling system that modulates host immune functions and may play a role in balancing host carriage of commensal and pathogenic C. albicans

Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1

Candida albicans is an opportunistic fungal pathogen of humans that resides commensally on epithelial surfaces, but can cause inflammation when pathogenic. Resolvins are a class of anti-inflammatory lipids derived from omega-3 polyunsaturated fatty acids (PUFA) that attenuate neutrophil migration during the resolution phase of inflammation. In this report we demonstrate that C. albicans biosynthesizes resolvins that are chemically identical to those produced by human cells. In contrast to the trans-cellular biosynthesis of human Resolvin E1 (RvE1), RvE1 biosynthesis in C. albicans occurs in the absence of other cellular partners. C. albicans biosynthesis of RvE1 is sensitive to lipoxygenase and cytochrome P450 monoxygenase inhibitors. We show that 10nM RvE1 reduces neutrophil chemotaxis in response to IL-8; 1nM RvE1 enhanced phagocytosis of Candida by human neutrophils, as well as intracellular ROS generation and killing, while having no direct affect on neutrophil motility. In a mouse model of systemic candidiasis, RvE1 stimulated clearance of the fungus from circulating blood. These results reveal an inter-species chemical signaling system that modulates host immune functions and may play a role in balancing host carriage of commensal and pathogenic C. albicans

Global energetics of solar powerful events on 6 September 2017

Solar flares and coronal mass ejections (CMEs) are thought to be the most powerful events on the Sun. They can release energy as high as 10^32 erg in tens of minutes,and could produce solar energetic particles (SEPs) in the interplanetary space. We explore global energy budgets of solar major eruptions on 6 September 2017, including the energy partition of a powerful solar flare, the energy budget of the accompanied CME and SEPs. In the wavelength range shortward of 222 nm, a major contribution of the flare radiated energy is in the soft X-ray (SXR) 0.1-7 nm domain. The flare energy radiated at wavelengths of Ly-alpha and middle ultraviolet is larger than that radiated in the extreme ultraviolet wavelength, but it is much less than that radiated in the SXR waveband. The total flare radiated energy could be comparable to the thermal and nonthermal energies. The energies carried by the major flare and its accompanied CME are roughly equal, and they are both powered by the magnetic free energy in the AR NOAA 12673. Moreover, the CME is efficient in accelerating SEPs, and that the prompt component (whether it comes from the solar flare or the CME) contributes only a negligible fraction.Comment: accepted for publication in Research in Astronomy and Astrophysic

Determinants of Organophosphorus Pesticide Urinary Metabolite Levels in Young Children Living in an Agricultural Community

Organophosphorus (OP) pesticides are used in agriculture and several are registered for home use. As young children age they may experience different pesticide exposures due to varying diet, behavior, and other factors. We measured six OP dialkylphosphate (DAP) metabolites (three dimethyl alkylphosphates (DMAP) and three diethyl alkylphosphates (DEAP)) in urine samples collected from ∼400 children living in an agricultural community when they were 6, 12, and 24 months old. We examined bivariate associations between DAP metabolite levels and determinants such as age, diet, season, and parent occupation. To evaluate independent impacts, we then used generalized linear mixed multivariable models including interaction terms with age. The final models indicated that DMAP metabolite levels increased with age. DMAP levels were also positively associated with daily servings of produce at 6- and 24-months. Among the 6-month olds, DMAP metabolite levels were higher when samples were collected during the summer/spring versus the winter/fall months. Among the 12-month olds, DMAP and DEAP metabolites were higher when children lived ≤60 meters from an agricultural field. Among the 24-month-olds, DEAP metabolite levels were higher during the summer/spring months. Our findings suggest that there are multiple determinants of OP pesticide exposures, notably dietary intake and temporal and spatial proximity to agricultural use. The impact of these determinants varied by age and class of DAP metabolite