ANALYSIS OF AGOMELATINE TREATMENT WITH DEPRESSIVE SYMPTOMS

Objective: Agomelatine is a new mechanism of antidepressants, which is approved by Taiwan Food and Drug Administration and available in Taiwan.Agomelatine behaves both as a potent agonist at melatonin MT1 and MT2 receptors and as a neutral antagonist at 5-HT2C receptors. The structuresof agomelatine are similar to melatonin with not only the effects to maintain depression symptoms but also can help patients who have insomnia.Methods: This is a retrospective study. In a mental hospital in Taoyuan, we analyzed the prescriptions of the outpatients who were prescribedagomelatine to realize the effects of agomelatine and whether the prescriptions were prescribed appropriately.Results: Catastrophic illnesses were found to be associated with significantly used multiple hypnotics (χ2 =22.02, p<0.001). When patients’ ageincreased by 1 year, multiple hypnotics used increased by 1.013 times (Exp(B)=1.013, p<0.01). Catastrophic illnesses were found to be associatedwith significantly used augmentation with other antidepressants (χ2=54.07, p<0.001).Conclusions: Doctors should be evaluating the benefits and risks when they prescribe a medicine to patients, and they should be written in medicalrecord. This study is the hope to provide relevant units as a reference for formulating health policies

An advanced direction reconstruction technique and application to the observation with H.E.S.S.

The High Energy Stereoscopic system (H.E.S.S.) is an array of five imaging atmospheric Cerenkov telescopes which aims at exploring the high energy non-thermal processes in the universe via detecting very high-energy (VHE) gamma rays. In this work, an advanced direction reconstruction algorithm which yields better point spread function (PSF) and sensitivity is developed to cope with the complex morphology analysis in the Large Magellanic Cloud (LMC) region. LMC is a satellite galaxy of Milky Way at the distance of 48 kpc. The relatively short distance makes it a good extra-galactic laboratory for astronomical observation. The H.E.S.S. observation focuses on the three targets hosted in this region: the young supernova remnant SN1987a, the pulsar wind nebula N 157B, and the superbubble 30Dor C. The VHE flux of SN 1987a is predicted at the detectable level for H.E.S.S. but no significant detection is found in the current dataset. An upper limit on the gamma-ray flux is derived for this target. The pulsar wind nebular N 157B is detected, and the spectrum and other physical quantities are derived. The gamma-ray flux shows that it is the most-energetic-ever observed pulsar wind nebula. At the vicinity of N 157B, we find extra gamma-ray excess towards the direction of 30Dor C. The existance of this source is established by detailed morphology studies and its connection to 30Dor C is discussed

Methyl 4-[(5-chloro­pyrimidin-2-yl)carbamo­yl]benzoate

Mol­ecules of the title compound, C13H10ClN3O3, form centrosymmetric dimers via inter­molecular N—H⋯N hydrogen bonds generating an R 2 2(8) motif. The dimers are further connected through an O⋯Cl—C halogen bond [O⋯Cl = 3.233 (1) Å and O⋯Cl—C = 167.33 (1)°] into a chain along [110]. The secondary amide group adopts a cis conformation. Weak C—H⋯N hydrogen bonds among the methyl benzoate and pyrimidyl rings are also observed in the crystal structure

Blind Source Separation of Hemodynamics from Magnetic Resonance Perfusion Brain Images Using Independent Factor Analysis

Perfusion magnetic resonance brain imaging induces temporal signal changes on brain tissues, manifesting distinct blood-supply patterns for the profound analysis of cerebral hemodynamics. We employed independent factor analysis to blindly separate such dynamic images into different maps, that is, artery, gray matter, white matter, vein and sinus, and choroid plexus, in conjunction with corresponding signal-time curves. The averaged signal-time curve on the segmented arterial area was further used to calculate the relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), and mean transit time (MTT). The averaged ratios for rCBV, rCBF, and MTT between gray and white matters for normal subjects were congruent with those in the literature