Ben Snook, The Anglo-Saxon chancery: the history, language and production of Anglo-Saxon charters from Alfred to Edgar

No abstract available

A Blueprint for Early Care and Education Quality Improvement Initiatives: Final Report

As Quality Rating and Improvement Systems (QRIS) continue to launch and mature across states, questions emerge from stakeholders about how to design and implement effective quality improvement (QI) initiatives that accompany a QRIS. Funders, policymakers and program developers with limited resources are looking to invest in activities that will be most successful in supporting early care and education (ECE) program quality improvement and ultimately improving outcomes for young children. The purpose of this report is to address questions about effective QI initiatives by proposing a blueprint of quality improvement practices and design considerations generated from a synthesis of the existing research literature and input from national experts in ECE quality improvement

Worcester and Wales: Copies of the Regula pastoralis in the early Middle Ages

No abstract available

Filling the silence: shared content in four related manuscripts of Ælfric’s catholic homilies

In this article I analyze the contents and transmission of a group of related manuscripts containing copies of Ælfrician and anonymous homilies in order to demonstrate the linguistic potential of variant copies of texts. I consider them from a comparative textual and linguistic perspective in a way that privileges the scribe and scribal activity over traditional philology or editorial practice. The manuscripts are Oxford, Bodleian Library MSS Bodley 340 and 342, Cambridge, Corpus Christi College MSS 162, 198, and 303. They date from Ælfric’s lifetime (c. 950–c. 1010) to the midtwelfth century. I focus on three Ælfrician homilies that appear in sequence uniquely in this cluster alongside four anonymous texts that, similarly, are not found together elsewhere. This research, funded by the Andrew W. Mellon foundation, was conducted as part of a collaborative project that sought to refine digital technologies to aid consequential research in book and language history

Archaeological Survey Of The Sister Grove RWRRF Collin County, Texas

The North Texas Municipal Water District is planning to build the Sister Grove Regional Water Resource Recovery Facility on a 932-acre property in New Hope, Collin County, Texas. In total, 372 acres of this property will be impacted. In a cultural resource evaluation dated September 5, 2019, AR Consultants, Inc. recommended the survey of four areas with high potential for encountering prehistoric and historic archaeology, totaling 105 acres. CDM Smith, Inc. contracted with AR Consultants, Inc. to perform the survey under the authority of Texas Antiquities Permit 9182. Fieldwork occurred on December 4-5, 2019 and January 7, 2020. An addendum to Permit 9182 for the survey of a 4.2-mile-long, 96-inch-diameter pipeline that will connect the water facility to an 18.2-acre outfall property on Stiff Creek, surveyed by AR Consultants, Inc. in 2018, was approved in August 2020. On behalf of AR Consultants, Inc., SWCA Environmental Consultants surveyed 3.8 miles of the 120-foot-wide pipeline corridor between September 9-12, 2020. Based on background research, AR Consultants, Inc. predicted that there was potential for encountering prehistoric and historic cultural resources across the survey area. Seven historic archaeological sites (41COL328-330 and 41COL336-339) and four historic isolated objects were recorded during the survey. The sites include large, repeatedly plowed surficial scatters, many of which correspond with mapped structures, and a trash dump. Only five of the 191 shovel tests yielded artifacts. These sites retain little integrity and are not associated with significant persons, events, or architectural styles. The sites do not have the potential to yield new information about past lifeways or environments. Therefore, these sites are recommended as ineligible for listing on the National Register of Historic Places or designation as State Antiquities Landmarks. Given the results of this survey, AR Consultants, Inc. recommends that further cultural resource investigations are unnecessary for this survey area and request that the Texas Historical Commission and the U.S. Army Corps of Engineers concur with these recommendations. Records associated with this project will be curated with the Center for Archaeological Studies at Texas State University, San Marcos

Filling the Silence: Shared Content in Four Related Manuscripts of Ælfric’s Catholic Homilies

In this article I analyze the contents and transmission of a group of related manuscripts containing copies of Ælfrician and anonymous homilies in order to demonstrate the linguistic potential of variant copies of texts. I consider them from a comparative textual and linguistic perspective in a way that privileges the scribe and scribal activity over traditional philology or editorial practice. The manuscripts are Oxford, Bodleian Library MSS Bodley 340 and 342, Cambridge, Corpus Christi College MSS 162, 198, and 303. They date from Ælfric’s lifetime (c. 950–c. 1010) to the midtwelfth century. I focus on three Ælfrician homilies that appear in sequence uniquely in this cluster alongside four anonymous texts that, similarly, are not found together elsewhere. This research, funded by the Andrew W. Mellon foundation, was conducted as part of a collaborative project that sought to refine digital technologies to aid consequential research in book and language history

Correction: Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding

This is a correction article. After publication of this work [1], we became aware of the fact that Robert C. Speth was not included as an author. Dr. Speth put a considerable amount of time and effort into developing and preparing the radiopeptide used to carry out the radioligand binding studies reported in this manuscript and therefore should have originally been included as an author. We apologize to Dr. Speth for any inconvenience that this oversight might have caused and thank him for his invaluable contribution to this project

Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12

BACKGROUND: Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflammatory cytokines, and haemozoin-containing leucocytes was studied in children with severe falciparum malarial anaemia. METHODS: Twenty-six children with a primary diagnosis of severe malarial anaemia with any asexual Plasmodium falciparum parasite density and Hb < 5 g/dL were studied and the association of plasma lactate levels and haemozoin-containing leucocytes, parasite density, pro- and anti-inflammatory cytokines was measured. The same associations were measured in non-severe malaria controls (N = 60). RESULTS: Parasite density was associated with lactate levels on admission (r = 0.56, P < 0.005). Moreover, haemozoin-containing neutrophils and IL-12 were strongly associated with plasma lactate levels, independently of parasite density (r = 0.60, P = 0.003 and r = -0.46, P = 0.02, respectively). These associations were not found in controls with uncomplicated malarial anaemia. CONCLUSION: These data suggest that blood stage parasites, haemozoin and low levels of IL-12 may be associated with the development of hyperlactataemia in severe malarial anaemia