Cannabis—XV . Pyrolysis of cannabidiol. Structure elucidation of four pyrolytic products

Pyrolysis of cannabidiol in nitrogen atmosphere affords at least six more products with longer GC-retention times than CBD, next to unconverted CBD. Two of these could be identified as Δ1(2)THC and CBN Two further products were investigated and their mass spectrometrical fragmentations and structures are proposed

Neodihydrothebaine and bractazonine, two dibenz[d,f]azonine alkaloids of Papaver bracteatum

Two new dibenz[d,f]azonine alkaloids, neodihydrothebaine and bractazonine were isolated from Papaver bracteatum. Their possible biosynthesis from thebaine is discussed. The structures of both new alkaloids are proven by synthesis. An isomeric dibenz[d,f]azonine compound was also prepared

Toxicity of copper hydroxide, dithianon, fluazinam, tebuconazole and pyraclostrobin to Didymella applanata isolates from Serbia

A study of the in vitro sensitivity of 10 isolates of Didymella applanata to copper hydroxide, dithianon, fluazinam, tebuconazole and pyraclostrobin, was conducted. The isolates were derived from diseased raspberry canes sampled during 2013 at five localities in western part of Serbia, known as the main raspberry growing region of the country. Prior to sensitivity testing experimental conditions for radial growth assay were optimized. The results showed that the temperature of 22 degrees C, oatmeal agar medium and 12/12 hrs light/ darkness light regimen provided the best conditions for sensitivity tests. Most of D. applanata isolates were sensitive to the tested fungicides. The narrowest range of EC50 values was recorded for tebuconazole (1.42-2.66mg L-1). The widest range of EC50 values was obtained for pyraclostrobin, ranging from 0.17mg L-1 to 55.33mg L-1. The EC50 values for the studied isolates were 39.48-51.19mg L-1 for copper hydroxide, 12.12-18.73mg L-1 for dithianon and 5.72-42.56mg L-1 for fluazinam. According to resistance factor values, all D. applanata isolates were sensitive to copper hydroxide, dithianon and tebuconazole. Among tested isolates, six were highly resistant to pyraclostrobin (RFs in the range of 207.1-325.5) and two moderately resistant to fluazinam (RFs were 3 and 7.4), respectively