10 research outputs found
Conditional logistic regression models of HLA-B and of <i>ERAP1</i> haplotypes.
<p>Conditional logistic regression models of HLA-B and of <i>ERAP1</i> haplotypes.</p
<i>ERAP1</i> haplotypes obtained by the combination of the five SNPs included in this study.
<p>Only those haplotypes having frequencies greater than 0.05 are displayed.</p><p>Minor alleles are in bold.</p
Distribution of the five SNPs studied in <i>ERAP1</i> according to a recessive model of the minor allele.
<p>Individuals with the HLA-B risk factors are subjects bearing HLA-B*51 and/or B*57.</p
Conditional logistic regression models of HLA-B and three different conditions of <i>ERAP1</i>.
<p>“Ho” are individuals H2H2,H3H3 and H4H4; “He” are individuals H1H2,H1H3 and H1H4; “dHe” are individuals H2H3,H2H4 and H3H4; “N” are individuals H1H1.</p><p>CI confidence interval.</p
Manhattan plot representation of the Omnibus test on amino acid positions.
<p>A) Unconditioned test. B) Omnibus test conditioning on position 97 of HLA-B. C) Omnibus test conditioning on positions 97 and 66 of HLA-B and HLA-A, respectively. The–log10 of the combined logistic regression test P-values are plotted against the physical chromosomal positions of the centre of codon. The red line represents the threshold for statistical significance (P<3.91E-04).</p
Workflow diagram summarising the methodological process of this study.
<p>*The control set was obtained from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161305#pone.0161305.ref017" target="_blank">17</a>].</p
Novel genetic associations with Behçet’s disease at the genome-wide level of significance in the Spanish population.
<p>Results of the discovery, replication and combined analyses are shown. Chr, chromosome; Freq, allele frequency; OR, odds ratio for the minor allele; CI, confidence interval; BD, Behçet’s disease; CTRL, controls.</p
The most relevant amino acid positions for the susceptibility to Behçet’s disease and those classical HLA variants (at resolution of the first set of digits) most common in our population (frequency >1%) containing the different residues at each position are shown.
<p>The most relevant amino acid positions for the susceptibility to Behçet’s disease and those classical HLA variants (at resolution of the first set of digits) most common in our population (frequency >1%) containing the different residues at each position are shown.</p
Manhattan plot representation of the Immunochip results.
<p>The–log10 of the combined logistic regression test P-values are plotted against its physical chromosomal position. The red line indicate the genome-wide level of significance (P<5x10E-08). The most relevant associations are highlighted. The red dots represent the overall results of <i>IL12A</i> and rs2848479 after the validation phase.</p
Step-wise conditional analysis of imputed classical HLA alleles to detect independent associations with Behçet’s disease.
<p>OR, odds ratio; CI, confidence interval.</p