Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Correction: Volume: 10 Issue: 1 Article Number: 44 DOI: 10.1186/s13601-020-00351-w Published: OCT 26 2020Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.Peer reviewe

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

E-Learning for Deaf Adults from a User-Centered Perspective

Deaf individuals present differences compared to their hearing peers in terms of their learning profile. In addition, deaf adults seem to still be socially excluded nowadays, given that the transition from school to work is more difficult for people with hearing loss. This study aims to analyze the cognitive characteristics of deaf adults, as well as the way they learn better, for the development of an innovative and user-friendly e-learning platform, which will be adapted to the educational needs of the target group. Fifty-three deaf or hard-of-hearing adults participated in the field research for the needs of this study. According to the results, participants prefer e-learning modules with continuity in terms of the content, which offer comprehension questions during the sessions, as well as practice exercises after their completion. Furthermore, participants had positive attitudes towards the use of special graphics and explanatory videos

Hide and mine solver

This repository contains solutions to the Hide and Mine problem. There are separated in two kind, one using an ILP solver (Gurobi) and the others are greedy heuristics. To use them you will need to first install Gurobi (they have free academic licenses available). Both ILP and the heuristics are written in C++ 11

Numerical Check of the Meyerhof Bearing Capacity Equation for Shallow Foundations

In 1920 Prandtl published an analytical solution for the bearing capacity of a strip load on a weightless infinite half-space. This solution was extended with a surrounding surcharge by Reissner and with the soil weight by Keverling Buisman. It was Terzaghi who wrote this with three separate bearing capacity factors for the cohesion, surcharge and soil-weight. Meyerhof extended this to the equation which is nowadays used; with shape and inclination factors. He also proposed equations for the inclination factors, based on his own laboratory experiments. Since then, several people proposed updated equations for the soil-weight bearing capacity factor, and also for the shape and inclination factors. The common idea is that failure of a footing occurs in all cases with a Prandtl-wedge failure mechanism. In order to check the failure mechanisms and the currently used equations for the bearing capacity factors and shape factors, a large number of finite element calculations of strip and circular footings have been made. These calculations proof that for some cases there are also a few other failure mechanisms possible. Also the currently used bearing capacity factors and shape factors are not correct. In fact, for footings on a soil with a higher friction angle, all three bearing capacity factors and all three shape factors can be much lower than the currently used values. This means that the currently used equations for the soil-weight bearing capacity factors and the shape factors are inaccurate and unsafe. Therefore, based on the finite element calculations, new equations have been presented in this paper