UN CARTEGGIO INEDITO TRA MINISTRI. L’ARRESTO DI SIMONIDIS, LE OPERE DI MURALT, TAFEL E THOMAS

Dossier F17/3222 at the Archives Nationales de France consists of eight documents, letters in copy or original, dated between 20 January and 26 July 1856. They concern the arrest in Leipzig of Constantine Simonidis, a well-known forger, and the publication of two works, the Essai de Chronographie Byzantine (1855) by E. von Muralt and the collection of documents on the relations between Venice and Byzan- tium published in Vienna by Tafel and Thomas (1856). The period in which this cor- respondence takes place corresponds to the last phase of the Crimean War and the Congress of Paris, which sanctioned its end with the peace treaty of 30 March 1856. It shows the particular interest aroused by historical works that could provide a justification for European arrangements, looking back to earlier times and justifying con- temporary territorial claims

Heavily treatment-experienced persons living with HIV currently in care in Italy: characteristics, risk factors, and therapeutic options-the ICONA Foundation cohort study

Objectives: Heavily treatment-experienced (HTE) people living with HIV (PLWH) pose unique challenges due to limited antiretroviral treatment (ART) options. Our study aimed to investigate the prevalence and features of HTE individuals followed up in the Italian Cohort Na & iuml;ve Antiretrovirals (ICONA) cohort as of December 31, 2021. Methods: HTE were defined based on meeting specific conditions concerning their current ART and their ART history up to December 31, 2021. Descriptive statistics were performed by HTE status. Regression analyses explored factors associated with becoming HTE based on pre-ART patients' characteristics. Cluster dendrogram analysis provided insights into subgroups with inadequate responses based on clusters of differentiation (CD4) counts and viral load (VL) trajectories. Results: Among the 8758 PLWH actively followed in our cohort, 163 individuals (1.9%), mainly female, younger, Italian, and infected through heterosexual contact, met the HTE criteria. A lower CD4 count at ART initiation (odds ratio [OR] 1.60 per 100 cells/mmc lower CD4, 95% confidence interval [CI] 1.06-2.41, P = 0.03) and hepatitis C virus antibody positivity (OR 1.90, 95% CI 1.16-3.11, P = 0.01) were associated with higher HTE risk. Thirty PLWH exhibited ongoing immune-virological failure (18% of the HTE subgroup and 0.003% of the total population). Thirty PLWH exhibited ongoing immune-virological failure (i.e., with a current CD4 count < 200 cells/mmc or VL > 200 copies/mL). A cluster analysis identified 13 (43%) with a current CD4 count < 200 cells/mmc. Also, notably, 19/30 (63%) had major acquired resistanceassociated mutations to at least one antiretroviral drug class. Conclusions: HTE is rare in our cohort and tends to co-exist with major resistance mutations. A focused investigation into treatment history and immuno-virological response is warranted, particularly given the availability of new antiretroviral drugs

Bilateral renal hemorrhage in an anticoagulated patient: A rare case of Wunderlich syndrome

: We describe a rare case of Wunderlich syndrome with bilateral renal hemorrhage in a patient under anticoagulant therapy for atrial fibrillation. An 84-year-old woman came to our department complaining of acute bilateral flank pain. Clinical and laboratory examinations revealed a condition of hypovolemic shock. An abdominal contrast-enhanced CT scan detected the presence of a bilateral hemorrhage affecting the peri- and para-renal spaces. Planning an appropriate management strategy considering the anticoagulated treatment required a multidisciplinary approach in the case of the Wunderlich syndrome diagnosis

New perspectives on the role of cultural and environmental assets in the territorial socio-economic development processes. The Gargano National Park area

The present research aims to better understand the role of Cultural and Environmental Assets (CEAs) in the processes of socio-economic development of marginalised areas. The theoretical analysis starts from a brief review of the literature. Secondly, the research focuses on a particular marginalised area of the region of Puglia (South of Italy), namely the Gargano area, which is rich in natural resources and cultural traditions. Thirdly, reference is made to the latest technological perspectives in the field of the protection and promotion of CEAs. One of the major gaps of the current literature is the lack of models for development and management of CEAs providing an effective network between public and private systems based on a common regulation to all members of a territory. Also, a lack of geo- referencing by means of a Geographic Information System (GIS) on local scale with information widely shared by local actors is also present. To contribute to close the above gaps, the present study reflects on the criteria established for achieving the status of "integrated" cultural goods, and assesses how and which assets may be geo-referenced. The analysis of the state of the art highlights the need of ad-hoc policies for the implementation of geo-referencing systems as means to strengthen actual regulations that take into account development opportunities as well as more inclusive parameters adapted to the environmental context, and in line with the 2030 Agenda (UN), the Next Generation EU (NGEU) and the National Recovery and Resilience Plan (NRRP)

Educazione migrante tra passato, presente e futuro. Saggi in onore di Leonard Covello

Il volume riunisce i contributi di studiose e di studiosi italiani e americani per ricordare l'eccezionale figura di Leonard Covello pioniere delle strategie inclusive nella scuola statunitense e punto di riferimento per la vasta comunità di immigrati di East Harlem, tra gli anni Venti e Cinquanta del Novecento

Challenging Axillary Lymph Nodes on PET/CT in Cancer Patients throughout COVID-19 Vaccination Era

Background: The unexpected detection of axillary lymphadenopathy (AxL) in cancer patients (pts) represents a real concern during the COVID-19 vaccination era. Benign reactions may take place after vaccine inoculation, which can mislead image interpretation in patients undergoing F-18-FDG, F-18-Choline, and Ga-68-DOTATOC PET/CT. They may also mimic loco-regional metastases or disease. We assessed PET/CT findings after COVID-19 first dose vaccination in cancer patients and the impact on their disease course management. Methods: We evaluated 333 patients undergoing PET/CT (257 F-18-FDG, 54 F-18-Choline, and 23 Ga-68 DOTATOC) scans after the first vaccination with mRNA vaccine (Pfizer-BioNTech) (study group; SG). The uptake index (SUVmax) of suspected AxL was defined as significant when the ratio was > 1.5 as compared to the contralateral lymph nodes. Besides, co-registered CT (Co-CT) features of target lymph nodes were evaluated. Nodes with aggregate imaging positivity were further investigated. Results: Overall, the prevalence of apparently positive lymph nodes on PET scans was 17.1% during the vaccination period. 107 pts of the same setting, who had undergone PET/CT before the COVID-19 pandemic, represented the control group (CG). Only 3 patients of CG showed reactive lymph nodes with a prevalence of 2.8% (p < 0.001 as compared to the vaccination period). 84.2% of SG patients exhibited benign characteristics on co-CT images and only 9 pts needed thorough appraisal. Conclusion: The correct interpretation of images is crucial to avoid unnecessary treatments and invasive procedures in vaccinated cancer pts. A detailed anamnestic interview and the analysis of lymph nodes' CT characteristics, after performing PET/CT, may help to clear any misleading diagnosis. Clinical Trial Registration Number: Protocol # 20210053954/CEUR 118/2021

Radiological diagnosis of prevalent osteoporotic vertebral fracture on radiographs: an interim consensus from a group of experts of the ESSR osteoporosis and metabolism subcommittee

When a low-energy trauma induces an acute vertebral fracture (VF) with clinical symptoms, a definitive diagnosis of osteoporotic vertebral fracture (OVF) can be made. Beyond that, a "gold" radiographic standard to distinguish osteoporotic from non-osteoporotic VFs does not exist. Fracture-shaped vertebral deformity (FSVD) is defined as a deformity radiographically indistinguishable from vertebral fracture according to the best of the reading radiologist's knowledge. FSVD is not uncommon among young populations with normal bone strength. FSVD among an older population is called osteoporotic-like vertebral fracture (OLVF) when the FSVD is likely to be associated with compromised bone strength. In more severe grade deformities or when a vertebra is collapsed, OVF diagnosis can be made with a relatively high degree of certainty by experienced readers. In "milder" cases, OVF is often diagnosed based on a high probability rather than an absolute diagnosis. After excluding known mimickers, singular vertebral wedging in older women is statistically most likely an OLVF. For older women, three non-adjacent minimal grade OLVF (< 20% height loss), one minimal grade OLVF and one mild OLVF (20-25% height loss), or one OLVF with >= 25% height loss, meet the diagnosis of osteoporosis. For older men, a single OLVF with < 40% height loss may be insufficient to suggest the subject is osteoporotic. Common OLVF differential diagnoses include X-ray projection artifacts and scoliosis, acquired and developmental short vertebrae, osteoarthritic wedging, oncological deformities, deformity due to high-energy trauma VF, lateral hyperosteogeny of a vertebral body, Cupid's bow, and expansive endplate, among others