Business-oriented prioritization: A novel graphical technique

Traditionally, Pareto analysis has been used to select the most critical components and failure modes of a system. A clear disadvantage of this technique is that it requires preselecting a single criterion to establish priorities. More recently, a graphical log-scatter diagram technique has been proposed. It considers three key performance indicators simultaneously: reliability (MTBF), maintainability (MTTR), and unavailability (D). This technique considers only times and does not include economical effects explicitly. This article extends both techniques to explicitly consider both direct and indirect costs to prioritize from the point of view of an asset manager or from a maintenance decision-maker, as required. Due to the economic-based approach of this article, cost discounting is also considered inside financial costs such as—but not limited to—reliability-related investments. Also, the results are displayed on simple and accessible graphs which make them particularly useful for conveying results to non-technical managers. The methodology is illustrated by analyzing a shovel from the copper mine industry, and it clearly shows how the proposed technique facilitates business oriented decisions and how they should change under different market conditions

Co-construction of climate services based on a weather stations network: Application in Toulouse agglomeration local authority

International audienc

Demand Control Loops for a Global Spare Parts Management

Part VI: Services, Supply Chains and OperationsInternational audienceTimely, reliable supply of customers with spare parts is a key factor for business success in many branches. In the field of aviation the competition and cost pressures in the MRO sector (Maintenance, Repair and Overhaul) increased strongly in recent decades. Large maintenance organizations offer component pooling services for aircraft operators. A main challenge in the processes of MRO service providers is the calculation of the optimal stock level for pool components. The basis of an optimal inventory planning for the supply of spare parts is the quality of the demand input parameters used for the calculation. This paper describes the processes and the challenges of the MRO spare parts management as well as the approaches of a research project to face these challenges

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an acylguanidine that was developed following a whole-cell screen with compounds known to hit high-value targets in human cells. MMV688533 displays fast parasite clearance in vitro and is not cross-resistant with known antimalarials. In a P. falciparum NSG mouse model, MMV688533 displays a long-lasting pharmacokinetic profile and excellent safety. Selection studies reveal a low propensity for resistance, with modest loss of potency mediated by point mutations in PfACG1 and PfEHD. These proteins are implicated in intracellular trafficking, lipid utilization, and endocytosis, suggesting interference with these pathways as a potential mode of action. This preclinical candidate may offer the potential for a single low-dose cure for malaria