Additional file 1: of Adjuvant trastuzumab duration trials in HER2 positive breast cancer – what results would be practice-changing? Persephone investigator questionnaire prior to primary endpoint results

Trastuzumab Duration questionnaire. The questionnaire that was completed by the oncologists. (PDF 476 kb

Additional file 1: Table S1. of A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities

Patient characteristics of the 6,248 patients shown by trial. Table S2. National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) version 2. Table S3. Case-control classification method for the 13 CRTs investigated. Table S4. Neutropenia and fatigue in relation to outcome, split by different treatment components. Figure S1. Trial objectives, outcomes and treatment regimens of the contributing clinical trials. (DOCX 82 kb

Association of polygenic risk scores with chemotherapy-related neutropenia and taxane-related sensory neuropathy.

<p>Association of polygenic risk scores with chemotherapy-related neutropenia and taxane-related sensory neuropathy.</p

Kaplan-Meier plot comparing relapse-free survival in patients carrying >90 risk alleles to those carrying <80 risk alleles.

<p>Kaplan-Meier plot comparing relapse-free survival in patients carrying >90 risk alleles to those carrying <80 risk alleles.</p

Distribution of chemotherapy-induced neutropenia and taxane-related sensory neuropathy in the PGSNPS sample according to the National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) version 2/3.

<p>Distribution of chemotherapy-induced neutropenia and taxane-related sensory neuropathy in the PGSNPS sample according to the National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) version 2/3.</p

Top 38 genes according to p-value for association between highest-ranking breast cancer risk variant and neutropenia.

<p>Top 38 genes according to p-value for association between highest-ranking breast cancer risk variant and neutropenia.</p

Genetic variants known to influence risk of breast cancer.

<p>Genetic variants known to influence risk of breast cancer.</p