Schematic diagram depicting how caloric intake and deiodinase activity fit into relationships shown in Fig 2.

<p>Higher caloric intake (C) reflects higher weight (A) and induces higher deiodinase activity (D) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149065#pone.0149065.ref032" target="_blank">32</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149065#pone.0149065.ref034" target="_blank">34</a>]. Lower fT4 (E) and higher T3/T4 ratios (F) occur as a consequence of higher deiodinase activity and are associated with both insulin resistance (G) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149065#pone.0149065.ref024" target="_blank">24</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149065#pone.0149065.ref025" target="_blank">25</a>] and gestational diabetes (B).</p

Extent to which variables that differ significantly between women with and without gestational diabetes might influence fT4 concentration (9,079 women without gestational diabetes).

<p>Extent to which variables that differ significantly between women with and without gestational diabetes might influence fT4 concentration (9,079 women without gestational diabetes).</p

Relationships between gestational diabetes (GDM) and age (Fig 1A), weight (Fig 1B), free thyroxine (fT4) (Fig 1C), and thyrotropin (TSH) (Fig 1D).

<p>Open circles represent percents of GDM cases at each decile of the variable shown on the X-axis. Solid lines indicate unadjusted slopes of the respective relationships; p-values indicate slope significance. The dotted line in Fig 1C shows the slope of the fT4/GDM relationship, after adjustment for age, weight, and TSH.</p

Thyrotropin (TSH), free thyroxine (fT4) and thyroperoxidase (TPO) antibodies among women with and without gestational diabetes (GDM).

<p>Thyrotropin (TSH), free thyroxine (fT4) and thyroperoxidase (TPO) antibodies among women with and without gestational diabetes (GDM).</p

Characteristics of women with and without gestational diabetes.

<p>Characteristics of women with and without gestational diabetes.</p