Lower Limb Muscle Activation in Young Adults Walking in Water and on Land

Previous research has shown that exercise interventions requiring increased activation of the tibialis anterior (TA), the primary ankle dorsiflexor, can improve walking performance in individuals with foot drop. Correspondingly, heightened drag forces experienced during walking performed in water may augment TA activation during the swing phase of gait, potentially leading to improved walking gait on land. Therefore, this study aimed to compare surface electromyographic (sEMG) activation in the TA and medial gastrocnemius (GM) during gait performed in water versus on land. Thirty-eight healthy, recreationally active young adults, comprising 18 females and 20 males, participated in the study. Each participant completed 2 min walking trials under five conditions: land 2.5 mph, land 3.5 mph, water 2.5 mph, water 3.5 mph, and water 3.5 mph with added jet resistance. Stride kinematics were collected using 2-dimensional underwater motion capture. TA and GM, muscle activation magnitudes, were quantified using sEMG root-mean-square (RMS) amplitudes for both the swing and stance phases of walking. Additionally, TA and GM co-activation (Co-A) indices were estimated. Two-way within-subjects repeated measures analyses of variance were used to evaluate the main effects of and interactions between the environment and walking speed. Additionally, paired sample t-tests were conducted as a secondary analysis to investigate differences between walking in water at 3.5 mph with and without added jet resistance. Main effects and interactions were observed across various stride kinematics and sEMG measures. Notably, TA sEMG RMS during the swing phase of walking gait performed at 2.5 mph was 15% greater in water than on land (p \u3c 0.001). This effect increased when walking gait was performed at 3.5 mph (94%; p \u3c 0.001) and when jet resistance was added to the 3.5 mph condition (52%; p \u3c 0.001). Furthermore, TA Co-A was increased during the stance phase of gait in water compared to on land (p \u3c 0.001), while GM Co-A was reduced during the swing phase (p \u3c 0.001). The findings of this study offer compelling evidence supporting the efficacy of aquatic treadmill walking as a potential treatment for individuals suffering from foot drop. However, further research is needed to evaluate whether a causal relationship exists between heightened TA activation observed during aquatic treadmill walking and improvements in voluntary dorsiflexion during gait

Not All Cavities Are Treated Equal: Increasing Access to Preventive Dental Care in Texas

The purpose of this report is to examine oral health care for children in Texas. United Ways of Texas is concerned with the disproportionate levels of access that low-income children face. This research team was charged by United Ways to: Develop appropriate measures of access to preventive dental care for children Analyze the geographic and socioeconomic patterns of such access measures in Texas Calculate the expected benefits and costs of expanding access There are significant disparities in access to oral health care for children in Texas. These disparities are frequently based on income levels, ethnic status, and if a child lives in an urban or rural area. Because disparity continues to exist among Texans, this report offers the following recommendations to improve access to dental care. To support these recommendations, this report will: 1. Describe the importance of children's oral health. 2. Show disparities that exist among children. 3. Describe the types of preventive care that can improve children's oral health. 4. Demonstrate that preventive care can be cost-effective. 5. Identify barriers to access in Texas through literature and researchUnited Ways of Texa

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

CAPRISA, 2017.Abstract available in pdf

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.

CAPRISA, 2017.Abstract available in pdf

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations

A strategy for HIV-1 vaccine development is to define envelope (Env) evolution of broadly neutralizing antibodies (bnAbs) in infection and to recreate those events by vaccination. Here, we report host tolerance mechanisms that limit the development of CD4-binding site (CD4bs), HCDR3-binder bnAbs via sequential HIV-1 Env vaccination. Vaccine-induced macaque CD4bs antibodies neutralize 7% of HIV-1 strains, recognize open Env trimers, and accumulate relatively modest somatic mutations. In naive CD4bs, unmutated common ancestor knock-in mice Env+B cell clones develop anergy and partial deletion at the transitional to mature B cell stage, but become Env− upon receptor editing. In comparison with repetitive Env immunizations, sequential Env administration rescue anergic Env+ (non-edited) precursor B cells. Thus, stepwise immunization initiates CD4bs-bnAb responses, but immune tolerance mechanisms restrict their development, suggesting that sequential immunogen-based vaccine regimens will likely need to incorporate strategies to expand bnAb precursor pools