Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer-4

<p><b>Copyright information:</b></p><p>Taken from "Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer"</p><p>http://www.biomedcentral.com/1471-2407/7/121</p><p>BMC Cancer 2007;7():121-121.</p><p>Published online 3 Jul 2007</p><p>PMCID:PMC1948004.</p><p></p>aCa-2, AsPc-1 and Capan-2 cells. The individual doses of gemcitabine and troxacitabine to achieve 90% (straight line) growth inhibition (Fa = 0.90), 75% (hyphenated line) growth inhibition (Fa = 0.75), and 50% (dotted line) growth inhibition (Fa = 0.50) were plotted on the x- and y-axes. Combination index (CI) values calculated using Calcusyn software is represented by points above (indicate antagonism between drugs) or below the lines (indicate synergy). (X symbol) ED(plus sign) EDand (open dotted circle ) ED

Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer-1

<p><b>Copyright information:</b></p><p>Taken from "Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer"</p><p>http://www.biomedcentral.com/1471-2407/7/121</p><p>BMC Cancer 2007;7():121-121.</p><p>Published online 3 Jul 2007</p><p>PMCID:PMC1948004.</p><p></p>aCa-2, AsPc-1 and Capan-2 cells. The individual doses of gemcitabine and troxacitabine to achieve 90% (straight line) growth inhibition (Fa = 0.90), 75% (hyphenated line) growth inhibition (Fa = 0.75), and 50% (dotted line) growth inhibition (Fa = 0.50) were plotted on the x- and y-axes. Combination index (CI) values calculated using Calcusyn software is represented by points above (indicate antagonism between drugs) or below the lines (indicate synergy). (X symbol) ED(plus sign) EDand (open dotted circle ) ED

Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer-3

<p><b>Copyright information:</b></p><p>Taken from "Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer"</p><p>http://www.biomedcentral.com/1471-2407/7/121</p><p>BMC Cancer 2007;7():121-121.</p><p>Published online 3 Jul 2007</p><p>PMCID:PMC1948004.</p><p></p>xacitabine or gemcitabine either alone or in combination at a ratio of 1:100 of gemcitabine vs. troxacitabine, for 72 h, after which cells were harvested by trypsinization and their numbers determined using electronic particle counting. Each data point represents the mean ± SD of three determinations. Gemcitabine (open squares), troxacitabine (open inverted triangle), gemcitabine + troxacitabine (open circle). The GIvalues for exposures to troxacitabine and gemcitabine alone are given in Table 2

Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer-0

<p><b>Copyright information:</b></p><p>Taken from "Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer"</p><p>http://www.biomedcentral.com/1471-2407/7/121</p><p>BMC Cancer 2007;7():121-121.</p><p>Published online 3 Jul 2007</p><p>PMCID:PMC1948004.</p><p></p>xacitabine or gemcitabine either alone or in combination at a ratio of 1:100 of gemcitabine vs. troxacitabine, for 72 h, after which cells were harvested by trypsinization and their numbers determined using electronic particle counting. Each data point represents the mean ± SD of three determinations. Gemcitabine (open squares), troxacitabine (open inverted triangle), gemcitabine + troxacitabine (open circle). The GIvalues for exposures to troxacitabine and gemcitabine alone are given in Table 2