New early Triassic Lingulidae (Brachiopoda) genera and species from South China

Two new genera, Sinolingularia gen. nov. and Sinoglottidia gen. nov., together with three new species, Sinolingularia huananensis gen. et sp. nov., Sinolingularia yini gen. et sp. nov. and Sinoglottidia archboldi gen. et sp. nov., are described on the basis of a large collection of well-preserved specimens from several sections straddling the Permian - Triassic boundary in South China. <br /

Quinoxaline chemistry. Part 11. 3-phenyl-2[phenoxy- and phenoxymethyl]-6(7) or 6,8-substituted quinoxalines and N-[4-(6(7)-substituted or 6,8-disubstituted-3-phenylquinoxalin-2-yl)hydroxy or hydroxymethyl]benzoylglutamates. Synthesis and evaluation of in

Twenty-four out of twenty-nine quinoxalines were selected at the National Cancer Institute, Bethesda, Md, USA, for in vitro anticancer screening. Among these, 10 derivatives exhibited high values of percent tumor growth inhibition at a concentration of 10(-4) M in all cancer cell lines. Four of these compounds maintained these values at 10(-5) M, whereas a certain number exhibited significant values of percent inhibition at the most diluted concentrations (10(-8)-10(-6) M). Inhibitory activity against dihydrofolate reductase (DHFR) (bovine and rat liver) was determined for the most active compounds. This test showed that this type of quinoxaline exhibited an appreciable activity in comparison with the previously described aza analogues. In the other test (Lactobacillus casei, thymidylate synthase (TS), human HTS) no or poor activity was detected in both series of compounds. (C) 1998 Elsevier Science S.A. All rights reserved

WEALTHY, A Wearable Health-Care System: New frontier on E-Textile

A comfortable health monitoring system named WEALTHY is presented. The system is based on a wearable interface implemented by integrating fabric sensors, advanced signal processing techniques and modern telecommunication systems, on a textile platform. Conducting and piezoresistive materials in form of fibre and yarn are integrated in a gar- ment and used as sensors, connectors and electrode elements. Simultaneous recording of vital signs allows extrapolation of more complex parameters and inter-signal elaboration that contribute to produce alert messages and patient table. The purpose of this publication is to evaluate the performance of the textile platform and the possibility of the simultane- ous acquisition of several biomedical signals

WEALTHY - a wearable healthcare system: new frontier on e-textile

A comfortable health monitoring system named WEALTHY is presented. The system is based on a wearable interface implemented by integrating fabric sensors, advanced signal processing techniques and modern telecommunication systems, on a textile platform. Conducting and piezoresistive materials in form of fibre and yarn are integrated in a garment and used as sensors, connectors and electrode elements. Simultaneous recording of vital signs allows extrapolation of more complex parameters and inter-signal elaboration that contribute to produce alert messages and patient table. The purpose of this publication is to evaluate the performance of the textile platform and the possibility of the simultaneous acquisition of several biomedical signals

Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities

Several diamino quinoxalines were designed, synthesized and evaluated as anti-tumor agents. Two compounds showed the most potent cytotoxic activities against the leukemia CCRF-CEM cell line (GI50 < 0.01 μM) and the ovarian cancer cell line OVCAR-4 (GI50 = 0.03 μM), respectively, with comparable/better activities than Methotrexate (MTX). Docking calculations of the complexes of hDHFR with the most active compounds identified the binding mode of the described molecules with respect to MTX