2 research outputs found
Endoscopic diverticulectomy with platelet-rich plasma of intraluminal duodenal diverticulum
Background: Procedure-related bleeding remains a common complication after endoscopic diverticulectomy of intraluminal duodenal diverticulum (IDD). The optimal endoscopic approach to IDD has not been established. Platelet-rich plasma (PRP) has proven
biological properties to reduce risk of bleeding.
Materials and Methods: The authors describe a novel technique in which endoscopic diverticulectomy was performed with prior
submucosal injection of PRP (IRB approval PT-16-002).
Case Report: A 62-year-old woman with a large IDD like a âwindsockâ underwent endoscopic diverticulectomy with PRP obtained
from a sample of patientâs blood. IDD was resected with EMR technique using a standard polypectomy snare. No immediate or delayed bleeding was noted. Follow-up endoscopy 3 months later revealed complete mucosal healing and open communication to the
distal duodenum.
Conclusion: Endoscopic diverticulectomy with PRP is an option in patients with IDDMedicin
Local injection of anti-cancer drugs in an experimental model of colorectal cancer
Purpose: Endoscopic resection of colorectal lesions significantly decreases the risk of colorectal cancer (CRC) incidence and death.
Patients with invasive neoplasia or metastatic CRC have an evident poorer prognosis. Next step could be a more personalized treatment strategy, as a targeted therapy by direct injection of active substances in a selected lesion. The aim was to evaluate the efficacy
of intratumoral injection of a drug-eluting platform (CoverGel) with different anti-cancer drugs in a rat model of azoxymethane
(AOM)-induced CRC.
Methods: Experimental CRC was induced in 20 rats. Animals were randomized in five groups (four each): CoverGel + Aflibercept
(AFL), CoverGel + Bevacizumab (BVZ), CoverGel + Cetuximab (CTX), CoverGel + Panitumumab (PNT) and CoverGel + Irinotecan
(IRT). Endoscopic, histological and necrosis score (0-3 scale) test were performed during follow-up to evaluate clinical success.
Results: All animals developed invasive neoplasia (NICE 3, JNET 3), 7.2 mm as mean size (range 6 - 8). Intratumoral injection was
feasible in all animals with no adverse events. AFL, an angiogenesis inhibitor agent, in comparison with the other medications (BVZ,
CTX, PNT and IRT) obtained the best results: significantly reduction in tumor size (-30% vs. -10%, -3%, +2% and + 2%; p < 0.05,
respectively) and significantly higher necrosis score (3 vs. 1, 0.3, 0 and 0; p < 0.05, respectively).
Conclusion: Angiogenesis inhibitors medications produced the higher cell necrosis and reduction in tumor size in an experimental
model of CRC. Intratumoral injection of a drug-eluting platform could open a new way to manage invasive CRC.Medicin