Preterm and term preeclampsia in the second pregnancy according to gestational age in the first birth, 1998–2012.

<p>609962 women with spontaneous first deliveries. (<i>n</i> = 609962).</p

Preterm and term preeclampsia in the second pregnancy according to gestational age and PROM in the first birth, 1998–2012.

<p>(<i>n</i> = 153009).</p

Preelampsia in the second pregnancy according to gestational age at the first birth in the same woman without preeclampsia in the first pregnancy.

<p>Norway 1967–2012.</p

Background characteristics of women who had two successive singleton infants without preeclampsia in the first pregnancy and numbers and proportions in the second pregnancy of preterm preeclampsia (<37 weeks of gestation), term preeclampsia and no preeclampsia, Norway1967 to 2012.

<p>(<i>n</i> = 712511).</p

Associations between perinatal death and an interaction term of zBW and observed or hypothetical maternal diabetes: 958 172 infants with higher than mean zBW, Norway 1967–2011.

<p>Associations between perinatal death and an interaction term of zBW and observed or hypothetical maternal diabetes: 958 172 infants with higher than mean zBW, Norway 1967–2011.</p

Characteristics of four models applied in the analyses.

<p>Characteristics of four models applied in the analyses.</p

Associations between perinatal death and zBW in selected population subsets.

<p>BMI: Body Mass Index; CI: confidence interval; OR: odds ratio; zBW: z-score birth weight, standardized for year of birth, sex, birth order, gestational week, and plurality. (A) Births 1967–1998, analysis in a model including potential confounders in Model 2 (B) Births 1999–2011, analysis in a model including maternal smoking and birth/placenta weight ratio in addition to potential confounders in Model 2 (C) Births 2006–2011, analysis in a 40% sample of births, in a model including maternal prepregnancy BMI in addition to potential confounders in Model 2. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172891#pone.0172891.t001" target="_blank">Table 1</a> foot-note for details.</p

Associations between perinatal death and zBW in 3 different analytic models.

<p>CI: confidence interval; OR: odds ratio; zBW: z-score birth weight, standardized for year of birth, sex, birth order, gestational week, and plurality. (A) Model 1, crude (B) Model 2, includes potential family and individual level confounders (C) Model 4, fixed-effects model including 23 546 participants in 7686 families, discordant with respect to perinatal death. Model details provided in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172891#pone.0172891.t001" target="_blank">Table 1</a>.</p

Population fraction of perinatal deaths attributed to deviance from mean sibling birth weight, according to zBW category and selected population subsets: Norway 1967–2011.

<p>Population fraction of perinatal deaths attributed to deviance from mean sibling birth weight, according to zBW category and selected population subsets: Norway 1967–2011.</p

Distribution of independent variables and their relations to birth weight and perinatal mortality: 1 925 929 infants born in Norway 1967–2011.

<p>Distribution of independent variables and their relations to birth weight and perinatal mortality: 1 925 929 infants born in Norway 1967–2011.</p