Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study

The aim of this study was to evidence the clinical efficacy of an alcohol-free mouthwash containing 5.0% (W/V) Brazilian green propolis (MGP 5%) for the control of plaque and gingivitis. Twenty five subjects, men and women aging between 18 and 60 years old (35 ± 9), were included in a clinical trials phase II study who had a minimum of 20 sound natural teeth, a mean plaque index of at least 1.5 (PI), and a mean gingival index of at least 1.0 (GI). They were instructed to rinse with 10 mL of mouthwash test for 1 minute, immediately after brushing in the morning and at night. After 45 and 90 days using mouthwash, the results showed a significant reduction in plaque and in gingival index when compared to samples obtained in baseline. These reductions were at 24% and 40%, respectively (P < .5). There were no important side effects in soft and hard tissues of the mouth. In this study, the MGP 5% showed evidence of its efficacy in reducing PI and GI. However, it is necessary to perform a clinical trial, double-blind, randomized to validate such effectiveness

Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study

The aim of this study was to evidence the clinical efficacy of an alcohol-free mouthwash containing 5.0% (W/V) Brazilian green propolis (MGP 5%) for the control of plaque and gingivitis. Twenty five subjects, men and women aging between 18 and 60 years old (35 ± 9), were included in a clinical trials phase II study who had a minimum of 20 sound natural teeth, a mean plaque index of at least 1.5 (PI), and a mean gingival index of at least 1.0 (GI). They were instructed to rinse with 10 mL of mouthwash test for 1 minute, immediately after brushing in the morning and at night. After 45 and 90 days using mouthwash, the results showed a significant reduction in plaque and in gingival index when compared to samples obtained in baseline. These reductions were at 24% and 40%, respectively (P &lt; .5). There were no important side effects in soft and hard tissues of the mouth. In this study, the MGP 5% showed evidence of its efficacy in reducing PI and GI. However, it is necessary to perform a clinical trial, double-blind, randomized to validate such effectiveness

Estudo coorte prospectivo em terapia de manutenção periodontal: análise de parâmetros clínicos periodontais, progressão de periodontite, perda dentária e de modelo multifuncional para avaliação do risco periodontal

Exportado OPUSMade available in DSpace on 2019-08-14T08:37:39Z (GMT). No. of bitstreams: 1 tese_telma_artigos_1__2__3_e_4__2008_revisado.pdf: 2182186 bytes, checksum: 008afe3dd0ad822c686ca12051ba081b (MD5) Previous issue date: 23Este estudo de coorte aberto prospectivo teve como objetivo avaliar a progressão da periodontite, a influência de variáveis preditoras de risco e avaliar a incidência e motivos para a ocorrência de perda dentária (PD) em indivíduos inseridos num programa de terapia de manutenção periodontal (TMP) em ambiente universitário. Metodologia: 250 indivíduos com diagnóstico de periodontite crônica moderadaavançada, que finalizaram terapia periodontal ativa foram recrutados na Faculdade de Odontologia da Universidade Federal de Minas Gerais, Brasil. Todosforam submetidos a um exame clínico periodontal completo (TMP1) e a uma coleta de variáveis sociais, demográficas e biológicas de interesse. Avaliou-se o grau de cooperação destes indivíduos (cooperadores, cooperadores irregulares e não cooperadores) quanto à adesão ao programa de TMP em re-chamadas trimestrais (TMP2, TMP3 e TMP4) pelo período de 12 meses. Assim, 150 indivíduos considerados cooperadores completos (60%) foram elegíveis para esta pesquisa. Emtodas as re-chamadas foram coletados os seguintes dados: índice de placa (IP), sangramento a sondagem (SS), profundidade de sondagem (PS), níveis clínicos de inserção (NCI), supuração (S) e envolvimento de furca (EF), em todos dentes presentes (com exceção de terceiros molares). Identificou-se, pela plausibilidade biológica, quais variáveis preditoras de risco poderiam influenciar a condição clínica periodontal e a progressão da periodontite. O efeito de variáveis de interesse econfundimentofoi testado por análise univariada e regressão logística multivariada, assim como motivos e tipos de dentes perdidos. Resultados: Observou-se uma melhora considerável nos parâmetros clínicos periodontais na maioria dos indivíduos. Durante o período de monitoramento, 130 indivíduos (86,7%) tiveram estabilidade periodontal e 20 indivíduos (13,3%) apresentaram progressão de periodontite.Diabetes não foi associada à progressão de periodontite (p=0,67) e o tabagismo foi significantemente associado a maior progressão de periodontite (RC=2,7; 95% IC: 1,01-7,22). 28 indivíduos (18,66%) apresentaram perda dentária os quais somaram 47 dentes perdidos (1,4%). Os motivos e números de dentes perdidos foram respectivamente: doença periodontal (n=34; 72,3%), cárie (n=3; 6,4%), motivos protéticos (n=9; 19,2%), perfuração radicular (n=1; 2,1%). Molares apresentaram maior mortalidade dental do que não molares e homens 3 vezes mais chances de PD do que mulheres (RC=3,16; 95% IC: 1,28-7,78). Indivíduos com 10% de sítios com PS entre 4 e 6 mm apresentaram 5 vezes mais chances de PD (RC= 5,13; IC 95%: 2,04-12,09). A determinação do risco individual pelo modelo ARP (Avaliação do Risco Periodontal) resultou na classificação dos indivíduos em 02(1,3%) de baixo risco, 83 (55,3%) de moderado risco e 65 (43,4%) de alto risco àrecorrência de periodontite. Conclusões:Os programas de manutenção periodontalem ambiente universitário podem estabilizar a condição periodontal obtida apósterapia ativa e, adicionalmente, controlar e/ou minimizar a ação de variáveispreditoras de risco a progressão da periodontite. Neste estudo, a incidência de PDfoi pequena e restrita a poucos indivíduos. A adoção do modelo ARP contribui para adeterminação do risco individual dos indivíduos,permitindo que os escores de riscosejam comparados ao longo do tempo. Assim, este instrumento pode ser válido paramonitorar particularmente variáveis mutáveis de risco e auxiliar na estratégia,determinação e cooperação nos programas de TMP. Aestabilidade dos tecidosperiodontais, controle de variáveis de risco e redução da PD podem ser metasalcançáveis pelos programas de TMP, refletindo a sua eficiência e propiciandomelhor qualidade de vida para indivíduos periodontalmente susceptíveis.This open prospective cohort study aimed to evaluate the progression of periodontitisand, in addition, the incidence, the reasons and the role of risk predictors on theoccurrence of tooth loss (TL) in individuals inserted in a program of periodontalmaintenance therapy (PMT) in academic environment. Methods: 250 individualsdiagnosed with moderate/advanced chronic periodontitis, that had finishedactiveperiodontal therapy, in the Faculty of Dentistry of the Federal University of MinasGerais, Brazil, were selected. Individuals were submitted to a complete clinicalperiodontal examination (PMT1) and collection of social, demographic and biologicalvariables of interest was performed. The degree of compliance of these individuals,(compliers, irregular compliers and non compliers) according to the adhesion to theTMP program in quarterly recalls (PMT2, PMT3 and PMT4), wasevaluated during 12months period. A total of 150 individuals, that were considered complete compliers(60%), became eligible for this study. In the recall visits, the following data werecollected for all teeth (with exception of third molars): plaque index (PI), bleeding onprobing (BOP), probing depth (PD), clinical attachment level (CAL), suppuration (SU)and furcation involvement (FI). It was identified, according to the biologicalplausibility, which risk predictors could influence the periodontal clinical condition andthe progression of the periodontitis. The effect of variables of interest andconfounding was tested by univariate analysis and multivaried logistic regression, aswell as the reasons and types of teeth that were lost. Results: A considerableimprovement in periodontal clinical parameters was observed in the majority of theindividuals. During the monitoring, 130 individuals (86.7%) showed periodontalstability and 20 individuals (13.3%) presented periodontitis progression. Diabeteswas not associated with periodontitis progression (p=0.67) and, in contrast, smokingwas significantly associated with periodontitis progression (OR=2.7; 95% IC 1.01-7.22). 28 individuals (18.66%) presented TL, resulting in a total of 47 lost teeth(1.4%). The reasons and numbers of tooth loss and numbers were, respectively:periodontal disease (n=34; 72.3%), caries (n=3; 6.4%), prosthetic reasons (n=9;19.2%), root perforation (n=1; 2.1%). Molars presented greater tooth mortality thannon molars and men presented 3 times more odds of TL than women (OR=3.16;95% IC: 1.28-7.78). Additionally, individuals with 10% of sites with PD between 4 and6mm presented 5 times more odds of TL (OR= 5.13; IC 95%: 2.04 12.09). Theperiodontal risk assessment (PRA) resulted in the classification of individuals in 02(1.3%) low risk, 83 (55.3%) moderate risk and 65 (43.4%) of high-risk for recurrenceof periodontitis. Conclusions: The programmes of periodontal maintenance inacademic environment can stabilize the periodontal condition obtained after activetherapy, additionally to control and/or minimize the action of risk predictors on theprogression of periodontitis. In this study, the TL incidence was small and restrictedto few individuals. The adoption of the model PRA contributes to the determination ofrisk of individuals allowing the risk scores are compared over time. So, thisinstrument can be particularly monitoring changeable risk predictors and assisting inthe strategy, determination and compliance in the PMT programs. The stability ofperiodontal sites, the control of risk predictors and the reduction of TL can bepredictable goals for the PMT programs, reflecting its effectiveness and betterimproving quality of life for individuals susceptible to periodontitis

Prospective study of complier individuals under periodontal maintenance therapy: analysis of clinical periodontal parameters, risk predictors and the progression of periodontitis

Made available in DSpace on 2019-09-12T16:56:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2009Fundação de Amparo à Pesquisa do Estado de Minas Gerais (Fapemig)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Lorentz TCM, Cota LOM, Cortelli JR, Vargas AMD, Costa FO. Prospective study of complier individuals under periodontal maintenance therapy: analysis of clinical periodontal parameters, risk predictors and the progression of periodontitis. J Clin Periodontol 2009; 36: 58-67. doi: 10.1111/j.1600-051X.2008.01342.x. This prospective study aimed to evaluate the progression of periodontitis and the influence of risk variables among individuals attending a programme of periodontal maintenance treatment in an academic environment. A total of 150 individuals diagnosed with chronic moderate-advanced periodontitis, and who had finished active periodontal treatment, were incorporated into the periodontal maintenance therapy. Social, demographic and biological variables of interest from subjects were collected at quarterly recalls, over a 12-month period. The effect of variables of interest and confounding on the periodontal status and progression of periodontitis was tested by univariate and multivariate logistic analysis. A total of 130 subjects (86.7%) showed stable periodontal status, whereas 20 subjects (13.3%) presented periodontitis progression. Twenty-eight subjects (18.66%) presented tooth loss that resulted in a total of 47 lost teeth (1.38%). Diabetes was not found to be associated with periodontitis progression (p=0.67). Smoking was significantly associated with a greater progression of periodontitis (OR=2.7, 95% CI 1.01-7.22). Periodontal maintenance programmes in academic environment can stabilize the periodontal condition obtained after active periodontal therapy as well as control the action of risk variables for the progression of periodontitis.[Medeiros Lorentz, Telma Campos; Miranda Cota, Luis Otavio; Duarte Vargas, Andrea Maria; Costa, Fernando Oliveira] Univ Fed Minas Gerais, Dept Periodontol, Sch Dent, BR-31270901 Belo Horizonte, MG, Brazil[Cortelli, Jose Roberto] Universidade de Taubaté (Unitau), Dept Dent, Periodont Res Div, Sao Paulo, Brazi

Tooth loss in individuals under periodontal maintenance therapy: prospective study

Made available in DSpace on 2019-09-12T16:26:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2010This prospective study aimed to evaluate the incidence, the underlying reasons, and the influence of predictors of risk for the occurrence of tooth loss (TL) in a program of Periodontal Maintenance Therapy (PMT). The sample was composed of 150 complier individuals diagnosed with chronic moderate-severe periodontitis who had finished active periodontal treatment and were incorporated in a program of PMT. Social, demographic, behavioral and biological variables were collected at quarterly recalls, over a 12-month period. The effect of predictors of risk of and confounding for the dependent variable TL was tested by univariate and multivariate analysis, as well as the underlying reasons and the types of teeth lost. During the monitoring period, there was a considerable improvement in periodontal clinical parameters, with a stability of periodontal status in the majority of individuals. Twenty-eight subjects (18.66%) had TL, totaling 47 lost teeth (1.4%). The underlying reasons for TL were: periodontal disease (n = 34, 72.3%), caries (n = 3, 6.4%), prosthetic reasons (n = 9, 19.2%), and endodontic reasons (n = 1, 2.1%). Additionally, subjects with 10% of sites with probing depth between 4 and 6 mm were 5 times more likely to present TL (OR = 5.13, 95% CI 2.04-12.09). In this study, the incidence of TL was small and limited to few individuals. Additionally, gender and severity of periodontitis were significantly associated with TL during the monitoring period.[Cortelli, José Roberto] Universidade de Taubaté, BrazilVargas, Andréia Maria Duarte] Universidade Federal de Minas Gerais, BrazilLorentz, Telma Campos Medeiros; Cota, Luís Otávio Miranda; Costa, Fernando Oliveira] Universidade Federal de Minas Gerais, Brazi

Prospective Study in Periodontal Maintenance Therapy: Comparative Analysis Between Academic and Private Practices

Made available in DSpace on 2019-09-12T16:56:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2012Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Background: This prospective study aims to evaluate and compare the periodontal status, periodontitis progression, tooth loss, and influence of predictable risk variables of two periodontal maintenance therapy programs over a 12-month period. Methods: A total of 288 individuals diagnosed with chronic moderate-to-advanced periodontitis, who had finished active periodontal treatment, were evaluated in a public academic environment (AG) (n = 138), as well as in a private clinic (PG) (n = 150). A full-mouth periodontal examination was performed at baseline and at quadrimestral recalls, evaluating plaque index, probing depth, clinical attachment level, furcation involvement, bleeding on probing (BOP), and suppuration. Individuals' social, demographic, and biologic data, as well as compliance with recalls, were recorded. The effect of variables of interest and confounders were tested by univariate and multivariate analysis. Results: The PG demonstrated lower rates of periodontitis progression and tooth loss than did the AG. After adjusting for confounders, the risk variables of BOP (P=0.047), smoking (P = 0.003), and diabetes (P = 0.028) for the PG and smoking (P=0.047) for the AG showed a negative influence on periodontal status. Conclusions: In both groups, the periodontal maintenance therapy minimized the negative effect of the risk variables. However, PG showed significantly less progression of periodontitis and tooth loss compared to AG. J Periodontol 2012;83:301-311.[Costa, Fernando Oliveira; Santuchi, Camila Carvalho; Pereira Lages, Eugenio Jose; Miranda Cota, Luis Otavio; Medeiros Lorentz, Telma Campos; Costa, Jose Eustaquio] Univ Fed Minas Gerais, Dept Periodontol, Sch Dent, BR-31270901 Belo Horizonte, MG, Brazil[Cortelli, Sheila Cavalca; Cortelli, Jose Roberto] Universidade de Taubaté (Unitau), Dept Dent, Periodont Res Div, Sao Paulo, Brazi

Oral Impact on Daily Performance, Personality Traits, and Compliance in Periodontal Maintenance Therapy

Made available in DSpace on 2019-09-12T16:56:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2011Fundação de Amparo a Pesquisa do Estado de Minas Gerais (Fapemig) (FAPEMIG-Brazil) [10137]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Background: To our knowledge, the association between personality traits and oral health impacts on daily activities among patients under periodontal maintenance was not previously evaluated. The present study aims to determine the oral health impacts among regular- and erratic-complier patients and their correlations with personality traits by means of the oral impacts on daily performance (OIDP) and the neuroticism extraversion openness five-factor inventory (NEO FFI-R) instruments. Methods: A total of 58 regular and 58 erratic compliers matched by sex, diabetes, and smoking were recruited from a cohort of 238 participants under periodontal maintenance. Periodontal examinations and questionnaire applications were performed in recalls during a 3-year interval. The influence of variables of interest on the OIDP was evaluated through univariate and multivariate linear regression analyses. Results: The periodontal status of regular compliers was significantly better than that of erratic compliers. Erratic compliers presented higher OIDP scores (36.34 +/- 6.64) compared to regular compliers (30.45 +/- 7.72). Higher scores of neuroticism and conscientiousness (R(2) = 68%; P <0.001) were associated with higher OIDP scores among regular compliers, whereas among erratic compliers, lower scores of neuroticism, higher openness, and extraversion (R(2) = 77%; P = 0.001) were associated with higher OIDP scores. Conclusion: Personality traits, mainly neuroticism, showed significant influences on OIDP among patients under periodontal maintenance. J Periodontol 2011;82:1146-1154.[Costa, Fernando Oliveira; Miranda Cota, Luis Otavio; Pereira Lages, Eugenio Jose; Costa, Jose Eustaquio; Medeiros Lorentz, Telma Campos] Univ Fed Minas Gerais, Dept Periodontol, Sch Dent, BR-31270901 Belo Horizonte, MG, Brazil[Vilela Camara, Gislene Clemente] Pontifical Univ Catholic Minas Gerais, Inst Psychol, Belo Horizonte, MG, Brazil[Cortelli, Sheila Cavalca; Cortelli, Jose Roberto] Universidade de Taubaté (Unitau), Periodont Res Div, Dept Den

Periodontal Risk Assessment Model in a Sample of Regular and Irregular Compliers Under Maintenance Therapy: A 3-Year Prospective Study

Made available in DSpace on 2019-09-12T16:56:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2012Fundação de Amparo à Pesquisa do Estado de Minas Gerais (Fapemig)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Background: The purpose of this study is to investigate the association of the periodontal risk assessment (PRA) model with the recurrence of periodontitis and tooth loss during periodontal maintenance therapy (PMT). Methods: In a prospective PMT program, 75 regular complier (RC) and 89 erratic complier (EC) patients were selected. A periodontal examination and PRA were performed after active periodontal therapy and after 3 years of PMT. Risk profiles (low, moderate, or high) of participants were evaluated, and the recurrence of periodontitis and tooth loss were analyzed using univariate and multivariate analyses. Results: RCs showed less recurrence of periodontitis and tooth loss than ECs (P<0.05). Rates of periodontitis recurrence in RCs and ECs were 2.7% and 3.4%, respectively, for the moderate-risk profile and 6.7% and 11.2%, respectively, for the high-risk profile. During PMT, 49 teeth (0.65 +/- 1.4 teeth per participant) were lost in the RC group, and 70 teeth (0.78 +/- 2.1 teeth per participant) were lost in the EC group. High-risk profile participants showed more recurrence of periodontitis and lost significantly more teeth than did participants with moderate- or low-risk profiles in RC and EC groups (P<0.05). Conclusion: The risk profile influenced the recurrence of periodontitis and tooth loss. RCs had less recurrence of periodontitis and less tooth loss. The PRA model can be useful in particularizing the risk of patients and adjusting recall intervals. J Periodontol 2012;83:292-300.[Costa, Fernando Oliveira; Miranda Cota, Luis Otavio; Pereira Lages, Eugenio Jose; Lima Oliveira, Ana Paula; Medeiros Lorentz, Telma Campos; Costa, Jose Eustaquio] Univ Fed Minas Gerais, Dept Periodontol, Sch Dent, BR-31270901 Belo Horizonte, MG, Brazil[Cortelli, Sheila Cavalca; Cortelli, Jose Roberto] Universidade de Taubaté (Unitau), Periodont Res Div, Dept Den